Risk factors affecting delay of initiating adjuvant chemotherapy for stage III colorectal cancer
Purpose Delay in initiating adjuvant chemotherapy (AC) after curative resection of colorectal cancer (CRC) has been reported to lead to poor prognosis, but few studies have looked at associated factors. This study aimed to identify risk factors for delay in initiating AC. Methods Data from 200 conse...
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| Veröffentlicht in: | International journal of clinical oncology 2024-09, Vol.29 (9), p.1293-1301 |
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| container_title | International journal of clinical oncology |
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| creator | Maeda, Shingo Ouchi, Akira Komori, Koji Kinoshita, Takashi Sato, Yusuke Muro, Kei Taniguchi, Hiroya Masuishi, Toshiki Ito, Seiji Abe, Tetsuya Shimizu, Yasuhiro |
| description | Purpose
Delay in initiating adjuvant chemotherapy (AC) after curative resection of colorectal cancer (CRC) has been reported to lead to poor prognosis, but few studies have looked at associated factors. This study aimed to identify risk factors for delay in initiating AC.
Methods
Data from 200 consecutive patients who underwent curative resection and AC for stage III CRC between 2013 and 2018 were retrospectively collected and analyzed.
Results
AC was initiated more than 8 weeks after surgery in 12.5% of patients (the delay group). Compared to those with no delay (the non-delay group), patients in the delay group had significantly higher rates of synchronous double cancers (2.3% vs. 16.0%,
p
= 0.001), preoperative bowel obstruction (10.3% vs. 32.0%,
p
= 0.003), laparotomy (56.0% vs. 80.0%,
p
= 0.02), concomitant resection (2.9% vs. 24.0%,
p
|
| doi_str_mv | 10.1007/s10147-024-02567-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3070840751</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3097257166</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-a4904f5a9f6c2a836b4901b99ef99d2391683a0d1bed7a80c7a125352f2750a3</originalsourceid><addsrcrecordid>eNp9kMtKAzEUhoMoXqov4EICbtyM5jJJJksRLwVBkO7jaSapU6eTmswIfXtjWxVcuAgJJ9_5z-FD6JSSS0qIukqU0FIVhJX5CKkKvoMOaclVoZRiu_nNS1poycQBOkppTghVUrB9dMArTcqqqg7Ry3OT3rAH24eYMHjvbN90M1y7FlY4eNx0Td_Augb1fPiArsf21S1C_-oiLFfYh4hTDzOHx-MxtqENMWdAiy101sVjtOehTe5ke4_Q5O52cvNQPD7dj2-uHwvLmewLKPNGXoD20jKouJzmAp1q7bzWNeOayooDqenU1QoqYhVQJrhgnilBgI_QxSZ2GcP74FJvFk2yrm2hc2FIhhNFqpIoQTN6_gedhyF2eblMacWEolJmim0oG0NK0XmzjM0C4spQYr70m41-k_WbtX7Dc9PZNnqYLlz90_LtOwN8A6T81c1c_J39T-wnx02PiA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3097257166</pqid></control><display><type>article</type><title>Risk factors affecting delay of initiating adjuvant chemotherapy for stage III colorectal cancer</title><source>SpringerLink Journals - AutoHoldings</source><creator>Maeda, Shingo ; Ouchi, Akira ; Komori, Koji ; Kinoshita, Takashi ; Sato, Yusuke ; Muro, Kei ; Taniguchi, Hiroya ; Masuishi, Toshiki ; Ito, Seiji ; Abe, Tetsuya ; Shimizu, Yasuhiro</creator><creatorcontrib>Maeda, Shingo ; Ouchi, Akira ; Komori, Koji ; Kinoshita, Takashi ; Sato, Yusuke ; Muro, Kei ; Taniguchi, Hiroya ; Masuishi, Toshiki ; Ito, Seiji ; Abe, Tetsuya ; Shimizu, Yasuhiro</creatorcontrib><description>Purpose
Delay in initiating adjuvant chemotherapy (AC) after curative resection of colorectal cancer (CRC) has been reported to lead to poor prognosis, but few studies have looked at associated factors. This study aimed to identify risk factors for delay in initiating AC.
