Postpartum haemorrhage and risk of cardiovascular disease in later life: A population‐based record linkage cohort study
Objective To investigate the association between postpartum haemorrhage (PPH) and subsequent cardiovascular disease. Design Population‐based retrospective cohort study, using record linkage between Aberdeen Maternity and Neonatal Databank (AMND) and Scottish healthcare data sets. Setting Grampian re...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2024-11, Vol.131 (12), p.1705-1714 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | Latt, Su Mon Opondo, Charles Alderdice, Fiona Kurinczuk, Jennifer J. Rowe, Rachel |
| description | Objective
To investigate the association between postpartum haemorrhage (PPH) and subsequent cardiovascular disease.
Design
Population‐based retrospective cohort study, using record linkage between Aberdeen Maternity and Neonatal Databank (AMND) and Scottish healthcare data sets.
Setting
Grampian region, Scotland.
Population
A cohort of 70 904 women who gave birth after 24 weeks of gestation in the period 1986–2016.
Methods
We used extended Cox regression models to investigate the association between having had one or more occurrences of PPH in any (first or subsequent) births (exposure) and subsequent cardiovascular disease, adjusted for sociodemographic, medical, and pregnancy and birth‐related factors.
Main Outcome Measures
Cardiovascular disease identified from the prescription of selected cardiovascular medications, hospital discharge records or death from cardiovascular disease.
Results
In our cohort of 70 904 women (with 124 795 birth records), 25 177 women (36%) had at least one PPH. Compared with not having a PPH, having at least one PPH was associated with an increased risk of developing cardiovascular disease, as defined above, in the first year after birth (adjusted hazard ratio, aHR 1.96; 95% confidence interval, 95% CI 1.51–2.53; p |
| doi_str_mv | 10.1111/1471-0528.17896 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3074134927</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3074134927</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2966-f69bed1f1715b507a7a662ef817de83b6af6c721cab0135452dd49d7025e44743</originalsourceid><addsrcrecordid>eNqFkb1O3TAYQC1EVSjtzFZZYukS8L8TNkD9FRIMdLYc-0uvIYmDnbS6G4_AM_ZJ6sulDF3qxZZ1vqNPOggdUnJMyzmhQtOKSFYfU103agftv_zsPr1JRTir99CbnG8JoYoR_hrt8boRSvJ6H62vY54nm-ZlwCsLQ0xpZX8AtqPHKeQ7HDvsbPIh_rTZLb1N2IcMNgMOI-7tDAn3oYNTfIanOBVgDnH8_fDYFqQowMXkCzHebawurmKacZ4Xv36LXnW2z_Du-T5A3z99vLn4Ul1eff56cXZZOdYoVXWqacHTjmoqW0m01VYpBl1NtYeat8p2ymlGnW0J5VJI5r1ovCZMghBa8AP0YeudUrxfIM9mCNlB39sR4pINJ1pQLhqmC3r0D3oblzSW7QynVMhGMqUKdbKlXIo5J-jMlMJg09pQYjZVzKaB2TQwT1XKxPtn79IO4F_4vxkKILfAr9DD-n8-c_7taiv-A_3rmFU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3114595266</pqid></control><display><type>article</type><title>Postpartum haemorrhage and risk of cardiovascular disease in later life: A population‐based record linkage cohort study</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Latt, Su Mon ; Opondo, Charles ; Alderdice, Fiona ; Kurinczuk, Jennifer J. ; Rowe, Rachel</creator><creatorcontrib>Latt, Su Mon ; Opondo, Charles ; Alderdice, Fiona ; Kurinczuk, Jennifer J. ; Rowe, Rachel</creatorcontrib><description>Objective
To investigate the association between postpartum haemorrhage (PPH) and subsequent cardiovascular disease.
Design
Population‐based retrospective cohort study, using record linkage between Aberdeen Maternity and Neonatal Databank (AMND) and Scottish healthcare data sets.
Setting
Grampian region, Scotland.
Population
A cohort of 70 904 women who gave birth after 24 weeks of gestation in the period 1986–2016.
Methods
We used extended Cox regression models to investigate the association between having had one or more occurrences of PPH in any (first or subsequent) births (exposure) and subsequent cardiovascular disease, adjusted for sociodemographic, medical, and pregnancy and birth‐related factors.
Main Outcome Measures
Cardiovascular disease identified from the prescription of selected cardiovascular medications, hospital discharge records or death from cardiovascular disease.
Results
In our cohort of 70 904 women (with 124 795 birth records), 25 177 women (36%) had at least one PPH. Compared with not having a PPH, having at least one PPH was associated with an increased risk of developing cardiovascular disease, as defined above, in the first year after birth (adjusted hazard ratio, aHR 1.96; 95% confidence interval, 95% CI 1.51–2.53; p < 0.001). The association was attenuated over time, but strong evidence of increased risk remained at 2–5 years (aHR 1.19, 95% CI 1.11–1.30, P < 0.001) and at 6–15 years after giving birth (aHR 1.17, 95% CI 1.05–1.30, p = 0.005).
