Cellular Senescence in Acute Liver Injury: What Happens to the Young Liver?

Cellular Senescence in Acute Liver Injury: What Happens to the Young Liver?

Cellular senescence, characterized by irreversible cell cycle arrest, not only exists in age-related physiological states, but has been found to exist in various diseases. It plays a crucial role in both physiological and pathological processes and has become a trending topic in global research in r...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Aging and disease 2024-06
Hauptverfasser: He, Keting, Zhou, Diwenxin, Pu, Zhangya, Chen, Shangci, Shen, Yangfan, Zhao, Shuai, Qian, Xiaohan, Hu, Qingqing, Wu, Xiaoxin, Xie, Zhongyang, Xu, Xiaowei
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title Aging and disease
container_volume
creator He, Keting
Zhou, Diwenxin
Pu, Zhangya
Chen, Shangci
Shen, Yangfan
Zhao, Shuai
Qian, Xiaohan
Hu, Qingqing
Wu, Xiaoxin
Xie, Zhongyang
Xu, Xiaowei
description Cellular senescence, characterized by irreversible cell cycle arrest, not only exists in age-related physiological states, but has been found to exist in various diseases. It plays a crucial role in both physiological and pathological processes and has become a trending topic in global research in recent years. Acute liver injury (ALI) has a high incidence worldwide, and recent studies have shown that hepatic senescence can be induced following ALI. Therefore, we reviewed the significance of cellular senescence in ALI. To minimize the potential confounding effects of aging on cellular senescence and ALI outcomes, we selected studies involving young individuals to identify the characteristics of senescent cells, the value of cellular senescence in liver repair, its regulation mechanisms in ALI, its potential as a biomarker for ALI, the prospect of treatment, and future research directions.
doi_str_mv 10.14336/AD.2024.0586
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3071517174</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3071517174</sourcerecordid><originalsourceid>FETCH-LOGICAL-c218t-71818038790835fa018183b6fd84987c0bebc897a94083bd180361d8047523be3</originalsourceid><addsrcrecordid>eNpNkEFLw0AQRhdRbKk9epU9eknd3UmyGy8SWrXFggcV8bRskolNSZO4mwj99yZWxbnMfPD4GB4h55zNuA8QXsWLmWDCn7FAhUdkLHggvEAE7PjfPSJT57asH4gERHBKRqAiDsyHMXmYY1l2pbH0CSt0KVYp0qKicdq1SNfFJ1q6qrad3V_T141p6dI0DVaOtjVtN0jf6q56P3A3Z-QkN6XD6c-ekJe72-f50ls_3q_m8dpLBVetJ7niioGSEVMQ5IYNGZIwz5QfKZmyBJNURdJEfg8k2QCHPFPMl4GABGFCLg-9ja0_OnSt3hX952VpKqw7p4FJHnDJpd-j3gFNbe2cxVw3ttgZu9ec6W-FOl7oQaEeFPb8xU91l-ww-6N_hcEXSyJoNA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3071517174</pqid></control><display><type>article</type><title>Cellular Senescence in Acute Liver Injury: What Happens to the Young Liver?</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>He, Keting ; Zhou, Diwenxin ; Pu, Zhangya ; Chen, Shangci ; Shen, Yangfan ; Zhao, Shuai ; Qian, Xiaohan ; Hu, Qingqing ; Wu, Xiaoxin ; Xie, Zhongyang ; Xu, Xiaowei</creator><creatorcontrib>He, Keting ; Zhou, Diwenxin ; Pu, Zhangya ; Chen, Shangci ; Shen, Yangfan ; Zhao, Shuai ; Qian, Xiaohan ; Hu, Qingqing ; Wu, Xiaoxin ; Xie, Zhongyang ; Xu, Xiaowei</creatorcontrib><description>Cellular senescence, characterized by irreversible cell cycle arrest, not only exists in age-related physiological states, but has been found to exist in various diseases. It plays a crucial role in both physiological and pathological processes and has become a trending topic in global research in recent years. Acute liver injury (ALI) has a high incidence worldwide, and recent studies have shown that hepatic senescence can be induced following ALI. Therefore, we reviewed the significance of cellular senescence in ALI. To minimize the potential confounding effects of aging on cellular senescence and ALI outcomes, we selected studies involving young individuals to identify the characteristics of senescent cells, the value of cellular senescence in liver repair, its regulation mechanisms in ALI, its potential as a biomarker for ALI, the prospect of treatment, and future research directions.</description><identifier>ISSN: 2152-5250</identifier><identifier>EISSN: 2152-5250</identifier><identifier>DOI: 10.14336/AD.2024.0586</identifier><identifier>PMID: 38913043</identifier><language>eng</language><publisher>United States</publisher><ispartof>Aging and disease, 2024-06</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c218t-71818038790835fa018183b6fd84987c0bebc897a94083bd180361d8047523be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38913043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Keting</creatorcontrib><creatorcontrib>Zhou, Diwenxin</creatorcontrib><creatorcontrib>Pu, Zhangya</creatorcontrib><creatorcontrib>Chen, Shangci</creatorcontrib><creatorcontrib>Shen, Yangfan</creatorcontrib><creatorcontrib>Zhao, Shuai</creatorcontrib><creatorcontrib>Qian, Xiaohan</creatorcontrib><creatorcontrib>Hu, Qingqing</creatorcontrib><creatorcontrib>Wu, Xiaoxin</creatorcontrib><creatorcontrib>Xie, Zhongyang</creatorcontrib><creatorcontrib>Xu, Xiaowei</creatorcontrib><title>Cellular Senescence in Acute Liver Injury: What Happens to the Young Liver?