Silybin protected from avermectin-induced carp (Cyprinus carpio) nephrotoxicity by regulating PPAR-γ-involved inflammation, oxidative stress, ferroptosis and autophagy

•SYB attenuated the inflammatory damage caused by AVM via the NF-κB pathway.•SYB relieved kidney oxidative damage via Nrf2/Keap-1 pathway.•SYB alleviated kidney injury caused by AVM through ferroptosis.•SYB attenuated AVM-induced renal autophagy in carp via the PI3K/AKT pathway. Avermectin, a widely...

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Veröffentlicht in:	Aquatic toxicology 2024-08, Vol.273, p.107011, Article 107011
Hauptverfasser:	Gan, Jiajie, Ji, Xiaomeng, Jin, Xiaohui, Zhou, Mengyuan, Yang, Chenbeibei, Chen, Ziyun, Yin, Chaoyang, Dong, Zibo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Autophagy - drug effects Avermectin Carps Ferroptosis Ferroptosis - drug effects Fish Diseases - chemically induced Inflammation - chemically induced Inflammation - drug therapy Ivermectin - analogs & derivatives Ivermectin - toxicity Kidney - drug effects Kidney - pathology Oxidative stress Oxidative Stress - drug effects PPAR gamma - genetics PPAR gamma - metabolism Reactive Oxygen Species - metabolism Silybin Silybin - pharmacology Water Pollutants, Chemical - toxicity
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