Automated Tomographic Assessment of Structural Defects of Freeze-Dried Pharmaceuticals
The topology and surface characteristics of lyophilisates significantly impact the stability and reconstitutability of freeze-dried pharmaceuticals. Consequently, visual quality control of the product is imperative. However, this procedure is not only time-consuming and labor-intensive but also expe...
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| Veröffentlicht in: | AAPS PharmSciTech 2024-06, Vol.25 (6), p.143, Article 143 |
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| container_title | AAPS PharmSciTech |
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| creator | Müller, Patric Sack, Achim Dümler, Jens Heckel, Michael Wenzel, Tim Siegert, Teresa Schuldt-Lieb, Sonja Gieseler, Henning Pöschel, Thorsten |
| description | The topology and surface characteristics of lyophilisates significantly impact the stability and reconstitutability of freeze-dried pharmaceuticals. Consequently, visual quality control of the product is imperative. However, this procedure is not only time-consuming and labor-intensive but also expensive and prone to errors. In this paper, we present an approach for fully automated, non-destructive inspection of freeze-dried pharmaceuticals, leveraging robotics, computed tomography, and machine learning. |
| doi_str_mv | 10.1208/s12249-024-02833-7 |
| format | Article |
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| subjects | Automation - methods Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Chemistry, Pharmaceutical - methods Freeze Drying - methods Machine Learning Pharmaceutical Preparations - chemistry Pharmacology/Toxicology Pharmacy Quality Control Research Article Robotics - methods Technology, Pharmaceutical - methods Tomography, X-Ray Computed - methods |
| title | Automated Tomographic Assessment of Structural Defects of Freeze-Dried Pharmaceuticals |
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