Myocardial performance imaging for the early identification of cardiac dysfunction in neonates with sepsis
Purpose The assessment of cardiac performance in septic new-borns is crucial for detecting hemodynamic instability and predicting outcome. The aim of the study is to assess myocardial performance in neonates with sepsis for the early identification of cardiac dysfunction. Patients and methods A case...
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| Veröffentlicht in: | The international journal of cardiovascular imaging 2024-07, Vol.40 (7), p.1435-1444 |
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| creator | Sumbaraju, Sudheshna Lalitha Nayak, Krishnananda Prabhu, Sridevi Nayak, Vidya Prabhu, K Prathiksha Lewis, Leslie Edward |
| description | Purpose
The assessment of cardiac performance in septic new-borns is crucial for detecting hemodynamic instability and predicting outcome. The aim of the study is to assess myocardial performance in neonates with sepsis for the early identification of cardiac dysfunction.
Patients and methods
A case control study was carried out from September 2022 to May 2023 at the Neonatal Intensive care unit, Kasturba Medical College, Manipal. A total of 68 neonates were included in the study, with 33 females and 35 males. The study population was further subdivided into 3 groups namely preterm septic neonates (
n
= 21), term septic neonates (
n
= 10) and non-septic healthy controls (
n
= 37). The cardiac structure and function were assessed using conventional method, Tissue Doppler imaging (Sm) and speckle tracking echocardiography (GLS). The study was approved by the Institutional Ethics Committee at Kasturba Medical College, Manipal (approval number IEC: 90/2022). The CTRI registration number for the study is CTRI/2022/09/045437 and was approved on September 12, 2022. Prior to the neonate’s enrolment, informed consent was obtained from their mothers or legal guardians.
Results
Out of the total 68 neonates, 31 were cases and 37 were controls which included 33 females and 35 males. LV systolic function was not statistically significant between cases and controls. E/A ratio of the mitral valve was significantly lower in septic newborns than in healthy neonates. (1.01 ± 0.35 vs 1.18 ± 0.31, p |
| doi_str_mv | 10.1007/s10554-024-03120-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3071281828</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3082427310</sourcerecordid><originalsourceid>FETCH-LOGICAL-c300t-4f8b2d67e6a1650ae6493989be27a1cb65ba4d36c663a9f74fdc0815454060d83</originalsourceid><addsrcrecordid>eNp9kU9vFSEUxYnR2Nr2C7hoSNy4Gb38GWCWTdOqSY0bXROGubzyMo95wkya108v7dRqXLggwOV3Djf3EPKWwQcGoD8WBm0rG-B1CcahuX9BjpnRbWPq9eVf5yPyppQtANOi616TI2E60KaVx2T79TB5l4foRrrHHKa8c8kjjTu3iWlDa4HOt0jR5fFA44BpjiF6N8cp0SnQVevpcChhSf6xHBNNOCU3Y6F3cb6lBfclllPyKrix4NnTfkJ-XF99v_zc3Hz79OXy4qbxAmBuZDA9H5RG5ZhqwaGSnehM1yPXjvletb2Tg1BeKeG6oGUYPBjWylaCgsGIE_J-9d3n6eeCZba7WDyOo6tdLcUK0IwbZvgD-u4fdDstOdXuKmW45FowqBRfKZ-nUjIGu891PvlgGdiHJOyahK1J2Mck7H0VnT9ZL_0Oh2fJ79FXQKxAqU9pg_nP3_-x_QXEspUH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3082427310</pqid></control><display><type>article</type><title>Myocardial performance imaging for the early identification of cardiac dysfunction in neonates with sepsis</title><source>Springer Nature - Complete Springer Journals</source><creator>Sumbaraju, Sudheshna Lalitha ; Nayak, Krishnananda ; Prabhu, Sridevi ; Nayak, Vidya ; Prabhu, K Prathiksha ; Lewis, Leslie Edward</creator><creatorcontrib>Sumbaraju, Sudheshna Lalitha ; Nayak, Krishnananda ; Prabhu, Sridevi ; Nayak, Vidya ; Prabhu, K Prathiksha ; Lewis, Leslie Edward</creatorcontrib><description>Purpose
The assessment of cardiac performance in septic new-borns is crucial for detecting hemodynamic instability and predicting outcome. The aim of the study is to assess myocardial performance in neonates with sepsis for the early identification of cardiac dysfunction.
