CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia via CPT1A-mediated fatty acid oxidation

Multiple theories have been proposed to explain the pathogenesis of early-onset preeclampsia (EOPE), and angiogenic dysfunction is an important part of this pathogenesis. Carnitine palmitoyltransferase (CPT1A) is a key rate-limiting enzyme in the metabolic process of fatty acid oxidation (FAO). FAO...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2024-08, Vol.102 (8), p.1037-1049
Hauptverfasser:	Wu, Yanying, Huang, Jingrui, Liu, Lijuan, Zhang, Xiaowen, Zhang, Weishe, Li, Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Angiogenesis Biomedical and Life Sciences Biomedicine Carnitine O-Palmitoyltransferase - genetics Carnitine O-Palmitoyltransferase - metabolism Carnitine palmitoyltransferase Cell Proliferation Endothelial cells Fatty acids Fatty Acids - metabolism Female Germination Human Genetics Human Umbilical Vein Endothelial Cells - metabolism Humans Internal Medicine MicroRNAs - genetics MicroRNAs - metabolism Molecular Medicine Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Original Article Oxidation Oxidation-Reduction Palmitoyltransferase Pathogenesis Placenta - metabolism Pre-eclampsia Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Preeclampsia Pregnancy RNA, Circular - genetics RNA, Circular - metabolism
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