Patellar tendon biomechanical and morphologic properties and their relationship to serum clinical variables in persons with prediabetes and type 2 diabetes
Tendon biomechanical properties and fibril organization are altered in patients with diabetes compared to healthy individuals, yet few biomarkers have been associated with in vivo tendon properties. We investigated the relationships between in vivo imaging-based tendon properties, serum variables, a...
Gespeichert in:
| Veröffentlicht in: | Journal of orthopaedic research 2024-08, Vol.42 (8), p.1653-1669 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1669 |
|---|---|
| container_issue | 8 |
| container_start_page | 1653 |
| container_title | Journal of orthopaedic research |
| container_volume | 42 |
| creator | Patel, Shivam H Campbell, Nathan W C Emenim, Chinonso E Farino, Dominick O Damen, Frederick W Rispoli, Joseph V Goergen, Craig J Haus, Jacob M Sabbaghi, Arman Carroll, Chad C |
| description | Tendon biomechanical properties and fibril organization are altered in patients with diabetes compared to healthy individuals, yet few biomarkers have been associated with in vivo tendon properties. We investigated the relationships between in vivo imaging-based tendon properties, serum variables, and patient characteristics across healthy controls (n = 14, age: 45 ± 5 years, body mass index [BMI]: 24 ± 1, hemoglobin A1c [HbA1c]: 5.3 ± 0.1%), prediabetes (n = 14, age: 54 ± 5 years, BMI: 29 ± 2; HbA1c: 5.7 ± 0.1), and type 2 diabetes (n = 13, age: 55 ± 3 years, BMI: 33 ± 2, HbA1c: 6.7 ± 0.3). We used ultrasound speckle-tracking and measurements from magnetic resonance imaging (MRI) to estimate the patellar tendon in vivo tangent modulus. Analysis of plasma c-peptide, interleukin-1β (IL-1β), IL-6, IL-8, tumor necrosis factor-α (TNF-α), adiponectin, leptin, insulin-like growth factor 1 (IGF-1), and C-reactive protein (CRP) was completed. We built regression models incorporating statistically significant covariates and indicators for the clinically defined groups. We found that tendon cross-sectional area normalized to body weight (BWN CSA) and modulus were lower in patients with type 2 diabetes than in healthy controls (p |
| doi_str_mv | 10.1002/jor.25816 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3075363060</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3075363060</sourcerecordid><originalsourceid>FETCH-LOGICAL-c280t-47c08c37da84a80b5b51662928d57f37eefd50754ae9afe49b9c3849dd9d34513</originalsourceid><addsrcrecordid>eNo9kUtLxDAUhYMoOj4W_gHJUhcdb5Omj6UMvmBAFwruSprc2kjb1CSj-Fv8s8YZx9WFe8_54J5DyGkK8xSAXb5ZN2eiTPMdMkuFyBLBipddMoOC5wmwPD8gh96_AUCRsnKfHPAyAxACZuT7UQbse-lowFHbkTbGDqg6ORoleypHTQfrps729tUoOjk7oQsG_foUOjSOOuxlMHb0nZlosNSjWw1U9WbD-JDOyKaPFjPS6PZRST9N6CINdTxh2OK-JqSMbnfHZK-VvceTv3lEnm-unxZ3yfLh9n5xtUwUKyEkWaGgVLzQssxkCY1oRJrnrGKlFkXLC8RWCyhEJrGSLWZVU6kYQKV1pXkmUn5Ezjfc-N37Cn2oB-PVbyoj2pWveTTznEMOUXqxkSpnvXfY1pMzg3RfdQr1bxd17KJedxG1Z3_YVTOg_lduw-c_tXOIYQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3075363060</pqid></control><display><type>article</type><title>Patellar tendon biomechanical and morphologic properties and their relationship to serum clinical variables in persons with prediabetes and type 2 diabetes</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Patel, Shivam H ; Campbell, Nathan W C ; Emenim, Chinonso E ; Farino, Dominick O ; Damen, Frederick W ; Rispoli, Joseph V ; Goergen, Craig J ; Haus, Jacob M ; Sabbaghi, Arman ; Carroll, Chad C</creator><creatorcontrib>Patel, Shivam H ; Campbell, Nathan W C ; Emenim, Chinonso E ; Farino, Dominick O ; Damen, Frederick W ; Rispoli, Joseph V ; Goergen, Craig J ; Haus, Jacob M ; Sabbaghi, Arman ; Carroll, Chad C</creatorcontrib><description>Tendon biomechanical properties and fibril organization are altered in patients with diabetes compared to healthy individuals, yet few biomarkers have been associated with in vivo tendon properties. We investigated the relationships between in vivo imaging-based tendon properties, serum variables, and patient characteristics across healthy controls (n = 14, age: 45 ± 5 years, body mass