Patients and methods
A case control study was carried out from September 2022 to May 2023 at the Neonatal Intensive care unit, Kasturba Medical College, Manipal. A total of 68 neonates were included in the study, with 33 females and 35 males. The study population was further subdivided into 3 groups namely preterm septic neonates (
n
= 21), term septic neonates (
n
= 10) and non-septic healthy controls (
n
= 37). The cardiac structure and function were assessed using conventional method, Tissue Doppler imaging (Sm) and speckle tracking echocardiography (GLS). The study was approved by the Institutional Ethics Committee at Kasturba Medical College, Manipal (approval number IEC: 90/2022). The CTRI registration number for the study is CTRI/2022/09/045437 and was approved on September 12, 2022. Prior to the neonate’s enrolment, informed consent was obtained from their mothers or legal guardians.
Results
Out of the total 68 neonates, 31 were cases and 37 were controls which included 33 females and 35 males. LV systolic function was not statistically significant between cases and controls. E/A ratio of the mitral valve was significantly lower in septic newborns than in healthy neonates. (1.01 ± 0.35 vs 1.18 ± 0.31, p < 0.05) preterm neonates showed significantly lower Lateral E’ and RV E’ velocities than term neonates. TAPSE was significantly lower in septic preterm neonates. (8.61 ± 1.28 vs. 10.7 ± 2.11,
p
< 0.05) No significant difference was noted in the Myocardial Performance Index between septic neonates and healthy neonates. LV Global Longitudinal Strain was slightly lower in preterm septic neonates than in term neonates with sepsis.
Conclusion
Septic newborns are associated with LV diastolic dysfunction, RV systolic dysfunction and substantially higher pulmonary systolic pressures.</description><identifier>ISSN: 1875-8312</identifier><identifier>ISSN: 1569-5794</identifier><identifier>EISSN: 1875-8312</identifier><identifier>EISSN: 1573-0743</identifier><identifier>DOI: 10.1007/s10554-024-03120-z</identifier><identifier>PMID: 38907854</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Cardiac Imaging ; Cardiology ; Doppler effect ; Echocardiography ; Females ; Hemodynamics ; Imaging ; Informed consent ; Males ; Medical imaging ; Medicine ; Medicine & Public Health ; Mitral valve ; Neonates ; Original Paper ; Performance indices ; Performance prediction ; Population studies ; Predictive control ; Radiology ; Sepsis ; Statistical analysis ; Structure-function relationships</subject><ispartof>The international journal of cardiovascular imaging, 2024-07, Vol.40 (7), p.1435-1444</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-4f8b2d67e6a1650ae6493989be27a1cb65ba4d36c663a9f74fdc0815454060d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10554-024-03120-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10554-024-03120-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38907854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sumbaraju, Sudheshna Lalitha</creatorcontrib><creatorcontrib>Nayak, Krishnananda</creatorcontrib><creatorcontrib>Prabhu, Sridevi</creatorcontrib><creatorcontrib>Nayak, Vidya</creatorcontrib><creatorcontrib>Prabhu, K Prathiksha</creatorcontrib><creatorcontrib>Lewis, Leslie Edward</creatorcontrib><title>Myocardial performance imaging for the early identification of cardiac dysfunction in neonates with sepsis</title><title>The international journal of cardiovascular imaging</title><addtitle>Int J Cardiovasc Imaging</addtitle><addtitle>Int J Cardiovasc Imaging</addtitle><description>Purpose
The assessment of cardiac performance in septic new-borns is crucial for detecting hemodynamic instability and predicting outcome. The aim of the study is to assess myocardial performance in neonates with sepsis for the early identification of cardiac dysfunction.
