Enhancement of the Clastogenic Effects of Topotecan In Vivo by Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

Topotecan administered intraperitoneally at single doses of 0.25, 0.5, and 1 mg/kg induced chromosomal aberrations in bone marrow cells of F 1 (CBA×C57BL/6) hybrid mice in a dose-dependent manner. A tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor, an usnic acid derivative OL9-116 was inactive in a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2024-05, Vol.177 (1), p.30-34
Hauptverfasser:	Zhanataev, A. K., Kulakova, A. V., Luzina, O. A., Khomenko, T. M., Volcho, K. P., Salakhutdinov, N. F., Durnev, A. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Biomedical and Life Sciences Biomedicine Bone marrow Cell Biology Chromosome aberrations Chromosomes Cytogenetics DNA damage DNA repair Drug dosages Enzymes Experiments Internal Medicine Laboratory animals Laboratory Medicine Pathology Pharmacology Pharmacology and Toxicology Phosphodiesterase Research centers Topotecan Usnic acid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!