Chronic PM2.5 exposure disrupts intestinal barrier integrity via microbial dysbiosis-triggered TLR2/5-MyD88-NLRP3 inflammasome activation

PM2.5, a known public health risk, is increasingly linked to intestinal disorders, however, the mechanisms of its impact are not fully understood. This study aimed to explore the impact of chronic PM2.5 exposure on intestinal barrier integrity and to uncover the underlying molecular mechanisms. C57B...

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Veröffentlicht in:	Environmental research 2024-10, Vol.258, p.119415, Article 119415
Hauptverfasser:	Ran, Zihan, Yang, Jingcheng, Liu, Liang, Wu, Shaobo, An, YanPeng, Hou, Wanwan, Cheng, Tianyuan, Zhang, Youyi, Zhang, Yiqing, Huang, Yechao, Zhang, Qianyue, Wan, Jiaping, Li, Xuemei, Xing, Baoling, Ye, Yuchen, Xu, Penghao, Chen, Zhenghu, Zhao, Jinzhuo, Li, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Inflammasome activation Intestinal barrier integrity Metabolic perturbations Microbial dysbiosis PM2.5
Online-Zugang:	Volltext
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