Loss of Toll-like receptor 9 protects from hepatocellular carcinoma in murine models of chronic liver disease

Toll-like receptor 9 (Tlr9) is a pathogen recognition receptor detecting unmethylated DNA derivatives of pathogens and damaged host cells. It is therefore an important modulator of innate immunity. Here we investigated the role of Tlr9 in fibrogenesis and progression of hepatocellular carcinoma in c...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2024-10, Vol.1870 (7), p.167321, Article 167321
Hauptverfasser:	Hatten, Hannes, Colyn, Leticia, Volkert, Ines, Gaßler, Nikolaus, Lammers, Twan, Hofmann, Ute, Hengstler, Jan G., Schneider, Kai Markus, Trautwein, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Proliferation Chronic Disease Chronic liver disease DEN/CCl4 Disease Models, Animal Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Hepatocellular carcinoma Hepatocytes - metabolism Hepatocytes - pathology Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kupffer Cells - metabolism Kupffer Cells - pathology Liver - metabolism Liver - pathology Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver Diseases - genetics Liver Diseases - metabolism Liver Diseases - pathology Liver fibrosis Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Mice Mice, Inbred C57BL Mice, Knockout Toll-like receptor 9 Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism
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