Methods
Data from 200 consecutive patients who underwent curative resection and AC for stage III CRC between 2013 and 2018 were retrospectively collected and analyzed.
Results
AC was initiated more than 8 weeks after surgery in 12.5% of patients (the delay group). Compared to those with no delay (the non-delay group), patients in the delay group had significantly higher rates of synchronous double cancers (2.3% vs. 16.0%,
p
= 0.001), preoperative bowel obstruction (10.3% vs. 32.0%,
p
= 0.003), laparotomy (56.0% vs. 80.0%,
p
= 0.02), concomitant resection (2.9% vs. 24.0%,
p
< 0.001), and postoperative complications (32.0% vs. 56.0%,
p
= 0.02), and a significantly longer length of hospital stay (median 12 vs. 30 days,
p
< 0.001). In multivariate analysis, synchronous double cancers (odds ratio 10.2,
p
= 0.008), preoperative bowel obstruction (odds ratio 4.6,
p
= 0.01), concomitant resection (odds ratio 5.2,
p
= 0.03), and postoperative complications of Clavien–Dindo grade ≥ IIIa (odds ratio 4.0,
p
= 0.03) were identified as independent risk factors for delay in initiating AC.
Conclusion
Careful preoperative treatment planning for CRC patients with synchronous double cancers, preoperative bowel obstruction, and concomitant resection, and management for postoperative complication are necessary to avoid delay in initiating AC.</description><identifier>ISSN: 1341-9625</identifier><identifier>ISSN: 1437-7772</identifier><identifier>EISSN: 1437-7772</identifier><identifier>DOI: 10.1007/s10147-024-02567-3</identifier><identifier>PMID: 38904888</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Cancer Research ; Chemotherapy ; Colorectal cancer ; Colorectal carcinoma ; Complications ; Intestinal obstruction ; Intestine ; Medicine ; Medicine & Public Health ; Multivariate analysis ; Oncology ; Original Article ; Patients ; Postoperative ; Risk factors ; Surgical Oncology</subject><ispartof>International journal of clinical oncology, 2024-09, Vol.29 (9), p.1293-1301</ispartof><rights>The Author(s) under exclusive licence to Japan Society of Clinical Oncology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s) under exclusive licence to Japan Society of Clinical Oncology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-a4904f5a9f6c2a836b4901b99ef99d2391683a0d1bed7a80c7a125352f2750a3</cites><orcidid>0000-0003-0435-5370</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10147-024-02567-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10147-024-02567-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38904888$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maeda, Shingo</creatorcontrib><creatorcontrib>Ouchi, Akira</creatorcontrib><creatorcontrib>Komori, Koji</creatorcontrib><creatorcontrib>Kinoshita, Takashi</creatorcontrib><creatorcontrib>Sato, Yusuke</creatorcontrib><creatorcontrib>Muro, Kei</creatorcontrib><creatorcontrib>Taniguchi, Hiroya</creatorcontrib><creatorcontrib>Masuishi, Toshiki</creatorcontrib><creatorcontrib>Ito, Seiji</creatorcontrib><creatorcontrib>Abe, Tetsuya</creatorcontrib><creatorcontrib>Shimizu, Yasuhiro</creatorcontrib><title>Risk factors affecting delay of initiating adjuvant chemotherapy for stage III colorectal cancer</title><title>International journal of clinical oncology</title><addtitle>Int J Clin Oncol</addtitle><addtitle>Int J Clin Oncol</addtitle><description>Purpose
Delay in initiating adjuvant chemotherapy (AC) after curative resection of colorectal cancer (CRC) has been reported to lead to poor prognosis, but few studies have looked at associated factors. This study aimed to identify risk factors for delay in initiating AC.