</title><title>Aging and disease</title><addtitle>Aging Dis</addtitle><description>Cellular senescence, characterized by irreversible cell cycle arrest, not only exists in age-related physiological states, but has been found to exist in various diseases. It plays a crucial role in both physiological and pathological processes and has become a trending topic in global research in recent years. Acute liver injury (ALI) has a high incidence worldwide, and recent studies have shown that hepatic senescence can be induced following ALI. Therefore, we reviewed the significance of cellular senescence in ALI. To minimize the potential confounding effects of aging on cellular senescence and ALI outcomes, we selected studies involving young individuals to identify the characteristics of senescent cells, the value of cellular senescence in liver repair, its regulation mechanisms in ALI, its potential as a biomarker for ALI, the prospect of treatment, and future research directions.</description><issn>2152-5250</issn><issn>2152-5250</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpNkEFLw0AQRhdRbKk9epU9eknd3UmyGy8SWrXFggcV8bRskolNSZO4mwj99yZWxbnMfPD4GB4h55zNuA8QXsWLmWDCn7FAhUdkLHggvEAE7PjfPSJT57asH4gERHBKRqAiDsyHMXmYY1l2pbH0CSt0KVYp0qKicdq1SNfFJ1q6qrad3V_T141p6dI0DVaOtjVtN0jf6q56P3A3Z-QkN6XD6c-ekJe72-f50ls_3q_m8dpLBVetJ7niioGSEVMQ5IYNGZIwz5QfKZmyBJNURdJEfg8k2QCHPFPMl4GABGFCLg-9ja0_OnSt3hX952VpKqw7p4FJHnDJpd-j3gFNbe2cxVw3ttgZu9ec6W-FOl7oQaEeFPb8xU91l-ww-6N_hcEXSyJoNA</recordid><startdate>20240619</startdate><enddate>20240619</enddate><creator>He, Keting</creator><creator>Zhou, Diwenxin</creator><creator>Pu, Zhangya</creator><creator>Chen, Shangci</creator><creator>Shen, Yangfan</creator><creator>Zhao, Shuai</creator><creator>Qian, Xiaohan</creator><creator>Hu, Qingqing</creator><creator>Wu, Xiaoxin</creator><creator>Xie, Zhongyang</creator><creator>Xu, Xiaowei</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240619</creationdate><title>Cellular Senescence in Acute Liver Injury: What Happens to the Young Liver?</title><author>He, Keting ; Zhou, Diwenxin ; Pu, Zhangya ; Chen, Shangci ; Shen, Yangfan ; Zhao, Shuai ; Qian, Xiaohan ; Hu, Qingqing ; Wu, Xiaoxin ; Xie, Zhongyang ; Xu, Xiaowei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c218t-71818038790835fa018183b6fd84987c0bebc897a94083bd180361d8047523be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Keting</creatorcontrib><creatorcontrib>Zhou, Diwenxin</creatorcontrib><creatorcontrib>Pu, Zhangya</creatorcontrib><creatorcontrib>Chen, Shangci</creatorcontrib><creatorcontrib>Shen, Yangfan</creatorcontrib><creatorcontrib>Zhao, Shuai</creatorcontrib><creatorcontrib>Qian, Xiaohan</creatorcontrib><creatorcontrib>Hu, Qingqing</creatorcontrib><creatorcontrib>Wu, Xiaoxin</creatorcontrib><creatorcontrib>Xie, Zhongyang</creatorcontrib><creatorcontrib>Xu, Xiaowei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Aging and disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Keting</au><au>Zhou, Diwenxin</au><au>Pu, Zhangya</au><au>Chen, Shangci</au><au>Shen, Yangfan</au><au>Zhao, Shuai</au><au>Qian, Xiaohan</au><au>Hu, Qingqing</au><au>Wu, Xiaoxin</au><au>Xie, Zhongyang</au><au>Xu, Xiaowei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular Senescence in Acute Liver Injury: What Happens to the Young Liver?</atitle><jtitle>Aging and disease</jtitle><addtitle>Aging Dis</addtitle><date>2024-06-19</date><risdate>2024</risdate><issn>2152-5250</issn><eissn>2152-5250</eissn><abstract>Cellular senescence, characterized by irreversible cell cycle arrest, not only exists in age-related physiological states, but has been found to exist in various diseases. It plays a crucial role in both physiological and pathological processes and has become a trending topic in global research in recent years. Acute liver injury (ALI) has a high incidence worldwide, and recent studies have shown that hepatic senescence can be induced following ALI. Therefore, we reviewed the significance of cellular senescence in ALI. To minimize the potential confounding effects of aging on cellular senescence and ALI outcomes, we selected studies involving young individuals to identify the characteristics of senescent cells, the value of cellular senescence in liver repair, its regulation mechanisms in ALI, its potential as a biomarker for ALI, the prospect of treatment, and future research directions.</abstract><cop>United States</cop><pmid>38913043</pmid><doi>10.14336/AD.2024.0586</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2152-5250
ispartof Aging and disease, 2024-06
issn 2152-5250
2152-5250
language eng
recordid cdi_proquest_miscellaneous_3071517174
source DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
title Cellular Senescence in Acute Liver Injury: What Happens to the Young Liver?
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T21%3A17%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cellular%20Senescence%20in%20Acute%20Liver%20Injury:%20What%20Happens%20to%20the%20Young%20Liver?&rft.jtitle=Aging%20and%20disease&rft.au=He,%20Keting&rft.date=2024-06-19&rft.issn=2152-5250&rft.eissn=2152-5250&rft_id=info:doi/10.14336/AD.2024.0586&rft_dat=%3Cproquest_cross%3E3071517174%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3071517174&rft_id=info:pmid/38913043&rfr_iscdi=true