Predictors of Optical Coherence Tomography-Defined Calcified Nodules in Patients With Acute Coronary Syndrome ― A Substudy From the TACTICS Registry
Background: Recent studies suggest that the presence of calcified nodules (CN) is associated with worse prognosis in patients with acute coronary syndrome (ACS). We investigated clinical predictors of optical coherence tomography (OCT)-defined CN in ACS patients in a prospective multicenter registry...
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| Veröffentlicht in: | Circulation Journal 2024/10/25, Vol.88(11), pp.1853-1861 |
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| creator | Sugiyama, Tomoyo Kakuta, Tsunekazu Hoshino, Masahiro Hada, Masahiro Yonetsu, Taishi Usui, Eisuke Hanyu, Yoshihiro Nagamine, Tatsuhiro Nogami, Kai Ueno, Hiroki Matsuda, Kazuki Sayama, Kodai Sakamoto, Tatsuya Kobayashi, Nobuaki Takano, Masamichi Kondo, Seita Wakabayashi, Kohei Suwa, Satoru Dohi, Tomotaka Mori, Hiroyoshi Kimura, Shigeki Mitomo, Satoru Nakamura, Sunao Higuma, Takumi Yamaguchi, Junichi Natsumeda, Makoto Ikari, Yuji Yamashita, Jun Sambe, Takehiko Yasuhara, Sakiko Mizukami, Takuya Yamamoto, Myong Hwa Sasano, Tetsuo Shinke, Toshiro Investigators, the TACTICS |
| description | Background: Recent studies suggest that the presence of calcified nodules (CN) is associated with worse prognosis in patients with acute coronary syndrome (ACS). We investigated clinical predictors of optical coherence tomography (OCT)-defined CN in ACS patients in a prospective multicenter registry.Methods and Results: We investigated 695 patients enrolled in the TACTICS registry who underwent OCT assessment of the culprit lesion during primary percutaneous coronary intervention. OCT-CN was defined as calcific nodules erupting into the lumen with disruption of the fibrous cap and an underlying calcified plate. Compared with patients without OCT-CN, patients with OCT-CN (n=28) were older (mean [±SD] age 75.0±11.3 vs. 65.7±12.7 years; P |
| doi_str_mv | 10.1253/circj.CJ-24-0111 |
| format | Article |
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We investigated clinical predictors of optical coherence tomography (OCT)-defined CN in ACS patients in a prospective multicenter registry.Methods and Results: We investigated 695 patients enrolled in the TACTICS registry who underwent OCT assessment of the culprit lesion during primary percutaneous coronary intervention. OCT-CN was defined as calcific nodules erupting into the lumen with disruption of the fibrous cap and an underlying calcified plate. Compared with patients without OCT-CN, patients with OCT-CN (n=28) were older (mean [±SD] age 75.0±11.3 vs. 65.7±12.7 years; P<0.001), had a higher prevalence of diabetes (50.0% vs. 29.4%; P=0.034), hemodialysis (21.4% vs. 1.6%; P<0.001), and Killip Class III/IV heart failure (21.4% vs. 5.7%; P=0.003), and a higher preprocedural SYNTAX score (median [interquartile range] score 15 [11–25] vs. 11 [7–19]; P=0.003). On multivariable analysis, age (odds ratio [OR] 1.072; P<0.001), hemodialysis (OR 16.571; P<0.001), and Killip Class III/IV (OR 4.466; P=0.004) were significantly associated with the presence of OCT-CN. In non-dialysis patients (n=678), age (OR 1.081; P<0.001), diabetes (OR 3.046; P=0.014), and Killip Class III/IV (OR 4.414; P=0.009) were significantly associated with the presence of OCT-CN.Conclusions: The TACTICS registry shows that OCT-CN is associated with lesion severity and poor clinical background, which may worsen prognosis.