Label-guided seed-chain-extend alignment on annotated De Bruijn graphs

Abstract Motivation Exponential growth in sequencing databases has motivated scalable De Bruijn graph-based (DBG) indexing for searching these data, using annotations to label nodes with sample IDs. Low-depth sequencing samples correspond to fragmented subgraphs, complicating finding the long contig...

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Veröffentlicht in:	Bioinformatics (Oxford, England) England), 2024-06, Vol.40 (Supplement_1), p.i337-i346
Hauptverfasser:	Mustafa, Harun, Karasikov, Mikhail, Mansouri Ghiasi, Nika, Rätsch, Gunnar, Kahles, André
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Alignment Annotations Availability Biological effects Chains Computational Biology - methods Databases, Genetic Fragmentation Graph theory Graphs Labels Scoring models Sequence Alignment - methods Sequence Analysis, DNA - methods Software
Online-Zugang:	Volltext
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