Synthesis, preclinical evaluation and pilot clinical translation of 68GaGa-PMD22, a novel nanobody PET probe targeting CLDN18.2 of gastrointestinal cancer

Claudin18.2 (CLDN18.2) is a novel target for diagnosis and therapy of gastrointestinal cancer. This study aimed to evaluate the safety and feasibility of a novel CLDN18.2-targeted nanobody, PMD22, labeled with gallium-68 ([68Ga]Ga), for detecting CLDN18.2 expression in patients with gastrointestinal...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2024-10, Vol.51 (12), p.3731
Hauptverfasser:	Wang, Rongxi, Bai, Zhidong, Zhong, Wentao, Li, Chenzhen, Wang, Jiarou, Xiang, Jialin, Du, Junfeng, Jia, Bing, Zhu, Zhaohui
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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