3-O-acylated bile acids: disrupters or harmonizers of metabolism?
Unveiling a metabolic mystery, this article explores how 3-O-acylated bile acids, specifically 3-O-succinylated cholic acid (3-sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our...
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| creator | Chen, Runzhi Chen, Xinhua Gao, Jiangtao |
| description | Unveiling a metabolic mystery, this article explores how 3-O-acylated bile acids, specifically 3-O-succinylated cholic acid (3-sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D).
Unveiling a metabolic mystery, this article explores how 3-O-acylated bile acids, specifically 3-O-succinylated cholic acid (3-sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D). |
| doi_str_mv | 10.1016/j.molmed.2024.06.003 |
| format | Article |
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Unveiling a metabolic mystery, this article explores how 3-O-acylated bile acids, specifically 3-O-succinylated cholic acid (3-sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D).</description><identifier>ISSN: 1471-4914</identifier><identifier>ISSN: 1471-499X</identifier><identifier>EISSN: 1471-499X</identifier><identifier>DOI: 10.1016/j.molmed.2024.06.003</identifier><identifier>PMID: 38926031</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>bile acids ; gut microbes ; metabolic disorders ; metabolism-associated fatty liver disease ; type 2 diabetes</subject><ispartof>Trends in molecular medicine, 2024-06</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1561-166fa6ca3d37d499de929a3054424a3fb7573860414c4f3a2ddc6db07a26fd3b3</cites><orcidid>0000-0002-9669-4718</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.molmed.2024.06.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38926031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Runzhi</creatorcontrib><creatorcontrib>Chen, Xinhua</creatorcontrib><creatorcontrib>Gao, Jiangtao</creatorcontrib><title>3-O-acylated bile acids: disrupters or harmonizers of metabolism?</title><title>Trends in molecular medicine</title><addtitle>Trends Mol Med</addtitle><description>Unveiling a metabolic mystery, this article explores how 3-O-acylated bile acids, specifically 3-O-succinylated cholic acid (3-sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D).
Unveiling a metabolic mystery, this article explores how 3-O-acylated bile acids, specifically 3-O-succinylated cholic acid (3-sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D).</description><subject>bile acids</subject><subject>gut microbes</subject><subject>metabolic disorders</subject><subject>metabolism-associated fatty liver disease</subject><subject>type 2 diabetes</subject><issn>1471-4914</issn><issn>1471-499X</issn><issn>1471-499X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PwzAMhiMEYmPwDxDqkUuL89Fk5QCaJr6kSbuAxC1Kk1RkapeRtEjj19PRjSMn2_Jrv_aD0CWGDAPmN6us8XVjTUaAsAx4BkCP0BgzgVNWFO_HfzlmI3QW4woA50JMT9GITgvCgeIxmtF0mSq9rVVrTVK62iZKOxNvE-Ni6DatDTHxIflQofFr9_1bVkljW1X62sXm_hydVKqO9mIfJ-jt8eF1_pwulk8v89ki1TjnOMWcV4prRQ0Vpr_P2IIUikLOGGGKVqXIBZ1yYJhpVlFFjNHclCAU4ZWhJZ2g62HvJvjPzsZWNi5qW9dqbX0XJQVBpoApKXopG6Q6-BiDreQmuEaFrcQgd_DkSg7w5A6eBC57eP3Y1d6hK3e9w9CBVi-4GwS2__PL2SCjdnatrXHB6lYa7_53-AFyeYEF</recordid><startdate>20240625</startdate><enddate>20240625</enddate><creator>Chen, Runzhi</creator><creator>Chen, Xinhua</creator><creator>Gao, Jiangtao</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9669-4718</orcidid></search><sort><creationdate>20240625</creationdate><title>3-O-acylated bile acids: disrupters or harmonizers of metabolism?</title><author>Chen, Runzhi ; Chen, Xinhua ; Gao, Jiangtao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1561-166fa6ca3d37d499de929a3054424a3fb7573860414c4f3a2ddc6db07a26fd3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>bile acids</topic><topic>gut microbes</topic><topic>metabolic disorders</topic><topic>metabolism-associated fatty liver disease</topic><topic>type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Runzhi</creatorcontrib><creatorcontrib>Chen, Xinhua</creatorcontrib><creatorcontrib>Gao, Jiangtao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Runzhi</au><au>Chen, Xinhua</au><au>Gao, Jiangtao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3-O-acylated bile acids: disrupters or harmonizers of metabolism?</atitle><jtitle>Trends in molecular medicine</jtitle><addtitle>Trends Mol Med</addtitle><date>2024-06-25</date><risdate>2024</risdate><issn>1471-4914</issn><issn>1471-499X</issn><eissn>1471-499X</eissn><abstract>Unveiling a metabolic mystery, this article explores how 3-O-acylated bile acids, specifically 3-O-succinylated cholic acid (3-sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D).
Unveiling a metabolic mystery, this article explores how 3-O-acylated bile acids, specifically 3-O-succinylated cholic acid (3-sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D).</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38926031</pmid><doi>10.1016/j.molmed.2024.06.003</doi><orcidid>https://orcid.org/0000-0002-9669-4718</orcidid></addata></record> |
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| language | eng |
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| subjects | bile acids gut microbes metabolic disorders metabolism-associated fatty liver disease type 2 diabetes |
| title | 3-O-acylated bile acids: disrupters or harmonizers of metabolism? |
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