Patients and methods
A case control study was carried out from September 2022 to May 2023 at the Neonatal Intensive care unit, Kasturba Medical College, Manipal. A total of 68 neonates were included in the study, with 33 females and 35 males. The study population was further subdivided into 3 groups namely preterm septic neonates (
n
= 21), term septic neonates (
n
= 10) and non-septic healthy controls (
n
= 37). The cardiac structure and function were assessed using conventional method, Tissue Doppler imaging (Sm) and speckle tracking echocardiography (GLS). The study was approved by the Institutional Ethics Committee at Kasturba Medical College, Manipal (approval number IEC: 90/2022). The CTRI registration number for the study is CTRI/2022/09/045437 and was approved on September 12, 2022. Prior to the neonate’s enrolment, informed consent was obtained from their mothers or legal guardians.
Results
Out of the total 68 neonates, 31 were cases and 37 were controls which included 33 females and 35 males. LV systolic function was not statistically significant between cases and controls. E/A ratio of the mitral valve was significantly lower in septic newborns than in healthy neonates. (1.01 ± 0.35 vs 1.18 ± 0.31, p < 0.05) preterm neonates showed significantly lower Lateral E’ and RV E’ velocities than term neonates. TAPSE was significantly lower in septic preterm neonates. (8.61 ± 1.28 vs. 10.7 ± 2.11,
p
< 0.05) No significant difference was noted in the Myocardial Performance Index between septic neonates and healthy neonates. LV Global Longitudinal Strain was slightly lower in preterm septic neonates than in term neonates with sepsis.
Conclusion
Septic newborns are associated with LV diastolic dysfunction, RV systolic dysfunction and substantially higher pulmonary systolic pressures.</description><subject>Cardiac Imaging</subject><subject>Cardiology</subject><subject>Doppler effect</subject><subject>Echocardiography</subject><subject>Females</subject><subject>Hemodynamics</subject><subject>Imaging</subject><subject>Informed consent</subject><subject>Males</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mitral valve</subject><subject>Neonates</subject><subject>Original Paper</subject><subject>Performance indices</subject><subject>Performance prediction</subject><subject>Population studies</subject><subject>Predictive control</subject><subject>Radiology</subject><subject>Sepsis</subject><subject>Statistical analysis</subject><subject>Structure-function relationships</subject><issn>1875-8312</issn><issn>1569-5794</issn><issn>1875-8312</issn><issn>1573-0743</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kU9vFSEUxYnR2Nr2C7hoSNy4Gb38GWCWTdOqSY0bXROGubzyMo95wkya108v7dRqXLggwOV3Djf3EPKWwQcGoD8WBm0rG-B1CcahuX9BjpnRbWPq9eVf5yPyppQtANOi616TI2E60KaVx2T79TB5l4foRrrHHKa8c8kjjTu3iWlDa4HOt0jR5fFA44BpjiF6N8cp0SnQVevpcChhSf6xHBNNOCU3Y6F3cb6lBfclllPyKrix4NnTfkJ-XF99v_zc3Hz79OXy4qbxAmBuZDA9H5RG5ZhqwaGSnehM1yPXjvletb2Tg1BeKeG6oGUYPBjWylaCgsGIE_J-9d3n6eeCZba7WDyOo6tdLcUK0IwbZvgD-u4fdDstOdXuKmW45FowqBRfKZ-nUjIGu891PvlgGdiHJOyahK1J2Mck7H0VnT9ZL_0Oh2fJ79FXQKxAqU9pg_nP3_-x_QXEspUH</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Sumbaraju, Sudheshna Lalitha</creator><creator>Nayak, Krishnananda</creator><creator>Prabhu, Sridevi</creator><creator>Nayak, Vidya</creator><creator>Prabhu, K Prathiksha</creator><creator>Lewis, Leslie Edward</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20240701</creationdate><title>Myocardial performance imaging for the early identification of cardiac dysfunction in neonates with sepsis</title><author>Sumbaraju, Sudheshna Lalitha ; Nayak, Krishnananda ; Prabhu, Sridevi ; Nayak, Vidya ; Prabhu, K Prathiksha ; Lewis, Leslie Edward</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-4f8b2d67e6a1650ae6493989be27a1cb65ba4d36c663a9f74fdc0815454060d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cardiac Imaging</topic><topic>Cardiology</topic><topic>Doppler effect</topic><topic>Echocardiography</topic><topic>Females</topic><topic>Hemodynamics</topic><topic>Imaging</topic><topic>Informed consent</topic><topic>Males</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mitral valve</topic><topic>Neonates</topic><topic>Original Paper</topic><topic>Performance indices</topic><topic>Performance prediction</topic><topic>Population