Tubulin‐binding region alters tau–lipid interactions and changes toxicity of tau fibrils formed in the presence of phosphatidylserine lipids

Alzheimer's disease is the fastest‐growing neurodegenerative disease that affects over six million Americans. The abnormal aggregation of amyloid β peptide and Tau protein is the expected molecular cause of the loss of neurons in brains of AD patients. A growing body of evidence indicates that...

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Veröffentlicht in:Protein science 2024-07, Vol.33 (7), p.e5078-n/a
Hauptverfasser: Ali, Abid, Holman, Aidan P., Rodriguez, Axell, Matveyenka, Mikhail, Kurouski, Dmitry
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Sprache:eng
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