The relationship between male and female endogenous reproductive hormones levels and subjective cognitive decline score: A cross‐sectional analysis of the Pingyin cohort study
Objective Reproductive hormones might impact disease course in cognitive decline. We examined the association between male and female endogenous reproductive hormones and subjective cognitive decline (SCD) score. Design, Patients and Measurements A cross‐sectional study design was used with baseline...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2024-12, Vol.101 (6), p.659-668 |
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| creator | Wang, Qi Yu, Ruihong Fu, Chunying Li, Meiling Wang, Xiaoyi Zhu, Dongshan |
| description | Objective
Reproductive hormones might impact disease course in cognitive decline. We examined the association between male and female endogenous reproductive hormones and subjective cognitive decline (SCD) score.
Design, Patients and Measurements
A cross‐sectional study design was used with baseline data from the Pingyin cohort study, involving 1943 participants aged 45–70 years. Oestrogen (E2), testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured in females and E2 and testosterone were measured in males. We categorised hormones into three levels of low, intermediate and high level. The 9‐item subjective cognitive decline questionnaire (SCD‐Q9) scores were collected to assess the symptoms of SCD. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence interval (CI) between categorised hormone levels and SCD status. Multivariable linear regression models were also used.
Results
Overall, 1943 participants were involved and 1285 (66.1%) were female. The mean age at baseline was 59.1 (standard deviation 7.1) years. Women with high testosterone levels had a higher probability of having SCD compared with those with low testosterone levels (OR 1.43, 95% CI 1.01–2.05). Men with a high level of testosterone (0.59, 0.35–0.98) and high testosterone/E2 ratio (0.55, 0.33–0.90) were related to decreased chances of having SCD. Each one‐unit increase of testosterone was linked to reduced SCD score in males [(β: −.029, 95% CI (−0.052, −0.007)].
Conclusion
There was sex‐specific relationship between hormone levels and SCD abnormal. Those with higher testosterone levels in females may increase likelihood of experiencing SCD. Males with higher testosterone levels and higher testosterone/E2 ratio may be associated with reduced likelihood of SCD. The roles of endogenous reproductive hormone levels and their dynamic changes in cognitive function need further investigation. |
| doi_str_mv | 10.1111/cen.15104 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3074727669</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3074727669</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3134-f2c6825a56eaf2c4d348de8cc4fd01e3748ecf65c491a93d99c001e60663abae3</originalsourceid><addsrcrecordid>eNp1kc1u1DAUhS0EokNhwQsgS2zKIq0d_yRhV40KVKooi7KOPPbNjEeOPdhJq-x4BF6FV-JJcJOWBVK98ZX93WOfexB6S8kpzetMgz-lghL-DK0ok6IoSymeoxVhhBRESn6EXqW0J4SImlQv0RGrG1HSulyh3zc7wBGcGmzwaWcPeAPDHYDHvXKAlTe4g7kEb8IWfBhT5g8xmFEP9hbwLsQ-eEjYwS24NLekcbOH5VqHrbdzZUA76wEnHSJ8xOdYx5DSn5-_0j0avHK5V7kp2YRDh4f8sW_Wbyfrs0h-ZcBpGM30Gr3olEvw5mE_Rt8_XdysvxRX158v1-dXhWaU8aIrtaxLoYQElWtuGK8N1FrzzhAKrOI16E4KzRuqGmaaRpN8LvO4mNooYMfoZNHNXn-MkIa2t0mDc8pDHkLLSMWrspKyyej7_9B9GGP2kilaMkKbmolMfVio2XeErj1E26s4tZS09zm2Ocd2zjGz7x4Ux00P5h_5GFwGzhbgzjqYnlZq1xdfF8m_XM6sOA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3123019835</pqid></control><display><type>article</type><title>The relationship between male and female endogenous reproductive hormones levels and subjective cognitive decline score: A cross‐sectional analysis of the Pingyin cohort study</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Wang, Qi ; Yu, Ruihong ; Fu, Chunying ; Li, Meiling ; Wang, Xiaoyi ; Zhu, Dongshan</creator><creatorcontrib>Wang, Qi ; Yu, Ruihong ; Fu, Chunying ; Li, Meiling ; Wang, Xiaoyi ; Zhu, Dongshan</creatorcontrib><description>Objective
Reproductive hormones might impact disease course in cognitive decline. We examined the association between male and female endogenous reproductive hormones and subjective cognitive decline (SCD) score.
Design, Patients and Measurements
A cross‐sectional study design was used with baseline data from the Pingyin cohort study, involving 1943 participants aged 45–70 years. Oestrogen (E2), testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured in females and E2 and testosterone were measured in males. We categorised hormones into three levels of low, intermediate and high level. The 9‐item subjective cognitive decline questionnaire (SCD‐Q9) scores were collected to assess the symptoms of SCD. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence interval (CI) between categorised hormone levels and SCD status. Multivariable linear regression models were also used.