</description><identifier>ISSN: 1346-9843</identifier><identifier>ISSN: 1347-4820</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-24-0111</identifier><identifier>PMID: 38925928</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Acute coronary syndrome ; Calcified nodules ; Coronary artery disease ; Optical coherence tomography</subject><ispartof>Circulation Journal, 2024/10/25, Vol.88(11), pp.1853-1861</ispartof><rights>2024, THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c383t-a6f7f8615c5fa2bd3c93fd4b2dcd4d7016827f199e06aa0cc8dc72d55ae1e1f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38925928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugiyama, Tomoyo</creatorcontrib><creatorcontrib>Kakuta, Tsunekazu</creatorcontrib><creatorcontrib>Hoshino, Masahiro</creatorcontrib><creatorcontrib>Hada, Masahiro</creatorcontrib><creatorcontrib>Yonetsu, Taishi</creatorcontrib><creatorcontrib>Usui, Eisuke</creatorcontrib><creatorcontrib>Hanyu, Yoshihiro</creatorcontrib><creatorcontrib>Nagamine, Tatsuhiro</creatorcontrib><creatorcontrib>Nogami, Kai</creatorcontrib><creatorcontrib>Ueno, Hiroki</creatorcontrib><creatorcontrib>Matsuda, Kazuki</creatorcontrib><creatorcontrib>Sayama, Kodai</creatorcontrib><creatorcontrib>Sakamoto, Tatsuya</creatorcontrib><creatorcontrib>Kobayashi, Nobuaki</creatorcontrib><creatorcontrib>Takano, Masamichi</creatorcontrib><creatorcontrib>Kondo, Seita</creatorcontrib><creatorcontrib>Wakabayashi, Kohei</creatorcontrib><creatorcontrib>Suwa, Satoru</creatorcontrib><creatorcontrib>Dohi, Tomotaka</creatorcontrib><creatorcontrib>Mori, Hiroyoshi</creatorcontrib><creatorcontrib>Kimura, Shigeki</creatorcontrib><creatorcontrib>Mitomo, Satoru</creatorcontrib><creatorcontrib>Nakamura, Sunao</creatorcontrib><creatorcontrib>Higuma, Takumi</creatorcontrib><creatorcontrib>Yamaguchi, Junichi</creatorcontrib><creatorcontrib>Natsumeda, Makoto</creatorcontrib><creatorcontrib>Ikari, Yuji</creatorcontrib><creatorcontrib>Yamashita, Jun</creatorcontrib><creatorcontrib>Sambe, Takehiko</creatorcontrib><creatorcontrib>Yasuhara, Sakiko</creatorcontrib><creatorcontrib>Mizukami, Takuya</creatorcontrib><creatorcontrib>Yamamoto, Myong Hwa</creatorcontrib><creatorcontrib>Sasano, Tetsuo</creatorcontrib><creatorcontrib>Shinke, Toshiro</creatorcontrib><creatorcontrib>Investigators, the TACTICS</creatorcontrib><creatorcontrib>TACTICS Investigators</creatorcontrib><creatorcontrib>the TACTICS Investigators</creatorcontrib><title>Predictors of Optical Coherence Tomography-Defined Calcified Nodules in Patients With Acute Coronary Syndrome ― A Substudy From the TACTICS Registry</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background: Recent studies suggest that the presence of calcified nodules (CN) is associated with worse prognosis in patients with acute coronary syndrome (ACS). We investigated clinical predictors of optical coherence tomography (OCT)-defined CN in ACS patients in a prospective multicenter registry.Methods and Results: We investigated 695 patients enrolled in the TACTICS registry who underwent OCT assessment of the