index [BMI]: 24 ± 1, hemoglobin A1c [HbA1c]: 5.3 ± 0.1%), prediabetes (n = 14, age: 54 ± 5 years, BMI: 29 ± 2; HbA1c: 5.7 ± 0.1), and type 2 diabetes (n = 13, age: 55 ± 3 years, BMI: 33 ± 2, HbA1c: 6.7 ± 0.3). We used ultrasound speckle-tracking and measurements from magnetic resonance imaging (MRI) to estimate the patellar tendon in vivo tangent modulus. Analysis of plasma c-peptide, interleukin-1β (IL-1β), IL-6, IL-8, tumor necrosis factor-α (TNF-α), adiponectin, leptin, insulin-like growth factor 1 (IGF-1), and C-reactive protein (CRP) was completed. We built regression models incorporating statistically significant covariates and indicators for the clinically defined groups. We found that tendon cross-sectional area normalized to body weight (BWN CSA) and modulus were lower in patients with type 2 diabetes than in healthy controls (p < 0.05). Our regression analysis revealed that a model that included BMI, leptin, high-density lipoprotein (HDL), low-density lipoprotein (LDL), age, and group explained ~70% of the variability in BWN CSA (R
= 0.70, p < 0.001). For modulus, including the main effects LDL, groups, HbA1c, age, BMI, cholesterol, IGF-1, c-peptide, leptin, and IL-6, accounted for ~54% of the variability in modulus (R
= 0.54, p < 0.05). While BWN CSA and modulus were lower in those with diabetes, group was a poor predicter of tendon properties when considering the selected covariates. These data highlight the multifactorial nature of tendon changes with diabetes and suggest that blood variables could be reliable predictors of tendon properties.</description><identifier>ISSN: 0736-0266</identifier><identifier>ISSN: 1554-527X</identifier><identifier>EISSN: 1554-527X</identifier><identifier>DOI: 10.1002/jor.25816</identifier><identifier>PMID: 38400550</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Biomechanical Phenomena ; Case-Control Studies ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - physiopathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Patellar Ligament - diagnostic imaging ; Prediabetic State - blood ; Prediabetic State - physiopathology ; Ultrasonography</subject><ispartof>Journal of orthopaedic research, 2024-08, Vol.42 (8), p.1653-1669</ispartof><rights>2024 The Authors. Journal of Orthopaedic Research® published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c280t-47c08c37da84a80b5b51662928d57f37eefd50754ae9afe49b9c3849dd9d34513</cites><orcidid>0000-0003-0152-5821</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38400550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Shivam H</creatorcontrib><creatorcontrib>Campbell, Nathan W C</creatorcontrib><creatorcontrib>Emenim, Chinonso E</creatorcontrib><creatorcontrib>Farino, Dominick O</creatorcontrib><creatorcontrib>Damen, Frederick W</creatorcontrib><creatorcontrib>Rispoli, Joseph V</creatorcontrib><creatorcontrib>Goergen, Craig J</creatorcontrib><creatorcontrib>Haus, Jacob M</creatorcontrib><creatorcontrib>Sabbaghi, Arman</creatorcontrib><creatorcontrib>Carroll, Chad C</creatorcontrib><title>Patellar tendon biomechanical and morphologic properties and their relationship to serum clinical variables in persons with prediabetes and type 2 diabetes</title><title>Journal of orthopaedic research</title><addtitle>J Orthop Res</addtitle><description>Tendon biomechanical properties and fibril organization are altered in patients with diabetes compared to healthy individuals, yet few biomarkers have been associated with in vivo tendon properties. We investigated the relationships between in vivo imaging-based tendon properties, serum variables, and patient characteristics across healthy controls (n = 14, age: 45 ± 5 years, body mass index [BMI]: 24 ± 1, hemoglobin A1c [HbA1c]: 5.3 ± 0.1%), prediabetes (n = 14, age: 54 ± 5 years, BMI: 29 ± 2; HbA1c: 5.7 ± 0.1), and type 2 diabetes (n = 13, age: 55 ± 3 years, BMI: 33 ± 2, HbA1c: 6.7 ± 0.3). We used ultrasound speckle-tracking and measurements from magnetic resonance imaging (MRI) to estimate the patellar tendon in vivo tangent modulus. Analysis of plasma c-peptide, interleukin-1β (IL-1β), IL-6, IL-8, tumor necrosis factor-α (TNF-α), adiponectin, leptin, insulin-like growth factor 1 (IGF-1), and C-reactive protein (CRP) was completed. We built regression models incorporating statistically significant covariates and indicators for the clinically defined groups. We found that tendon cross-sectional area normalized to body weight (BWN CSA) and modulus were lower in patients with type 2 diabetes than in healthy controls (p < 0.05). Our regression analysis revealed that a model that included BMI, leptin, high-density lipoprotein (HDL), low-density lipoprotein (LDL), age, and group explained ~70% of the variability in BWN CSA (R
