Procoagulant phenotype of virus-infected pericytes is associated with portal thrombosis and intrapulmonary vascular dilations in fatal COVID-19

The underlying mechanisms and clinical impact of portal microthrombosis in severe COVID-19 are unknown. Intrapulmonary vascular dilation (IPVD)-related hypoxia has been described in severe liver diseases. We hypothesised that portal microthrombosis is associated with IPVD and fatal respiratory failu...

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Veröffentlicht in:	Journal of hepatology 2024-11, Vol.81 (5), p.872-885
Hauptverfasser:	Cadamuro, Massimiliano, Lasagni, Alberto, Radu, Claudia Maria, Calistri, Arianna, Pilan, Matteo, Valle, Clarissa, Bonaffini, Pietro Andrea, Vitiello, Adriana, Toffanin, Serena, Venturin, Camilla, Friòn-Herrera, Yahima, Sironi, Sandro, Alessio, Maria Grazia, Previtali, Giulia, Seghezzi, Michela, Gianatti, Andrea, Strazzabosco, Mario, Strain, Alastair J., Campello, Elena, Spiezia, Luca, Palù, Giorgio, Frigo, Anna Chiara, Tosoni, Antonella, Nebuloni, Manuela, Parolin, Cristina, Sonzogni, Aurelio, Simioni, Paolo, Fabris, Luca
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Betacoronavirus COVID-19 - complications COVID-19 - mortality Endothelial Cells - metabolism Endothelial Cells - pathology Endothelial Cells - virology Female Humans Hypoxia Lung - pathology Male Middle Aged Pericytes - metabolism Pericytes - pathology Pericytes - virology Phenotype Pneumonia, Viral - complications Pneumonia, Viral - mortality Pneumonia, Viral - pathology Pneumonia, Viral - virology portal fibrosis Portal Vein - pathology SARS-CoV-2 Thromboplastin - analysis Thromboplastin - metabolism tissue factor vascular liver disease Venous Thrombosis - etiology Venous Thrombosis - pathology Venous Thrombosis - virology von Willebrand factor
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