Elucidation of the Reversible Self-Association Interface of a Diabody–Interleukin Fusion Protein Using Hydrogen-Exchange Mass Spectrometry and In Silico Modeling

Reversible self-association (RSA) of therapeutic proteins presents major challenges in the development of high-concentration formulations, especially those intended for subcutaneous administration. Understanding self-association mechanisms is therefore critical to the design and selection of candida...

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Veröffentlicht in:	Molecular pharmaceutics 2024-09, Vol.21 (9), p.4285-4296
Hauptverfasser:	Eisinger, Martin, Rahn, Harri, Chen, Yong, Fernandes, Melissa, Lin, Zhiyi, Hentze, Nikolai, Tavella, Davide, Moussa, Ehab M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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