Conclusions
Compared with women who have never had a PPH, women who have had at least one episode of PPH are twice as likely to develop cardiovascular disease in the first year after birth, and some increased risk persists for up to 15 years.</description><identifier>ISSN: 1470-0328</identifier><identifier>ISSN: 1471-0528</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/1471-0528.17896</identifier><identifier>PMID: 38946538</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Birth ; cardiac ; Cardiovascular disease ; Cardiovascular diseases ; Cohort analysis ; health outcomes ; Hemorrhage ; hypertension ; mortality ; Neonates ; Population studies ; Postpartum ; postpartum haemorrhage ; Postpartum period ; pregnancy ; Regression analysis ; Scotland ; Womens health</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2024-11, Vol.131 (12), p.1705-1714</ispartof><rights>2024 The Author(s). published by John Wiley & Sons Ltd.</rights><rights>2024 The Author(s). BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2966-f69bed1f1715b507a7a662ef817de83b6af6c721cab0135452dd49d7025e44743</cites><orcidid>0000-0002-0368-8336 ; 0000-0003-2994-3240</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1471-0528.17896$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1471-0528.17896$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38946538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Latt, Su Mon</creatorcontrib><creatorcontrib>Opondo, Charles</creatorcontrib><creatorcontrib>Alderdice, Fiona</creatorcontrib><creatorcontrib>Kurinczuk, Jennifer J.</creatorcontrib><creatorcontrib>Rowe, Rachel</creatorcontrib><title>Postpartum haemorrhage and risk of cardiovascular disease in later life: A population‐based record linkage cohort study</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Objective
To investigate the association between postpartum haemorrhage (PPH) and subsequent cardiovascular disease.
Design
Population‐based retrospective cohort study, using record linkage between Aberdeen Maternity and Neonatal Databank (AMND) and Scottish healthcare data sets.
Setting
Grampian region, Scotland.
Population
A cohort of 70 904 women who gave birth after 24 weeks of gestation in the period 1986–2016.
Methods
We used extended Cox regression models to investigate the association between having had one or more occurrences of PPH in any (first or subsequent) births (exposure) and subsequent cardiovascular disease, adjusted for sociodemographic, medical, and pregnancy and birth‐related factors.
Main Outcome Measures
Cardiovascular disease identified from the prescription of selected cardiovascular medications, hospital discharge records or death from cardiovascular disease.
Results
In our cohort of 70 904 women (with 124 795 birth records), 25 177 women (36%) had at least one PPH. Compared with not having a PPH, having at least one PPH was associated with an increased risk of developing cardiovascular disease, as defined above, in the first year after birth (adjusted hazard ratio, aHR 1.96; 95% confidence interval, 95% CI 1.51–2.53; p < 0.001). The association was attenuated over time, but strong evidence of increased risk remained at 2–5 years (aHR 1.19, 95% CI 1.11–1.30, P < 0.001) and at 6–15 years after giving birth (aHR 1.17, 95% CI 1.05–1.30, p = 0.005).
Conclusions
Compared with women who have never had a PPH, women who have had at least one episode of PPH are twice as likely to develop cardiovascular disease in the first year after birth, and some increased risk persists for up to 15 years.</description><subject>Birth</subject><subject>cardiac</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cohort analysis</subject><subject>health outcomes</subject><subject>Hemorrhage</subject><subject>hypertension</subject><subject>mortality</subject><subject>Neonates</subject><subject>Population studies</subject><subject>Postpartum</subject><subject>postpartum haemorrhage</subject><subject>Postpartum period</subject><subject>pregnancy</subject><subject>Regression analysis</subject><subject>Scotland</subject><subject>Womens health</subject><issn>1470-0328</issn><issn>1471-0528</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNqFkb1O3TAYQC1EVSjtzFZZYukS8L8TNkD9FRIMdLYc-0uvIYmDnbS6G4_AM_ZJ6sulDF3qxZZ1vqNPOggdUnJMyzmhQtOKSFYfU103agftv_zsPr1JRTir99CbnG8JoYoR_hrt8boRSvJ6H62vY54nm-ZlwCsLQ0xpZX8AtqPHKeQ7HDvsbPIh_rTZLb1N2IcMNgMOI-7tDAn3oYNTfIanOBVgDnH8_fDYFqQowMXkCzHebawurmKacZ4Xv36LXnW2z_Du-T5A3z99vLn4Ul1eff56cXZZOdYoVXWqacHTjmoqW0m01VYpBl1NtYeat8p2ymlGnW0J5VJI5r1ovCZMghBa8AP0YeudUrxfIM9mCNlB39sR4pINJ1pQLhqmC3r0D3oblzSW7QynVMhGMqUKdbKlXIo5J-jMlMJg09pQYjZVzKaB2TQwT1XKxPtn79IO4F_4vxkKILfAr9DD-n8-c_7taiv-A_3rmFU</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Latt, Su Mon</creator><creator>Opondo, Charles</creator><creator>Alderdice, Fiona</creator><creator>Kurinczuk, Jennifer J.