Disrupted stress‐induced analgesia in a neuropathic pain state is rescued by the endocannabinoid degradation inhibitor JZL195

Acute stress normally engages descending brain pathways to produce an antinociceptive response, known as stress‐induced analgesia. Paradoxically, these descending pain modulatory pathways are also involved in the maintenance of the abnormal pain associated with chronic neuropathic pain. It remains u...

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Veröffentlicht in:Journal of neurochemistry 2024-11, Vol.168 (11), p.3801-3812
Hauptverfasser: Atwal, Nicholas, Sokolaj, Eddy, Mitchell, Vanessa A., Winters, Bryony L., Vaughan, Christopher W.
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Sprache:eng
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