De Novo Synthesis and Structural Elucidation of CDR-H3 Loop Mimics

The binding affinity of antibodies to specific antigens stems from a remarkably broad repertoire of hypervariable loops known as complementarity-determining regions (CDRs). While recognizing the pivotal role of the heavy-chain 3 CDRs (CDR-H3s) in maximizing antibody–antigen affinity and specificity,...

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Veröffentlicht in:	ACS chemical biology 2024-07, Vol.19 (7), p.1583-1592
Hauptverfasser:	Zhao, Guangkuan, Richaud, Alexis D., Williamson, R. Thomas, Feig, Michael, Roche, Stéphane P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Complementarity Determining Regions - chemistry Humans Immunoglobulin Heavy Chains - chemistry Models, Molecular
Online-Zugang:	Volltext
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