Methods
Data from 200 consecutive patients who underwent curative resection and AC for stage III CRC between 2013 and 2018 were retrospectively collected and analyzed.
Results
AC was initiated more than 8 weeks after surgery in 12.5% of patients (the delay group). Compared to those with no delay (the non-delay group), patients in the delay group had significantly higher rates of synchronous double cancers (2.3% vs. 16.0%,
p
= 0.001), preoperative bowel obstruction (10.3% vs. 32.0%,
p
= 0.003), laparotomy (56.0% vs. 80.0%,
p
= 0.02), concomitant resection (2.9% vs. 24.0%,
p
< 0.001), and postoperative complications (32.0% vs. 56.0%,
p
= 0.02), and a significantly longer length of hospital stay (median 12 vs. 30 days,
p
< 0.001). In multivariate analysis, synchronous double cancers (odds ratio 10.2,
p
= 0.008), preoperative bowel obstruction (odds ratio 4.6,
p
= 0.01), concomitant resection (odds ratio 5.2,
p
= 0.03), and postoperative complications of Clavien–Dindo grade ≥ IIIa (odds ratio 4.0,
p
= 0.03) were identified as independent risk factors for delay in initiating AC.
Conclusion
Careful preoperative treatment planning for CRC patients with synchronous double cancers, preoperative bowel obstruction, and concomitant resection, and management for postoperative complication are necessary to avoid delay in initiating AC.</description><subject>Cancer Research</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Complications</subject><subject>Intestinal obstruction</subject><subject>Intestine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate analysis</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Postoperative</subject><subject>Risk factors</subject><subject>Surgical Oncology</subject><issn>1341-9625</issn><issn>1437-7772</issn><issn>1437-7772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUhoMoXqov4EICbtyM5jJJJksRLwVBkO7jaSapU6eTmswIfXtjWxVcuAgJJ9_5z-FD6JSSS0qIukqU0FIVhJX5CKkKvoMOaclVoZRiu_nNS1poycQBOkppTghVUrB9dMArTcqqqg7Ry3OT3rAH24eYMHjvbN90M1y7FlY4eNx0Td_Augb1fPiArsf21S1C_-oiLFfYh4hTDzOHx-MxtqENMWdAiy101sVjtOehTe5ke4_Q5O52cvNQPD7dj2-uHwvLmewLKPNGXoD20jKouJzmAp1q7bzWNeOayooDqenU1QoqYhVQJrhgnilBgI_QxSZ2GcP74FJvFk2yrm2hc2FIhhNFqpIoQTN6_gedhyF2eblMacWEolJmim0oG0NK0XmzjM0C4spQYr70m41-k_WbtX7Dc9PZNnqYLlz90_LtOwN8A6T81c1c_J39T-wnx02PiA</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Maeda, Shingo</creator><creator>Ouchi, Akira</creator><creator>Komori, Koji</creator><creator>Kinoshita, Takashi</creator><creator>Sato, Yusuke</creator><creator>Muro, Kei</creator><creator>Taniguchi, Hiroya</creator><creator>Masuishi, Toshiki</creator><creator>Ito, Seiji</creator><creator>Abe, Tetsuya</creator><creator>Shimizu, Yasuhiro</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0435-5370</orcidid></search><sort><creationdate>20240901</creationdate><title>Risk factors affecting delay of initiating adjuvant chemotherapy for stage III colorectal cancer</title><author>Maeda, Shingo ; Ouchi, Akira ; Komori, Koji ; Kinoshita, Takashi ; Sato, Yusuke ; Muro, Kei ; Taniguchi, Hiroya ; Masuishi, Toshiki ; Ito, Seiji ; Abe, Tetsuya ; Shimizu, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-a4904f5a9f6c2a836b4901b99ef99d2391683a0d1bed7a80c7a125352f2750a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cancer Research</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Complications</topic><topic>Intestinal obstruction</topic><topic>Intestine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multivariate analysis</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Patients</topic><topic>Postoperative</topic><topic>Risk