Surgery for Infrarenal Retroperitoneal Node Metastases from Colon Cancer
Purpose Treatment of retroperitoneal lymph node metastases (RPN) from colon cancer (CC) is a therapeutic challenge. Available evidence supporting a curative approach is weak and uncertainties remain concerning the extent of the dissection, the optimal timing for surgery, and the role of adjuvant rad...
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| Veröffentlicht in: | Journal of gastrointestinal cancer 2024-09, Vol.55 (3), p.1306-1312 |
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| container_title | Journal of gastrointestinal cancer |
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| creator | Dulac, Anne-Sophie Genova, Pietro Benoit, Olivier Neuzillet, Cindy Hajjam, Mostapha El Emile, Jean-François Peschaud, Frédérique Lupinacci, Renato Micelli |
| description | Purpose
Treatment of retroperitoneal lymph node metastases (RPN) from colon cancer (CC) is a therapeutic challenge. Available evidence supporting a curative approach is weak and uncertainties remain concerning the extent of the dissection, the optimal timing for surgery, and the role of adjuvant radiotherapy. We report the outcomes of a curative intent strategy in a recent monocentric series of patients.
Methods
We did a retrospective review of all curative intent surgical treatment of RPN from CC performed consecutively in a French university hospital from June 2015 to April 2021. Demographics, clinicopathological, and molecular characteristics were evaluated. We describe recurrence-free and overall survival and factors related to recurrence.
Results
Records from 18 patients were reviewed. The median age was 69 years. Most of the patients were male (55%), ASA 1–2 (94%), had a left-sided primary colon cancer (73%), and had metachronous RPN (62%). Thirteen patients (72%) experienced recurrence. Recurrence was often limited to RPN (27%) or liver (22%). Four patients underwent a second surgery for RPN recurrence. Median disease-free and overall survival were 22 months and 50 months after RPN surgery. We did not find any factor associated with recurrence. Short-term recurrence ( |
| doi_str_mv | 10.1007/s12029-024-01086-8 |
| format | Article |
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Treatment of retroperitoneal lymph node metastases (RPN) from colon cancer (CC) is a therapeutic challenge. Available evidence supporting a curative approach is weak and uncertainties remain concerning the extent of the dissection, the optimal timing for surgery, and the role of adjuvant radiotherapy. We report the outcomes of a curative intent strategy in a recent monocentric series of patients.
Methods
We did a retrospective review of all curative intent surgical treatment of RPN from CC performed consecutively in a French university hospital from June 2015 to April 2021. Demographics, clinicopathological, and molecular characteristics were evaluated. We describe recurrence-free and overall survival and factors related to recurrence.
Results
Records from 18 patients were reviewed. The median age was 69 years. Most of the patients were male (55%), ASA 1–2 (94%), had a left-sided primary colon cancer (73%), and had metachronous RPN (62%). Thirteen patients (72%) experienced recurrence. Recurrence was often limited to RPN (27%) or liver (22%). Four patients underwent a second surgery for RPN recurrence. Median disease-free and overall survival were 22 months and 50 months after RPN surgery. We did not find any factor associated with recurrence. Short-term recurrence (< 6 months) was associated with shorter overall survival (0.031).
Conclusion
The current results suggest that RPN resection is feasible and associated with long survival in selected patients. Further studies evaluating the benefit of curative strategies including radical surgery for patients with potentially resectable RPN are warranted.</description><identifier>ISSN: 1941-6628</identifier><identifier>ISSN: 1941-6636</identifier><identifier>EISSN: 1941-6636</identifier><identifier>DOI: 10.1007/s12029-024-01086-8</identifier><identifier>PMID: 38954189</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cancer Research ; Gastroenterology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Oncology ; Radiotherapy</subject><ispartof>Journal of gastrointestinal cancer, 2024-09, Vol.55 (3), p.1306-1312</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-fa11f0473c238023f0f10371514d4a52067a63620920bc120ecfecd4366bf2723</cites><orcidid>0000-0003-2527-7949</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12029-024-01086-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12029-024-01086-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38954189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dulac, Anne-Sophie</creatorcontrib><creatorcontrib>Genova, Pietro</creatorcontrib><creatorcontrib>Benoit, Olivier</creatorcontrib><creatorcontrib>Neuzillet, Cindy</creatorcontrib><creatorcontrib>Hajjam, Mostapha El</creatorcontrib><creatorcontrib>Emile, Jean-François</creatorcontrib><creatorcontrib>Peschaud, Frédérique</creatorcontrib><creatorcontrib>Lupinacci, Renato Micelli</creatorcontrib><title>Surgery for Infrarenal Retroperitoneal Node Metastases from Colon Cancer</title><title>Journal of gastrointestinal cancer</title><addtitle>J Gastrointest Canc</addtitle><addtitle>J Gastrointest Cancer</addtitle><description>Purpose
Treatment of retroperitoneal lymph node metastases (RPN) from colon cancer (CC) is a therapeutic challenge. Available evidence supporting a curative approach is weak and uncertainties remain concerning the extent of the dissection, the optimal timing for surgery, and the role of adjuvant radiotherapy. We report the outcomes of a curative intent strategy in a recent monocentric series of patients.
Methods
We did a retrospective review of all curative intent surgical treatment of RPN from CC performed consecutively in a French university hospital from June 2015 to April 2021. Demographics, clinicopathological, and molecular characteristics were evaluated. We describe recurrence-free and overall survival and factors related to recurrence.
