Tyrosine Sulfation Modulates the Binding Affinity of Chemokine-Targeting Nanobodies

Chemokines are an important family of small proteins integral to leukocyte recruitment during inflammation. Dysregulation of the chemokine–chemokine receptor axis is implicated in many diseases, and both chemokines and their cognate receptors have been the targets of therapeutic development. Analysi...

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Veröffentlicht in:ACS chemical biology 2024-07, Vol.19 (7), p.1426-1432
Hauptverfasser: Dilly, Joshua J., Morgan, Alexandra L., Bedding, Max J., Low, Jason K. K., Mackay, Joel P., Conibear, Anne C., Bhusal, Ram Prasad, Stone, Martin J., Franck, Charlotte, Payne, Richard J.
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