studies</topic><topic>Predictive control</topic><topic>Radiology</topic><topic>Sepsis</topic><topic>Statistical analysis</topic><topic>Structure-function relationships</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sumbaraju, Sudheshna Lalitha</creatorcontrib><creatorcontrib>Nayak, Krishnananda</creatorcontrib><creatorcontrib>Prabhu, Sridevi</creatorcontrib><creatorcontrib>Nayak, Vidya</creatorcontrib><creatorcontrib>Prabhu, K Prathiksha</creatorcontrib><creatorcontrib>Lewis, Leslie Edward</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of cardiovascular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sumbaraju, Sudheshna Lalitha</au><au>Nayak, Krishnananda</au><au>Prabhu, Sridevi</au><au>Nayak, Vidya</au><au>Prabhu, K Prathiksha</au><au>Lewis, Leslie Edward</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial performance imaging for the early identification of cardiac dysfunction in neonates with sepsis</atitle><jtitle>The international journal of cardiovascular imaging</jtitle><stitle>Int J Cardiovasc Imaging</stitle><addtitle>Int J Cardiovasc Imaging</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>40</volume><issue>7</issue><spage>1435</spage><epage>1444</epage><pages>1435-1444</pages><issn>1875-8312</issn><issn>1569-5794</issn><eissn>1875-8312</eissn><eissn>1573-0743</eissn><abstract>Purpose
The assessment of cardiac performance in septic new-borns is crucial for detecting hemodynamic instability and predicting outcome. The aim of the study is to assess myocardial performance in neonates with sepsis for the early identification of cardiac dysfunction.
Patients and methods
A case control study was carried out from September 2022 to May 2023 at the Neonatal Intensive care unit, Kasturba Medical College, Manipal. A total of 68 neonates were included in the study, with 33 females and 35 males. The study population was further subdivided into 3 groups namely preterm septic neonates (
n
= 21), term septic neonates (
n
= 10) and non-septic healthy controls (
n
= 37). The cardiac structure and function were assessed using conventional method, Tissue Doppler imaging (Sm) and speckle tracking echocardiography (GLS). The study was approved by the Institutional Ethics Committee at Kasturba Medical College, Manipal (approval number IEC: 90/2022). The CTRI registration number for the study is CTRI/2022/09/045437 and was approved on September 12, 2022. Prior to the neonate’s enrolment, informed consent was obtained from their mothers or legal guardians.
Results
Out of the total 68 neonates, 31 were cases and 37 were controls which included 33 females and 35 males. LV systolic function was not statistically significant between cases and controls. E/A ratio of the mitral valve was significantly lower in septic newborns than in healthy neonates. (1.01 ± 0.35 vs 1.18 ± 0.31, p < 0.05) preterm neonates showed significantly lower Lateral E’ and RV E’ velocities than term neonates. TAPSE was significantly lower in septic preterm neonates. (8.61 ± 1.28 vs. 10.7 ± 2.11,
p
< 0.05) No significant difference was noted in the Myocardial Performance Index between septic neonates and healthy neonates. LV Global Longitudinal Strain was slightly lower in preterm septic neonates than in term neonates with sepsis.
Conclusion
Septic newborns are associated with LV diastolic dysfunction, RV systolic dysfunction and substantially higher pulmonary systolic pressures.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>38907854</pmid><doi>10.1007/s10554-024-03120-z</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1875-8312 |
| ispartof | The international journal of cardiovascular imaging, 2024-07, Vol.40 (7), p.1435-1444 |
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| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Cardiac Imaging Cardiology Doppler effect Echocardiography Females Hemodynamics Imaging Informed consent Males Medical imaging Medicine Medicine & Public Health Mitral valve Neonates Original Paper Performance indices Performance prediction Population studies Predictive control Radiology Sepsis Statistical analysis Structure-function relationships |
| title | Myocardial performance imaging for the early identification of cardiac dysfunction in neonates with sepsis |
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