Discovery of novel chrysin derivatives as potential Anti-Psoriasis agents

[Display omitted] •Twenty novel chrysin derivatives 4a-4 t were designed and synthesized.•The anti-inflammatory activity of compounds 4a-4 t was evaluated in RAW264.7 cells, and compounds 4 h, 4 k, and 4o had higher inflammatory activities and lower toxicity than chrysin.•Compound 4o inhibited the l...

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Veröffentlicht in:	Bioorganic chemistry 2024-09, Vol.150, p.107599, Article 107599
Hauptverfasser:	Zhao, Xiujuan, Du, Chenghong, Zeng, Yongcheng, Chen, Yanmei, Xu, Jiacai, Yin, Xunqing, Hu, Chunyan, Mao, Zewei, Lin, Yuping
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory activity Anti-psoriasis Chrysin derivatives Mechanism
Online-Zugang:	Volltext
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