Dysregulation of cholesterol homeostasis is an early signal of beta cell proteotoxicity characteristic of type 2 diabetes

Type 2 diabetes (T2D) is a common metabolic disease due to insufficient insulin secretion by pancreatic beta cells in the context of insulin resistance. Islet molecular pathology reveals a role for protein misfolding in beta cell dysfunction and loss with islet amyloid derived from islet amyloid pol...

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Veröffentlicht in:	Physiological genomics 2024-09, Vol.56 (9), p.621-633
Hauptverfasser:	Gurlo, Tatyana, Liu, Ruoshui, Wang, Zhongying, Hoang, Jonathan, Ryazantsev, Sergey, Daval, Marie, Butler, Alexandra E, Yang, Xia, Blencowe, Montgomery, Butler, Peter C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylin Beta cells Cell membranes Cholesterol Diabetes Diabetes mellitus (non-insulin dependent) Disease resistance Homeostasis Insulin Insulin resistance Insulin secretion Metabolic disorders Protein folding Toxicity Transgenic mice
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