Results
Overall, 1943 participants were involved and 1285 (66.1%) were female. The mean age at baseline was 59.1 (standard deviation 7.1) years. Women with high testosterone levels had a higher probability of having SCD compared with those with low testosterone levels (OR 1.43, 95% CI 1.01–2.05). Men with a high level of testosterone (0.59, 0.35–0.98) and high testosterone/E2 ratio (0.55, 0.33–0.90) were related to decreased chances of having SCD. Each one‐unit increase of testosterone was linked to reduced SCD score in males [(β: −.029, 95% CI (−0.052, −0.007)].
Conclusion
There was sex‐specific relationship between hormone levels and SCD abnormal. Those with higher testosterone levels in females may increase likelihood of experiencing SCD. Males with higher testosterone levels and higher testosterone/E2 ratio may be associated with reduced likelihood of SCD. The roles of endogenous reproductive hormone levels and their dynamic changes in cognitive function need further investigation.</description><identifier>ISSN: 0300-0664</identifier><identifier>ISSN: 1365-2265</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.15104</identifier><identifier>PMID: 38952182</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Cognitive ability ; Cognitive Dysfunction - blood ; Cohort analysis ; Cohort Studies ; Cross-Sectional Studies ; Estradiol - blood ; Estrogens ; Estrogens - blood ; Female ; Females ; Follicle Stimulating Hormone - blood ; Follicle-stimulating hormone ; Hormones ; Humans ; Luteinizing hormone ; Luteinizing Hormone - blood ; Male ; Males ; Middle Aged ; oestrogen ; Regression analysis ; reproductive hormones ; subjective cognitive decline ; Surveys and Questionnaires ; Testosterone ; Testosterone - blood</subject><ispartof>Clinical endocrinology (Oxford), 2024-12, Vol.101 (6), p.659-668</ispartof><rights>2024 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3134-f2c6825a56eaf2c4d348de8cc4fd01e3748ecf65c491a93d99c001e60663abae3</cites><orcidid>0000-0002-0697-7432</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.15104$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.15104$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38952182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Yu, Ruihong</creatorcontrib><creatorcontrib>Fu, Chunying</creatorcontrib><creatorcontrib>Li, Meiling</creatorcontrib><creatorcontrib>Wang, Xiaoyi</creatorcontrib><creatorcontrib>Zhu, Dongshan</creatorcontrib><title>The relationship between male and female endogenous reproductive hormones levels and subjective cognitive decline score: A cross‐sectional analysis of the Pingyin cohort study</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Objective
Reproductive hormones might impact disease course in cognitive decline. We examined the association between male and female endogenous reproductive hormones and subjective cognitive decline (SCD) score.
Design, Patients and Measurements
A cross‐sectional study design was used with baseline data from the Pingyin cohort study, involving 1943 participants aged 45–70 years. Oestrogen (E2), testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured in females and E2 and testosterone were measured in males. We categorised hormones into three levels of low, intermediate and high level. The 9‐item subjective cognitive decline questionnaire (SCD‐Q9) scores were collected to assess the symptoms of SCD. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence interval (CI) between categorised hormone levels and SCD status. Multivariable linear regression models were also used.
Results
Overall, 1943 participants were involved and 1285 (66.1%) were female. The mean age at baseline was 59.1 (standard deviation 7.1) years. Women with high testosterone levels had a higher probability of having SCD compared with those with low testosterone levels (OR 1.43, 95% CI 1.01–2.05). Men with a high level of testosterone (0.59, 0.35–0.98) and high testosterone/E2 ratio (0.55, 0.33–0.90) were related to decreased chances of having SCD. Each one‐unit increase of testosterone was linked to reduced SCD score in males [(β: −.029, 95% CI (−0.052, −0.007)].
Conclusion
There was sex‐specific relationship between hormone levels and SCD abnormal. Those with higher testosterone levels in females may increase likelihood of experiencing SCD. Males with higher testosterone levels and higher testosterone/E2 ratio may be associated with reduced likelihood of SCD. The roles of endogenous reproductive hormone levels and their dynamic changes in cognitive function need further investigation.</description><subject>Aged</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - blood</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Estradiol - blood</subject><subject>Estrogens</subject><subject>Estrogens - blood</subject><subject>Female</subject><subject>Females</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Follicle-stimulating hormone</subject><subject>Hormones</subject><subject>Humans</subject><subject>Luteinizing hormone</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Males</subject><subject>Middle Aged</subject><subject>oestrogen</subject><subject>Regression analysis</subject><subject>reproductive hormones</subject><subject>subjective cognitive decline</subject><subject>Surveys and