Arsenic Induced Oxidative Neural-Damages in Rat are Mitigated by Tea-Leave Extract via MMPs and AChE Inactivation, Shown by Molecular Docking and in Vitro Studies with Pure Theaflavin and AChE

Background: Chronic arsenic-exposure causes neuromuscular disorders and other health anomalies. Damage to DNA and cytoskeletal/extracellular matrix is brought on by reactive-oxygen-species (ROS)-induced intrinsic antioxidant depletion (thiols/urate). Therapeutic chelating-agents have multiple side-e...

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Veröffentlicht in:	Cell biochemistry and biophysics 2024-09, Vol.82 (3), p.2567-2583
Hauptverfasser:	Medda, Nandita, Maiti, Sayantani, Acharyya, Nirmallya, Samanta, Tanmoy, Banerjee, Amrita, De, Subrata Kr, Ghosh, Tamal Kanti, Maiti, Smarajit
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - metabolism Allopurinol Animal tissues Animals Antioxidants Antioxidants - chemistry Antioxidants - metabolism Antioxidants - pharmacology Arsenic Arsenic - toxicity Biflavonoids - chemistry Biflavonoids - pharmacology Binding Biochemical analysis Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Brain - drug effects Brain - metabolism Brain damage Camellia sinensis Camellia sinensis - chemistry Catalase Catechin - analogs & derivatives Catechin - chemistry Catechin - pharmacology Cell Biology Cerebellum Cerebrum Chelation Cholinergics Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Comets Cytoskeleton Deactivation Deoxyribonucleic acid Depletion DNA DNA damage Exposure Extracellular matrix Free energy Gelatinase A Inactivation Life Sciences Locomotion Male Matrix metalloproteinase Matrix metalloproteinases Matrix Metalloproteinases - metabolism Molecular docking Molecular Docking Simulation Neuromuscular diseases Original Paper Oxidative Stress - drug effects Pharmacology Pharmacology/Toxicology Plant Extracts - chemistry Plant Extracts - pharmacology Rats Rats, Wistar Reactive oxygen species Superoxide dismutase Tea Tea - chemistry Theaflavins Thiols Toxicity Uric acid Uric Acid - metabolism
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