STIM1 mediates methamphetamine-induced neuronal autophagy and apoptosis

Methamphetamine (METH) is a widely abused amphetamine-type psychoactive drug that causes serious health problems. Previous studies have demonstrated that METH can induce neuron autophagy and apoptosis in vivo and in vitro. However, the molecular mechanisms underlying METH-induced neuron autophagy an...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2024-07, Vol.103, p.134-145
Hauptverfasser:	Tian, Qin, Zhou, Jie, Xu, Zhenzhen, Wang, Bin, Liao, Jiashun, Duan, Ke, Li, Xiaoting, Huang, Enping, Xie, Wei-Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Calcium - metabolism Cells, Cultured Central Nervous System Stimulants - toxicity Corpus Striatum - drug effects Corpus Striatum - metabolism Corpus Striatum - pathology Endoplasmic Reticulum Stress - drug effects Endoplasmic Reticulum Stress - physiology Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Male Methamphetamine Methamphetamine - toxicity Mice Mice, Inbred C57BL Neurons - drug effects Neurons - metabolism Neurons - pathology Neurotoxicity ORAI1 Protein - genetics ORAI1 Protein - metabolism Proto-Oncogene Proteins c-akt - metabolism STIM1 Stromal Interaction Molecule 1 - genetics Stromal Interaction Molecule 1 - metabolism TOR Serine-Threonine Kinases - metabolism Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism
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