Mammary adipocytes promote breast tumor cell invasion and angiogenesis in the context of menopause and obesity

The mechanism(s) underlying obesity-related postmenopausal (PM) breast cancer (BC) are not clearly understood. We hypothesized that the increased local presence of ‘obese’ mammary adipocytes within the BC microenvironment promotes the acquisition of an invasive and angiogenic BC cell phenotype and a...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2024-10, Vol.1870 (7), p.167325, Article 167325
Hauptverfasser:	Roy, Roopali, Man, Emily, Aldakhlallah, Rama, Gonzalez, Katherine, Merritt, Lauren, Daisy, Cassandra, Lombardo, Michael, Yordanova, Victoria, Sun, Liang, Isaac, Biju, Rockowitz, Shira, Lotz, Margaret, Pories, Susan, Moses, Marsha A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - metabolism Adipocytes - pathology Angiogenesis Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Movement Cell Proliferation Female Humans Interleukin-6 - metabolism Lipocalin-2 - genetics Lipocalin-2 - metabolism Mammary adipocyte Menopause - metabolism Middle Aged Neoplasm Invasiveness Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Obesity Obesity - metabolism Obesity - pathology Proto-Oncogene Proteins c-akt - metabolism Signal Transduction STAT3 Transcription Factor - metabolism Tumor Microenvironment
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