The role of DNA damage response in human embryonic stem cells exposed to atmospheric oxygen tension: Implications for embryo development and differentiation

Previous retrospective cohort studies have found that, compared with oxygen tension in the uterus and fallopian tubes (2 %-8 %), exposure of pre-implantation embryos to atmospheric oxygen tension (AtmO2, 20 %) during assisted reproductive technology(ART) can affect embryo quality, pregnancy outcomes...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2024-09, Vol.128, p.108648, Article 108648
Hauptverfasser:	Zhou, Yuanyuan, Ye, Fenglei, Zhang, Linyun, Kang, Quanmin, Luo, Yujia, Jiang, Nan, Lou, Lijun, Mao, Yuchan, Wang, Liya, Jin, Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Assisted reproductive technology Atmospheric oxygen tension Autophagy - drug effects Cell Differentiation - drug effects Cell Line Cell Survival - drug effects DNA Damage DNA damage response DNA Repair Embryo development Embryonic Development - drug effects Human embryonic stem cells Human Embryonic Stem Cells - drug effects Human Embryonic Stem Cells - metabolism Humans Oxidative stress Oxidative Stress - drug effects Oxygen - toxicity
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