Fisetin-loaded pluronic-based nanogel: Radiation synthesis for alleviating neurocognitive impairments in a rat model of alzheimer's disease via modulation of the apoptotic cascade

Alzheimer's disease (AD) is a neurodegenerative disorder marked by cognitive impairment and memory loss. In this study, AD was experimentally induced in rats using aluminum chloride (AlCl3) and D-galactose (D-gal). Fisetin (Fis), a natural compound with antioxidant and anti-inflammatory propert...

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Veröffentlicht in:	International journal of biological macromolecules 2024-08, Vol.274 (Pt 2), p.133472, Article 133472
Hauptverfasser:	Deghiedy, Noha M., Abdel-Naby, Doaa H., Aziz, Maha M., El-Sheikh, Marwa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	AlCl3/D-gal Aluminum Chloride Alzheimer Disease - drug therapy Alzheimer's disease Animals Apoptosis Apoptosis - drug effects Cognitive Dysfunction - drug therapy Disease Models, Animal Drug Carriers - chemistry Fisetin Flavonoids - chemical synthesis Flavonoids - chemistry Flavonoids - pharmacology Flavonols - chemistry Flavonols - pharmacology Galactose - chemistry Male Nanogels - chemistry Neurocognitive impairments Pluronic-based nanogel Poloxamer - chemistry Rats Rats, Wistar
Online-Zugang:	Volltext
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