Development of Hsp90 inhibitor to regulate cytokine storms in excessive delayed- and acute inflammation

•Excessive cytokine storms can be controlled through Hsp90.•Be01 has anti-inflammatory effects by decreasing surface molecules and cytokines in DCs and macrophages.•Inhibiting Hsp90 via Be01 highly decreased inflammation in vivo DTH and ALI models. The surplus cytokines remaining after use in the ea...

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Veröffentlicht in:	International immunopharmacology 2024-08, Vol.137, p.112470, Article 112470
Hauptverfasser:	Sim, Hyun Bo, Sang Son, Jun, Gupta, Sunil K., Jeong, Seung-Hyun, Choi, Yu-Jeong, Han, Ji Yeon, Ramos, Sonny C., Kim, Hyeongyeong, Park, Dae-Han, Yoo, Ho Jin, Yoo, Young Joo, Chang, Dong-Jo, Mun, Seul-Ki, Seo, Young Ho, Kim, Jong-Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury (ALI) Acute Lung Injury - drug therapy Acute Lung Injury - immunology Animals Anti-inflammatory Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use B7-2 Antigen - metabolism Cells, Cultured Cytokine Release Syndrome - drug therapy Cytokine Release Syndrome - immunology Cytokines - metabolism Delayed-Type Hypersensitivity (DTH) Dendritic Cells - drug effects Dendritic Cells - immunology Disease Models, Animal Female Hsp90 HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - metabolism Hypersensitivity, Delayed - drug therapy Hypersensitivity, Delayed - immunology Inflammation - drug therapy Inflammation - immunology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Mice Mice, Inbred C57BL Spleen - drug effects Spleen - immunology Th1 Cells - drug effects Th1 Cells - immunology
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