Design, synthesis and biological evaluation of novel naphthoquinothiazole derivatives as potent antitumor agents through inhibiting STAT3

[Display omitted] •SZ6 inhibits STAT3 phosphorylation and also induces ROS production.•SZ6 inhibits STAT3 phosphorylation by directly binding to STAT3;•SZ6 shows potent anti-tumor effects in colorectal cancer models. The signal transducer and activator of transcription 3 (STAT3) has been established...

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Veröffentlicht in:	Bioorganic chemistry 2024-09, Vol.150, p.107565, Article 107565
Hauptverfasser:	Fan, Dongmei, Liu, Pingxian, Li, Zhilin, He, Xinlian, Zhang, Lidan, Jiang, Weiqing, Ang, Wei, Yang, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Benzofurans Cell Movement - drug effects Cell Proliferation - drug effects colorectal cancer (CRC) Dose-Response Relationship, Drug Drug Design Drug Screening Assays, Antitumor Humans Mice Mice, Inbred BALB C Mice, Nude Molecular Structure Naphthoquinones - chemical synthesis Naphthoquinones - chemistry Naphthoquinones - pharmacology Naphthoquinothiazole derivatives ROS production STAT3 inhibitors STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism Structure-Activity Relationship Thiazoles - chemical synthesis Thiazoles - chemistry Thiazoles - pharmacology
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