culprit lesion during primary percutaneous coronary intervention. OCT-CN was defined as calcific nodules erupting into the lumen with disruption of the fibrous cap and an underlying calcified plate. Compared with patients without OCT-CN, patients with OCT-CN (n=28) were older (mean [±SD] age 75.0±11.3 vs. 65.7±12.7 years; P<0.001), had a higher prevalence of diabetes (50.0% vs. 29.4%; P=0.034), hemodialysis (21.4% vs. 1.6%; P<0.001), and Killip Class III/IV heart failure (21.4% vs. 5.7%; P=0.003), and a higher preprocedural SYNTAX score (median [interquartile range] score 15 [11–25] vs. 11 [7–19]; P=0.003). On multivariable analysis, age (odds ratio [OR] 1.072; P<0.001), hemodialysis (OR 16.571; P<0.001), and Killip Class III/IV (OR 4.466; P=0.004) were significantly associated with the presence of OCT-CN. In non-dialysis patients (n=678), age (OR 1.081; P<0.001), diabetes (OR 3.046; P=0.014), and Killip Class III/IV (OR 4.414; P=0.009) were significantly associated with the presence of OCT-CN.Conclusions: The TACTICS registry shows that OCT-CN is associated with lesion severity and poor clinical background, which may worsen prognosis.</description><subject>Acute coronary syndrome</subject><subject>Calcified nodules</subject><subject>Coronary artery disease</subject><subject>Optical coherence tomography</subject><issn>1346-9843</issn><issn>1347-4820</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpFkU1P3DAQhqOqqFDovafKx15C_ZEP57hKgYIQIHZRj5bXHm-8SuKt7Rxy2z9Rqb-v_SPNsgtcZkbWM8_IepPkM8HnhObsm7Jerc_rm5RmKSaEvEtOCMvKNOMUv3-ei7TiGTtOPoawxphWOK8-JMeMVzSvKD9J_jx40FZF5wNyBt1volWyRbVrwEOvAC1c51Zebpox_Q7G9qBRLVtljZ2mO6eHFgKyPXqQ0UIfA_ppY4NmaogwWbzrpR_RfOy1dx38227_bn-jGZoPyxAHPaLL6RnFZrozqxfX9Rw9wsqG6Mez5MjINsCnQz9Nni4vFvWP9Pb-6rqe3aaKcRZTWZjS8ILkKjeSLjVTFTM6W1KtdKZLTApOS0OqCnAhJVaKa1VSnecSCBDD2Gnyde_dePdrgBBFZ4OCtpU9uCEIhkvKMS1oMaF4jyrvQvBgxMbbbvqfIFjs8hDPeYj6RtBM7PKYVr4c7MOyA_268BLABFztgXWIcgWvgPRTEC0cjJwLQnb1Tf1GNNIL6Nl_ywGlJQ</recordid><startdate>20241025</startdate><enddate>20241025</enddate><creator>Sugiyama, Tomoyo</creator><creator>Kakuta, Tsunekazu</creator><creator>Hoshino, Masahiro</creator><creator>Hada, Masahiro</creator><creator>Yonetsu, Taishi</creator><creator>Usui, Eisuke</creator><creator>Hanyu, Yoshihiro</creator><creator>Nagamine, Tatsuhiro</creator><creator>Nogami, Kai</creator><creator>Ueno, Hiroki</creator><creator>Matsuda, Kazuki</creator><creator>Sayama, Kodai</creator><creator>Sakamoto, Tatsuya</creator><creator>Kobayashi, Nobuaki</creator><creator>Takano, Masamichi</creator><creator>Kondo, Seita</creator><creator>Wakabayashi, Kohei</creator><creator>Suwa, Satoru</creator><creator>Dohi, Tomotaka</creator><creator>Mori, Hiroyoshi</creator><creator>Kimura, Shigeki</creator><creator>Mitomo, Satoru</creator><creator>Nakamura, Sunao</creator><creator>Higuma, Takumi</creator><creator>Yamaguchi, Junichi</creator><creator>Natsumeda, Makoto</creator><creator>Ikari, Yuji</creator><creator>Yamashita, Jun</creator><creator>Sambe, Takehiko</creator><creator>Yasuhara, Sakiko</creator><creator>Mizukami, Takuya</creator><creator>Yamamoto, Myong Hwa</creator><creator>Sasano, Tetsuo</creator><creator>Shinke, Toshiro</creator><creator>Investigators, the TACTICS</creator><general>The Japanese Circulation Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241025</creationdate><title>Predictors