= 0.70, p < 0.001). For modulus, including the main effects LDL, groups, HbA1c, age, BMI, cholesterol, IGF-1, c-peptide, leptin, and IL-6, accounted for ~54% of the variability in modulus (R
= 0.54, p < 0.05). While BWN CSA and modulus were lower in those with diabetes, group was a poor predicter of tendon properties when considering the selected covariates. These data highlight the multifactorial nature of tendon changes with diabetes and suggest that blood variables could be reliable predictors of tendon properties.</description><subject>Adult</subject><subject>Biomechanical Phenomena</subject><subject>Case-Control Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patellar Ligament - diagnostic imaging</subject><subject>Prediabetic State - blood</subject><subject>Prediabetic State - physiopathology</subject><subject>Ultrasonography</subject><issn>0736-0266</issn><issn>1554-527X</issn><issn>1554-527X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUtLxDAUhYMoOj4W_gHJUhcdb5Omj6UMvmBAFwruSprc2kjb1CSj-Fv8s8YZx9WFe8_54J5DyGkK8xSAXb5ZN2eiTPMdMkuFyBLBipddMoOC5wmwPD8gh96_AUCRsnKfHPAyAxACZuT7UQbse-lowFHbkTbGDqg6ORoleypHTQfrps729tUoOjk7oQsG_foUOjSOOuxlMHb0nZlosNSjWw1U9WbD-JDOyKaPFjPS6PZRST9N6CINdTxh2OK-JqSMbnfHZK-VvceTv3lEnm-unxZ3yfLh9n5xtUwUKyEkWaGgVLzQssxkCY1oRJrnrGKlFkXLC8RWCyhEJrGSLWZVU6kYQKV1pXkmUn5Ezjfc-N37Cn2oB-PVbyoj2pWveTTznEMOUXqxkSpnvXfY1pMzg3RfdQr1bxd17KJedxG1Z3_YVTOg_lduw-c_tXOIYQ</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Patel, Shivam H</creator><creator>Campbell, Nathan W C</creator><creator>Emenim, Chinonso E</creator><creator>Farino, Dominick O</creator><creator>Damen, Frederick W</creator><creator>Rispoli, Joseph V</creator><creator>Goergen, Craig J</creator><creator>Haus, Jacob M</creator><creator>Sabbaghi, Arman</creator><creator>Carroll, Chad C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0152-5821</orcidid></search><sort><creationdate>20240801</creationdate><title>Patellar tendon biomechanical and morphologic properties and their relationship to serum clinical variables in persons with prediabetes and type 2 diabetes</title><author>Patel, Shivam H ; Campbell, Nathan W C ; Emenim, Chinonso E ; Farino, Dominick O ; Damen, Frederick W ; Rispoli, Joseph V ; Goergen, Craig J ; Haus, Jacob M ; Sabbaghi, Arman ; Carroll, Chad C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-47c08c37da84a80b5b51662928d57f37eefd50754ae9afe49b9c3849dd9d34513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Biomechanical Phenomena</topic><topic>Case-Control Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patellar Ligament - diagnostic imaging</topic><topic>Prediabetic State - blood</topic><topic>Prediabetic State - physiopathology</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Shivam H</creatorcontrib><creatorcontrib>Campbell, Nathan W C</creatorcontrib><creatorcontrib>Emenim, Chinonso E</creatorcontrib><creatorcontrib>Farino, Dominick O</creatorcontrib><creatorcontrib>Damen, Frederick W</creatorcontrib><creatorcontrib>Rispoli, Joseph V</creatorcontrib><creatorcontrib>Goergen, Craig J</creatorcontrib><creatorcontrib>Haus, Jacob M</creatorcontrib><creatorcontrib>Sabbaghi, Arman</creatorcontrib><creatorcontrib>Carroll, Chad C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of orthopaedic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Shivam H</au><au>Campbell, Nathan W C</au><au>Emenim, Chinonso E</au><au>Farino, Dominick O</au><au>Damen, Frederick W</au><au>Rispoli, Joseph V</au><au>Goergen, Craig J</au><au>Haus, Jacob