Effects of drug-induced liver injury on the in vivo fate of liposomes

[Display omitted] Liposomes represent one of the most extensively studied nano-carriers due to their potential in targeted drug delivery. However, the complex in vivo fate, particularly under pathological conditions, presents challenges for clinical translation of liposomal therapeutics. Liver serve...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2024-08, Vol.201, p.114389, Article 114389
Hauptverfasser:	Liu, Mengyuan, Wu, Ercan, Pan, Feng, Tian, Kaisong, Fu, Jiaru, Yu, Yifei, Guo, Zhiwei, Ma, Yinyu, Wei, Anqi, Yu, Xiaoyue, Zhan, Changyou, Qian, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - pharmacokinetics Animals Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Disease Models, Animal Diterpenes - administration & dosage Diterpenes - pharmacokinetics Drug Delivery Systems - methods Drug-induced liver injury Epoxy Compounds - administration & dosage Epoxy Compounds - pharmacokinetics Liposome Liposomes Liver - drug effects Liver - metabolism Macrophage Macrophages - drug effects Macrophages - metabolism Male Mice Mice, Inbred C57BL Phenanthrenes - administration & dosage Phenanthrenes - pharmacokinetics Phenanthrenes - toxicity Protein corona Tissue Distribution
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