of Optical Coherence Tomography-Defined Calcified Nodules in Patients With Acute Coronary Syndrome ― A Substudy From the TACTICS Registry</title><author>Sugiyama, Tomoyo ; Kakuta, Tsunekazu ; Hoshino, Masahiro ; Hada, Masahiro ; Yonetsu, Taishi ; Usui, Eisuke ; Hanyu, Yoshihiro ; Nagamine, Tatsuhiro ; Nogami, Kai ; Ueno, Hiroki ; Matsuda, Kazuki ; Sayama, Kodai ; Sakamoto, Tatsuya ; Kobayashi, Nobuaki ; Takano, Masamichi ; Kondo, Seita ; Wakabayashi, Kohei ; Suwa, Satoru ; Dohi, Tomotaka ; Mori, Hiroyoshi ; Kimura, Shigeki ; Mitomo, Satoru ; Nakamura, Sunao ; Higuma, Takumi ; Yamaguchi, Junichi ; Natsumeda, Makoto ; Ikari, Yuji ; Yamashita, Jun ; Sambe, Takehiko ; Yasuhara, Sakiko ; Mizukami, Takuya ; Yamamoto, Myong Hwa ; Sasano, Tetsuo ; Shinke, Toshiro ; Investigators, the TACTICS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-a6f7f8615c5fa2bd3c93fd4b2dcd4d7016827f199e06aa0cc8dc72d55ae1e1f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acute coronary syndrome</topic><topic>Calcified nodules</topic><topic>Coronary artery disease</topic><topic>Optical coherence tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sugiyama, Tomoyo</creatorcontrib><creatorcontrib>Kakuta, Tsunekazu</creatorcontrib><creatorcontrib>Hoshino, Masahiro</creatorcontrib><creatorcontrib>Hada, Masahiro</creatorcontrib><creatorcontrib>Yonetsu, Taishi</creatorcontrib><creatorcontrib>Usui, Eisuke</creatorcontrib><creatorcontrib>Hanyu, Yoshihiro</creatorcontrib><creatorcontrib>Nagamine, Tatsuhiro</creatorcontrib><creatorcontrib>Nogami, Kai</creatorcontrib><creatorcontrib>Ueno, Hiroki</creatorcontrib><creatorcontrib>Matsuda, Kazuki</creatorcontrib><creatorcontrib>Sayama, Kodai</creatorcontrib><creatorcontrib>Sakamoto, Tatsuya</creatorcontrib><creatorcontrib>Kobayashi, Nobuaki</creatorcontrib><creatorcontrib>Takano, Masamichi</creatorcontrib><creatorcontrib>Kondo, Seita</creatorcontrib><creatorcontrib>Wakabayashi, Kohei</creatorcontrib><creatorcontrib>Suwa, Satoru</creatorcontrib><creatorcontrib>Dohi, Tomotaka</creatorcontrib><creatorcontrib>Mori, Hiroyoshi</creatorcontrib><creatorcontrib>Kimura, Shigeki</creatorcontrib><creatorcontrib>Mitomo, Satoru</creatorcontrib><creatorcontrib>Nakamura, Sunao</creatorcontrib><creatorcontrib>Higuma, Takumi</creatorcontrib><creatorcontrib>Yamaguchi, Junichi</creatorcontrib><creatorcontrib>Natsumeda, Makoto</creatorcontrib><creatorcontrib>Ikari, Yuji</creatorcontrib><creatorcontrib>Yamashita, Jun</creatorcontrib><creatorcontrib>Sambe, Takehiko</creatorcontrib><creatorcontrib>Yasuhara, Sakiko</creatorcontrib><creatorcontrib>Mizukami, Takuya</creatorcontrib><creatorcontrib>Yamamoto, Myong Hwa</creatorcontrib><creatorcontrib>Sasano, Tetsuo</creatorcontrib><creatorcontrib>Shinke, Toshiro</creatorcontrib><creatorcontrib>Investigators, the TACTICS</creatorcontrib><creatorcontrib>TACTICS Investigators</creatorcontrib><creatorcontrib>the TACTICS