M</au><au>Sabbaghi, Arman</au><au>Carroll, Chad C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patellar tendon biomechanical and morphologic properties and their relationship to serum clinical variables in persons with prediabetes and type 2 diabetes</atitle><jtitle>Journal of orthopaedic research</jtitle><addtitle>J Orthop Res</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>42</volume><issue>8</issue><spage>1653</spage><epage>1669</epage><pages>1653-1669</pages><issn>0736-0266</issn><issn>1554-527X</issn><eissn>1554-527X</eissn><abstract>Tendon biomechanical properties and fibril organization are altered in patients with diabetes compared to healthy individuals, yet few biomarkers have been associated with in vivo tendon properties. We investigated the relationships between in vivo imaging-based tendon properties, serum variables, and patient characteristics across healthy controls (n = 14, age: 45 ± 5 years, body mass index [BMI]: 24 ± 1, hemoglobin A1c [HbA1c]: 5.3 ± 0.1%), prediabetes (n = 14, age: 54 ± 5 years, BMI: 29 ± 2; HbA1c: 5.7 ± 0.1), and type 2 diabetes (n = 13, age: 55 ± 3 years, BMI: 33 ± 2, HbA1c: 6.7 ± 0.3). We used ultrasound speckle-tracking and measurements from magnetic resonance imaging (MRI) to estimate the patellar tendon in vivo tangent modulus. Analysis of plasma c-peptide, interleukin-1β (IL-1β), IL-6, IL-8, tumor necrosis factor-α (TNF-α), adiponectin, leptin, insulin-like growth factor 1 (IGF-1), and C-reactive protein (CRP) was completed. We built regression models incorporating statistically significant covariates and indicators for the clinically defined groups. We found that tendon cross-sectional area normalized to body weight (BWN CSA) and modulus were lower in patients with type 2 diabetes than in healthy controls (p < 0.05). Our regression analysis revealed that a model that included BMI, leptin, high-density lipoprotein (HDL), low-density lipoprotein (LDL), age, and group explained ~70% of the variability in BWN CSA (R
= 0.70, p < 0.001). For modulus, including the main effects LDL, groups, HbA1c, age, BMI, cholesterol, IGF-1, c-peptide, leptin, and IL-6, accounted for ~54% of the variability in modulus (R
= 0.54, p < 0.05). While BWN CSA and modulus were lower in those with diabetes, group was a poor predicter of tendon properties when considering the selected covariates. These data highlight the multifactorial nature of tendon changes with diabetes and suggest that blood variables could be reliable predictors of tendon properties.</abstract><cop>United States</cop><pmid>38400550</pmid><doi>10.1002/jor.25816</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0003-0152-5821</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0736-0266 |
| ispartof | Journal of orthopaedic research, 2024-08, Vol.42 (8), p.1653-1669 |
| issn | 0736-0266 1554-527X 1554-527X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3075363060 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adult Biomechanical Phenomena Case-Control Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - physiopathology Female Humans Magnetic Resonance Imaging Male Middle Aged Patellar Ligament - diagnostic imaging Prediabetic State - blood Prediabetic State - physiopathology Ultrasonography |
| title | Patellar tendon biomechanical and morphologic properties and their relationship to serum clinical variables in persons with prediabetes and type 2 diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T06%3A22%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Patellar%20tendon%20biomechanical%20and%20morphologic%20properties%20and%20their%20relationship%20to%20serum%20clinical%20variables%20in%20persons%20with%20prediabetes%20and%20type%202%20diabetes&rft.jtitle=Journal%20of%20orthopaedic%20research&rft.au=Patel,%20Shivam%20H&rft.date=2024-08-01&rft.volume=42&rft.issue=8&rft.spage=1653&rft.epage=1669&rft.pages=1653-1669&rft.issn=0736-0266&rft.eissn=1554-527X&rft_id=info:doi/10.1002/jor.25816&rft_dat=%3Cproquest_cross%3E3075363060%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3075363060&rft_id=info:pmid/38400550&rfr_iscdi=true |