G protein-coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling

The stabilization of different active conformations of G protein-coupled receptors is thought to underlie the varying efficacies of biased and balanced agonists. Here, profiling the activation of signal transducers by angiotensin II type 1 receptor (AT R) agonists revealed that the extent and kineti...

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Veröffentlicht in:	Science signaling 2024-06, Vol.17 (842), p.eadi0934
Hauptverfasser:	Tóth, András D, Szalai, Bence, Kovács, Orsolya T, Garger, Dániel, Prokop, Susanne, Soltész-Katona, Eszter, Balla, András, Inoue, Asuka, Várnai, Péter, Turu, Gábor, Hunyady, László
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Angiotensin AT1 receptors Angiotensin II Animals Arrestin beta-Arrestins - genetics beta-Arrestins - metabolism Drug delivery Drug development Endocytosis Endocytosis - physiology Endosomes - metabolism G protein-coupled receptors HEK293 Cells Humans Ligands Protein Binding Protein Transport Proteins Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 1 - metabolism Receptors Receptors, Adrenergic, beta-2 - genetics Receptors, Adrenergic, beta-2 - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Vasopressin - genetics Receptors, Vasopressin - metabolism Side effects Signal Transduction
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