Investigators</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugiyama, Tomoyo</au><au>Kakuta, Tsunekazu</au><au>Hoshino, Masahiro</au><au>Hada, Masahiro</au><au>Yonetsu, Taishi</au><au>Usui, Eisuke</au><au>Hanyu, Yoshihiro</au><au>Nagamine, Tatsuhiro</au><au>Nogami, Kai</au><au>Ueno, Hiroki</au><au>Matsuda, Kazuki</au><au>Sayama, Kodai</au><au>Sakamoto, Tatsuya</au><au>Kobayashi, Nobuaki</au><au>Takano, Masamichi</au><au>Kondo, Seita</au><au>Wakabayashi, Kohei</au><au>Suwa, Satoru</au><au>Dohi, Tomotaka</au><au>Mori, Hiroyoshi</au><au>Kimura, Shigeki</au><au>Mitomo, Satoru</au><au>Nakamura, Sunao</au><au>Higuma, Takumi</au><au>Yamaguchi, Junichi</au><au>Natsumeda, Makoto</au><au>Ikari, Yuji</au><au>Yamashita, Jun</au><au>Sambe, Takehiko</au><au>Yasuhara, Sakiko</au><au>Mizukami, Takuya</au><au>Yamamoto, Myong Hwa</au><au>Sasano, Tetsuo</au><au>Shinke, Toshiro</au><au>Investigators, the TACTICS</au><aucorp>TACTICS Investigators</aucorp><aucorp>the TACTICS Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of Optical Coherence Tomography-Defined Calcified Nodules in Patients With Acute Coronary Syndrome ― A Substudy From the TACTICS Registry</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2024-10-25</date><risdate>2024</risdate><volume>88</volume><issue>11</issue><spage>1853</spage><epage>1861</epage><pages>1853-1861</pages><artnum>CJ-24-0111</artnum><issn>1346-9843</issn><issn>1347-4820</issn><eissn>1347-4820</eissn><abstract>Background: Recent studies suggest that the presence of calcified nodules (CN) is associated with worse prognosis in patients with acute coronary syndrome (ACS). We investigated clinical predictors of optical coherence tomography (OCT)-defined CN in ACS patients in a prospective multicenter registry.Methods and Results: We investigated 695 patients enrolled in the TACTICS registry who underwent OCT assessment of the culprit lesion during primary percutaneous coronary intervention. OCT-CN was defined as calcific nodules erupting into the lumen with disruption of the fibrous cap and an underlying calcified plate. Compared with patients without OCT-CN, patients with OCT-CN (n=28) were older (mean [±SD] age 75.0±11.3 vs. 65.7±12.7 years; P<0.001), had a higher prevalence of diabetes (50.0% vs. 29.4%; P=0.034), hemodialysis (21.4% vs. 1.6%; P<0.001), and Killip Class III/IV heart failure (21.4% vs. 5.7%; P=0.003), and a higher preprocedural SYNTAX score (median [interquartile range] score 15 [11–25] vs. 11 [7–19]; P=0.003). On multivariable analysis, age (odds ratio [OR] 1.072; P<0.001), hemodialysis (OR 16.571; P<0.001), and Killip Class III/IV (OR 4.466; P=0.004) were significantly associated with the presence of OCT-CN. In non-dialysis patients (n=678), age (OR 1.081; P<0.001), diabetes (OR 3.046; P=0.014), and Killip Class III/IV (OR 4.414; P=0.009) were significantly associated with the presence of OCT-CN.Conclusions: The TACTICS registry shows that OCT-CN is associated with lesion severity and poor clinical background, which may worsen prognosis.</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>38925928</pmid><doi>10.1253/circj.CJ-24-0111</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation Journal, 2024/10/25, Vol.88(11), pp.1853-1861 |
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| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acute coronary syndrome Calcified nodules Coronary artery disease Optical coherence tomography |
| title | Predictors of Optical Coherence Tomography-Defined Calcified Nodules in Patients With Acute Coronary Syndrome ― A Substudy From the TACTICS Registry |
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