factors</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maeda, Shingo</creatorcontrib><creatorcontrib>Ouchi, Akira</creatorcontrib><creatorcontrib>Komori, Koji</creatorcontrib><creatorcontrib>Kinoshita, Takashi</creatorcontrib><creatorcontrib>Sato, Yusuke</creatorcontrib><creatorcontrib>Muro, Kei</creatorcontrib><creatorcontrib>Taniguchi, Hiroya</creatorcontrib><creatorcontrib>Masuishi, Toshiki</creatorcontrib><creatorcontrib>Ito, Seiji</creatorcontrib><creatorcontrib>Abe, Tetsuya</creatorcontrib><creatorcontrib>Shimizu, Yasuhiro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maeda, Shingo</au><au>Ouchi, Akira</au><au>Komori, Koji</au><au>Kinoshita, Takashi</au><au>Sato, Yusuke</au><au>Muro, Kei</au><au>Taniguchi, Hiroya</au><au>Masuishi, Toshiki</au><au>Ito, Seiji</au><au>Abe, Tetsuya</au><au>Shimizu, Yasuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors affecting delay of initiating adjuvant chemotherapy for stage III colorectal cancer</atitle><jtitle>International journal of clinical oncology</jtitle><stitle>Int J Clin Oncol</stitle><addtitle>Int J Clin Oncol</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>29</volume><issue>9</issue><spage>1293</spage><epage>1301</epage><pages>1293-1301</pages><issn>1341-9625</issn><issn>1437-7772</issn><eissn>1437-7772</eissn><abstract>Purpose
Delay in initiating adjuvant chemotherapy (AC) after curative resection of colorectal cancer (CRC) has been reported to lead to poor prognosis, but few studies have looked at associated factors. This study aimed to identify risk factors for delay in initiating AC.
Methods
Data from 200 consecutive patients who underwent curative resection and AC for stage III CRC between 2013 and 2018 were retrospectively collected and analyzed.
Results
AC was initiated more than 8 weeks after surgery in 12.5% of patients (the delay group). Compared to those with no delay (the non-delay group), patients in the delay group had significantly higher rates of synchronous double cancers (2.3% vs. 16.0%,
p
= 0.001), preoperative bowel obstruction (10.3% vs. 32.0%,
p
= 0.003), laparotomy (56.0% vs. 80.0%,
p
= 0.02), concomitant resection (2.9% vs. 24.0%,
p
< 0.001), and postoperative complications (32.0% vs. 56.0%,
p
= 0.02), and a significantly longer length of hospital stay (median 12 vs. 30 days,
p
< 0.001). In multivariate analysis, synchronous double cancers (odds ratio 10.2,
p
= 0.008), preoperative bowel obstruction (odds ratio 4.6,
p
= 0.01), concomitant resection (odds ratio 5.2,
p
= 0.03), and postoperative complications of Clavien–Dindo grade ≥ IIIa (odds ratio 4.0,
p
= 0.03) were identified as independent risk factors for delay in initiating AC.
Conclusion
Careful preoperative treatment planning for CRC patients with synchronous double cancers, preoperative bowel obstruction, and concomitant resection, and management for postoperative complication are necessary to avoid delay in initiating AC.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>38904888</pmid><doi>10.1007/s10147-024-02567-3</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0435-5370</orcidid></addata></record> |
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| subjects | Cancer Research Chemotherapy Colorectal cancer Colorectal carcinoma Complications Intestinal obstruction Intestine Medicine Medicine & Public Health Multivariate analysis Oncology Original Article Patients Postoperative Risk factors Surgical Oncology |
| title | Risk factors affecting delay of initiating adjuvant chemotherapy for stage III colorectal cancer |
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