Results
Records from 18 patients were reviewed. The median age was 69 years. Most of the patients were male (55%), ASA 1–2 (94%), had a left-sided primary colon cancer (73%), and had metachronous RPN (62%). Thirteen patients (72%) experienced recurrence. Recurrence was often limited to RPN (27%) or liver (22%). Four patients underwent a second surgery for RPN recurrence. Median disease-free and overall survival were 22 months and 50 months after RPN surgery. We did not find any factor associated with recurrence. Short-term recurrence (< 6 months) was associated with shorter overall survival (0.031).
Conclusion
The current results suggest that RPN resection is feasible and associated with long survival in selected patients. Further studies evaluating the benefit of curative strategies including radical surgery for patients with potentially resectable RPN are warranted.</description><subject>Cancer Research</subject><subject>Gastroenterology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Radiotherapy</subject><issn>1941-6628</issn><issn>1941-6636</issn><issn>1941-6636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PwzAMhiMEYmPwBzigHrkUnI8m7RFVwCYNkPg4R1nroE1tM5L2sH9PoGNHJEu25dev7IeQSwo3FEDdBsqAFSkwkQKFXKb5EZnSQtBUSi6PDzXLJ-QshA2AFBmlp2TC8yITNC-mZP42-E_0u8Q6nyw6643HzjTJK_bebdGve9dh7J9djckT9ibEwJBY79qkdI3rktJ0FfpzcmJNE_Bin2fk4-H-vZyny5fHRXm3TCvG8j61hlILQvGK8RwYt2ApcEUzKmphMgZSmXg8g4LBqooPYmWxqgWXcmWZYnxGrkffrXdfA4Zet-tQYdOYDt0QNAeVccWBqShlo7TyLgSPVm_9ujV-pynoH4J6JKgjQf1LUOdx6WrvP6xarA8rf8iigI-CEEddZKc3bvCRWfjP9huVCnqC</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Dulac, Anne-Sophie</creator><creator>Genova, Pietro</creator><creator>Benoit, Olivier</creator><creator>Neuzillet, Cindy</creator><creator>Hajjam, Mostapha El</creator><creator>Emile, Jean-François</creator><creator>Peschaud, Frédérique</creator><creator>Lupinacci, Renato Micelli</creator><general>Springer US</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2527-7949</orcidid></search><sort><creationdate>20240901</creationdate><title>Surgery for Infrarenal Retroperitoneal Node Metastases from Colon Cancer</title><author>Dulac, Anne-Sophie ; Genova, Pietro ; Benoit, Olivier ; Neuzillet, Cindy ; Hajjam, Mostapha El ; Emile, Jean-François ; Peschaud, Frédérique ; Lupinacci, Renato Micelli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-fa11f0473c238023f0f10371514d4a52067a63620920bc120ecfecd4366bf2723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cancer Research</topic><topic>Gastroenterology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dulac, Anne-Sophie</creatorcontrib><creatorcontrib>Genova, Pietro</creatorcontrib><creatorcontrib>Benoit, Olivier</creatorcontrib><creatorcontrib>Neuzillet, Cindy</creatorcontrib><creatorcontrib>Hajjam, Mostapha El</creatorcontrib><creatorcontrib>Emile, Jean-François</creatorcontrib><creatorcontrib>Peschaud, Frédérique</creatorcontrib><creatorcontrib>Lupinacci, Renato Micelli</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dulac, Anne-Sophie</au><au>Genova, Pietro</au><au>Benoit, Olivier</au><au>Neuzillet, Cindy</au><au>Hajjam, Mostapha El</au><au>Emile, Jean-François</au><au>Peschaud, Frédérique</au><au>Lupinacci, Renato Micelli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surgery for Infrarenal Retroperitoneal Node Metastases from Colon Cancer</atitle><jtitle>Journal of gastrointestinal cancer</jtitle><stitle>J Gastrointest Canc</stitle><addtitle>J Gastrointest Cancer</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>55</volume><issue>3</issue><spage>1306</spage><epage>1312</epage><pages>1306-1312</pages><issn>1941-6628</issn><issn>1941-6636</issn><eissn>1941-6636</eissn><abstract>Purpose
Treatment of retroperitoneal lymph node metastases (RPN) from colon cancer (CC) is a therapeutic challenge. Available evidence supporting a curative approach is weak and uncertainties remain concerning the extent of the dissection, the optimal timing for surgery, and the role of adjuvant radiotherapy. We report the outcomes of a curative intent strategy in a recent monocentric series of patients.
Methods
We did a retrospective review of all curative intent surgical treatment of RPN from CC performed consecutively in a French university hospital from June 2015 to April 2021. Demographics, clinicopathological, and molecular characteristics were evaluated. We describe recurrence-free and overall survival and factors related to recurrence.
Results
Records from 18 patients were reviewed. The median age was 69 years. Most of the patients were male (55%), ASA 1–2 (94%), had a left-sided primary colon cancer (73%), and had metachronous RPN (62%). Thirteen patients (72%) experienced recurrence. Recurrence was often limited to RPN (27%) or liver (22%). Four patients underwent a second surgery for RPN recurrence. Median disease-free and overall survival were 22 months and 50 months after RPN surgery. We did not find any factor associated with recurrence. Short-term recurrence (< 6 months) was associated with shorter overall survival (0.031).
Conclusion
The current results suggest that RPN resection is feasible and associated with long survival in selected patients. Further studies evaluating the benefit of curative strategies including radical surgery for patients with potentially resectable RPN are warranted.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38954189</pmid><doi>10.1007/s12029-024-01086-8</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2527-7949</orcidid></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Cancer Research Gastroenterology Internal Medicine Medicine Medicine & Public Health Oncology Radiotherapy |
| title | Surgery for Infrarenal Retroperitoneal Node Metastases from Colon Cancer |
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