MKK3 depletion attenuates intestinal injury after traumatic hemorrhagic shock by restoring mitochondrial function

Background Traumatic hemorrhagic shock (THS) is a complex pathophysiological process resulting in multiple organ failure. Intestinal barrier dysfunction is one of the mechanisms implicated in multiple organ failure. The present study aimed to explore the regulatory role of mitogen-activated protein...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular biology reports 2024-12, Vol.51 (1), p.776, Article 776
Hauptverfasser:	Li, Lei, Zhang, Zhihao, Kuai, Xiangyu, Deng, Juxin, Qiu, Zhaolei, Wang, Zhenjie, Jiang, Hai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animal Biochemistry Animal models Animals Biomedical and Life Sciences Biosynthesis Blood pressure Cell Line Disease Models, Animal Heart rate Hemorrhage Hemorrhagic shock Histology Hypoxia Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestine Intestines - pathology Kinases Life Sciences Male MAP kinase MAP Kinase Kinase 3 - genetics MAP Kinase Kinase 3 - metabolism Mitochondria Mitochondria - metabolism Mitophagy MKK3 protein Morphology Multiple organ dysfunction syndrome Original Article Parkin protein PTEN-induced putative kinase Rats Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - metabolism Shock, Hemorrhagic - complications Shock, Hemorrhagic - genetics Shock, Hemorrhagic - metabolism Shock, Traumatic - complications Shock, Traumatic - genetics Shock, Traumatic - metabolism SIRT1 protein Transmission electron microscopy Vectors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!