</creator><creator>Rowe, Rachel</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0368-8336</orcidid><orcidid>https://orcid.org/0000-0003-2994-3240</orcidid></search><sort><creationdate>202411</creationdate><title>Postpartum haemorrhage and risk of cardiovascular disease in later life: A population‐based record linkage cohort study</title><author>Latt, Su Mon ; Opondo, Charles ; Alderdice, Fiona ; Kurinczuk, Jennifer J. ; Rowe, Rachel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2966-f69bed1f1715b507a7a662ef817de83b6af6c721cab0135452dd49d7025e44743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Birth</topic><topic>cardiac</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cohort analysis</topic><topic>health outcomes</topic><topic>Hemorrhage</topic><topic>hypertension</topic><topic>mortality</topic><topic>Neonates</topic><topic>Population studies</topic><topic>Postpartum</topic><topic>postpartum haemorrhage</topic><topic>Postpartum period</topic><topic>pregnancy</topic><topic>Regression analysis</topic><topic>Scotland</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Latt, Su Mon</creatorcontrib><creatorcontrib>Opondo, Charles</creatorcontrib><creatorcontrib>Alderdice, Fiona</creatorcontrib><creatorcontrib>Kurinczuk, Jennifer J.</creatorcontrib><creatorcontrib>Rowe, Rachel</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Latt, Su Mon</au><au>Opondo, Charles</au><au>Alderdice, Fiona</au><au>Kurinczuk, Jennifer J.</au><au>Rowe, Rachel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postpartum haemorrhage and risk of cardiovascular disease in later life: A population‐based record linkage cohort study</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2024-11</date><risdate>2024</risdate><volume>131</volume><issue>12</issue><spage>1705</spage><epage>1714</epage><pages>1705-1714</pages><issn>1470-0328</issn><issn>1471-0528</issn><eissn>1471-0528</eissn><abstract>Objective
To investigate the association between postpartum haemorrhage (PPH) and subsequent cardiovascular disease.
Design
Population‐based retrospective cohort study, using record linkage between Aberdeen Maternity and Neonatal Databank (AMND) and Scottish healthcare data sets.
Setting
Grampian region, Scotland.
Population
A cohort of 70 904 women who gave birth after 24 weeks of gestation in the period 1986–2016.
Methods
We used extended Cox regression models to investigate the association between having had one or more occurrences of PPH in any (first or subsequent) births (exposure) and subsequent cardiovascular disease, adjusted for sociodemographic, medical, and pregnancy and birth‐related factors.
Main Outcome Measures
Cardiovascular disease identified from the prescription of selected cardiovascular medications, hospital discharge records or death from cardiovascular disease.
Results
In our cohort of 70 904 women (with 124 795 birth records), 25 177 women (36%) had at least one PPH. Compared with not having a PPH, having at least one PPH was associated with an increased risk of developing cardiovascular disease, as defined above, in the first year after birth (adjusted hazard ratio, aHR 1.96; 95% confidence interval, 95% CI 1.51–2.53; p < 0.001). The association was attenuated over time, but strong evidence of increased risk remained at 2–5 years (aHR 1.19, 95% CI 1.11–1.30, P < 0.001) and at 6–15 years after giving birth (aHR 1.17, 95% CI 1.05–1.30, p = 0.005).
Conclusions
Compared with women who have never had a PPH, women who have had at least one episode of PPH are twice as likely to develop cardiovascular disease in the first year after birth, and some increased risk persists for up to 15 years.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38946538</pmid><doi>10.1111/1471-0528.17896</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0368-8336</orcidid><orcidid>https://orcid.org/0000-0003-2994-3240</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | BJOG : an international journal of obstetrics and gynaecology, 2024-11, Vol.131 (12), p.1705-1714 |
| issn | 1470-0328 1471-0528 1471-0528 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3074134927 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Birth cardiac Cardiovascular disease Cardiovascular diseases Cohort analysis health outcomes Hemorrhage hypertension mortality Neonates Population studies Postpartum postpartum haemorrhage Postpartum period pregnancy Regression analysis Scotland Womens health |
| title | Postpartum haemorrhage and risk of cardiovascular disease in later life: A population‐based record linkage cohort study |
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