Questionnaires</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><issn>0300-0664</issn><issn>1365-2265</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS0EokNhwQsgS2zKIq0d_yRhV40KVKooi7KOPPbNjEeOPdhJq-x4BF6FV-JJcJOWBVK98ZX93WOfexB6S8kpzetMgz-lghL-DK0ok6IoSymeoxVhhBRESn6EXqW0J4SImlQv0RGrG1HSulyh3zc7wBGcGmzwaWcPeAPDHYDHvXKAlTe4g7kEb8IWfBhT5g8xmFEP9hbwLsQ-eEjYwS24NLekcbOH5VqHrbdzZUA76wEnHSJ8xOdYx5DSn5-_0j0avHK5V7kp2YRDh4f8sW_Wbyfrs0h-ZcBpGM30Gr3olEvw5mE_Rt8_XdysvxRX158v1-dXhWaU8aIrtaxLoYQElWtuGK8N1FrzzhAKrOI16E4KzRuqGmaaRpN8LvO4mNooYMfoZNHNXn-MkIa2t0mDc8pDHkLLSMWrspKyyej7_9B9GGP2kilaMkKbmolMfVio2XeErj1E26s4tZS09zm2Ocd2zjGz7x4Ux00P5h_5GFwGzhbgzjqYnlZq1xdfF8m_XM6sOA</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Wang, Qi</creator><creator>Yu, Ruihong</creator><creator>Fu, Chunying</creator><creator>Li, Meiling</creator><creator>Wang, Xiaoyi</creator><creator>Zhu, Dongshan</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0697-7432</orcidid></search><sort><creationdate>202412</creationdate><title>The relationship between male and female endogenous reproductive hormones levels and subjective cognitive decline score: A cross‐sectional analysis of the Pingyin cohort study</title><author>Wang, Qi ; Yu, Ruihong ; Fu, Chunying ; Li, Meiling ; Wang, Xiaoyi ; Zhu, Dongshan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3134-f2c6825a56eaf2c4d348de8cc4fd01e3748ecf65c491a93d99c001e60663abae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - blood</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Estradiol - blood</topic><topic>Estrogens</topic><topic>Estrogens - blood</topic><topic>Female</topic><topic>Females</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Follicle-stimulating hormone</topic><topic>Hormones</topic><topic>Humans</topic><topic>Luteinizing hormone</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Males</topic><topic>Middle Aged</topic><topic>oestrogen</topic><topic>Regression analysis</topic><topic>reproductive hormones</topic><topic>subjective cognitive decline</topic><topic>Surveys and Questionnaires</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Yu, Ruihong</creatorcontrib><creatorcontrib>Fu, Chunying</creatorcontrib><creatorcontrib>Li, Meiling</creatorcontrib><creatorcontrib>Wang, Xiaoyi</creatorcontrib><creatorcontrib>Zhu, Dongshan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Qi</au><au>Yu, Ruihong</au><au>Fu, Chunying</au><au>Li, Meiling</au><au>Wang, Xiaoyi</au><au>Zhu, Dongshan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between male and female endogenous reproductive hormones levels and subjective cognitive decline score: A cross‐sectional analysis of the Pingyin cohort study</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2024-12</date><risdate>2024</risdate><volume>101</volume><issue>6</issue><spage>659</spage><epage>668</epage><pages>659-668</pages><issn>0300-0664</issn><issn>1365-2265</issn><eissn>1365-2265</eissn><abstract>Objective
Reproductive hormones might impact disease course in cognitive decline. We examined the association between male and female endogenous reproductive hormones and subjective cognitive decline (SCD) score.
Design, Patients and Measurements
A cross‐sectional study design was used with baseline data from the Pingyin cohort study, involving 1943 participants aged 45–70 years. Oestrogen (E2), testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured in females and E2 and testosterone were measured in males. We categorised hormones into three levels of low, intermediate and high level. The 9‐item subjective cognitive decline questionnaire (SCD‐Q9) scores were collected to assess the symptoms of SCD. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence interval (CI) between categorised hormone levels and SCD status. Multivariable linear regression models were also used.
Results
Overall, 1943 participants were involved and 1285 (66.1%) were female. The mean age at baseline was 59.1 (standard deviation 7.1) years. Women with high testosterone levels had a higher probability of having SCD compared with those with low testosterone levels (OR 1.43, 95% CI 1.01–2.05). Men with a high level of testosterone (0.59, 0.35–0.98) and high testosterone/E2 ratio (0.55, 0.33–0.90) were related to decreased chances of having SCD. Each one‐unit increase of testosterone was linked to reduced SCD score in males [(β: −.029, 95% CI (−0.052, −0.007)].
Conclusion
There was sex‐specific relationship between hormone levels and SCD abnormal. Those with higher testosterone levels in females may increase likelihood of experiencing SCD. Males with higher testosterone levels and higher testosterone/E2 ratio may be associated with reduced likelihood of SCD. The roles of endogenous reproductive hormone levels and their dynamic changes in cognitive function need further investigation.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38952182</pmid><doi>10.1111/cen.15104</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0697-7432</orcidid></addata></record> |
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| ispartof | Clinical endocrinology (Oxford), 2024-12, Vol.101 (6), p.659-668 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Aged Cognitive ability Cognitive Dysfunction - blood Cohort analysis Cohort Studies Cross-Sectional Studies Estradiol - blood Estrogens Estrogens - blood Female Females Follicle Stimulating Hormone - blood Follicle-stimulating hormone Hormones Humans Luteinizing hormone Luteinizing Hormone - blood Male Males Middle Aged oestrogen Regression analysis reproductive hormones subjective cognitive decline Surveys and Questionnaires Testosterone Testosterone - blood |
| title | The relationship between male and female endogenous reproductive hormones levels and subjective cognitive decline score: A cross‐sectional analysis of the Pingyin cohort study |
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