COL10A1 expression distinguishes a subset of cancer-associated fibroblasts present in the stroma of high-risk basal cell carcinoma

Basal cell carcinoma (BCC) is the most frequently diagnosed skin cancer and the most common malignancy in humans. Different morphological subtypes of BCC are associated with a low or high risk of recurrence and aggressiveness, but the underlying biology of how the individual subtypes arise remains l...

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Veröffentlicht in:	British journal of dermatology (1951) 2024-10, Vol.191 (5), p.775-790
Hauptverfasser:	Esposito, Mauro, Yerly, Laura, Shukla, Prachi, Hermes, Victoria, Sella, Federica, Balazs, Zsolt, Lattmann, Evelyn, Tastanova, Aizhan, Turko, Patrick, Lang, Ramon, Kolm, Isabel, Staeger, Ramon, Kuonen, François, Krauthammer, Michael, Hafner, Juerg, Levesque, Mitchell P, Restivo, Gaetana
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers, Tumor - analysis Cancer-Associated Fibroblasts - metabolism Cancer-Associated Fibroblasts - pathology Carcinoma, Basal Cell - genetics Carcinoma, Basal Cell - metabolism Carcinoma, Basal Cell - pathology Female Humans Laser Capture Microdissection Male Middle Aged RNA-Seq Single-Cell Analysis Skin - pathology Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Tumor Microenvironment
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