The Influence of Size on the Intracranial Distribution of Biomedical Nanoparticles Administered by Convection-enhanced Delivery in Minipigs

Because of the blood–brain barrier (BBB), successful drug delivery to the brain has long been a key objective for the medical community, calling for pioneering technologies to overcome this challenge. Convection-enhanced delivery (CED), a form of direct intraparenchymal microinfusion, shows promise...

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Veröffentlicht in:ACS nano 2024-07, Vol.18 (27), p.17869-17881
Hauptverfasser: Amirrashedi, Mahsa, Jensen, Andreas Ingemann, Tang, Qing, Straathof, Natan Johannes Willem, Ravn, Katharina, Pedersen, Christian G.T., Langhorn, Louise, Poulsen, Frantz Rom, Woolley, Max, Johnson, David, Williams, Julia, Kidd, Charlotte, Thisgaard, Helge, Halle, Bo
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Sprache:eng
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