Construction of an in vitro simulated one compartment extravascular administration model and its comparison with classic in vitro administration model in copper chloride induced HepG2 cell death

In this study, we designed an in vitro administration device based on compartment model theory and utilized it to construct an in vitro simulated one compartment extravascular administration model of copper chloride. Within the Cmax range of 3.91–1000.00 μM, the measured concentration-time curves of...

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Veröffentlicht in:	Toxicology in vitro 2024-08, Vol.99, p.105879, Article 105879
Hauptverfasser:	Yan, Lailai, Fu, Dawei, Chen, Jie, Hao, Mingmei, Fu, Juanling, Yao, Biyun, Hao, Weidong, Zhao, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Area under the curve Cell death Cell Death - drug effects Cell Survival - drug effects Classic in vitro administration model Copper - toxicity Copper chloride Hep G2 Cells Humans In vitro simulated one compartment extravascular administration model Models, Biological Toxicity Tests - methods Toxicokinetics
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