A 21‐bp deletion in the complement regulator CD55 promotor region is associated with multifocal motor neuropathy and its disease course

Background and Aims To further substantiate the role of antibody‐mediated complement activation in multifocal motor neuropathy (MMN) immunopathology, we investigated the distribution of promotor polymorphisms of genes encoding the membrane‐bound complement regulators CD46, CD55, and CD59 in patients...

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Veröffentlicht in:	Journal of the peripheral nervous system 2024-06, Vol.29 (2), p.193-201
Hauptverfasser:	Bos, Jeroen W., Groen, Ewout J. N., Otten, Henny G., Budding, Kevin, Eijk, Ruben P. A., Curial, Chantall, Kardol‐Hoefnagel, Tineke, Goedee, H. Stephan, Berg, Leonard H., Pol, W. Ludo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged CD46 antigen CD55 CD55 Antigens - genetics CD59 antigen CD59 Antigens - genetics Complement activation Complement component C5 Complement system DAF Disease Progression Female Gene polymorphism genetics Genotype Genotype & phenotype Humans Inflammation Male Medical research Membrane Cofactor Protein - genetics Middle Aged multifocal motor neuropathy Patients Polyneuropathies - genetics Polyneuropathies - immunology Polyneuropathies - physiopathology Progressive motor neuropathy Promoter Regions, Genetic Sequence Deletion
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