Effects of spironolactone on skin biophysical properties in women with acne treated with oral spironolactone
Background Spironolactone (SPL) is an effective treatment for women acne, but other effects on skin biophysical properties remain to be investigated. Objectives The aim of the current study was to explore the effects of oral SPL used to treat women acne on skin biophysical properties, including hydr...
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| Veröffentlicht in: | Journal of dermatology 2024-11, Vol.51 (11), p.1454-1460 |
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| creator | Kiratikanon, Salin Maneenut, Ananya Noppakun, Nopadon Kumtornrut, Chanat |
| description | Background
Spironolactone (SPL) is an effective treatment for women acne, but other effects on skin biophysical properties remain to be investigated.
Objectives
The aim of the current study was to explore the effects of oral SPL used to treat women acne on skin biophysical properties, including hydration, transepidermal water loss (TEWL), skin surface lipid (SSL) levels, mechanical properties, color, pH, and pore size.
Materials and Methods
Twenty‐five Thai women with acne treated with oral SPL were followed for 6 months. Skin hydration, TEWL, SSL levels, mechanical properties, color, pH, and pore size of the forehead, chest, and inner arm were evaluated at baseline and 2, 4, and 6 months after treatment with oral SPL. Facial and upper back pore size were also assessed. Clinical outcomes were changes in these skin biophysical properties at each visit compared with baseline.
Results
Skin hydration, TEWL, SSL levels, color, pH, and pore size remained stable throughout the study. Facial skin parameters at 6 months demonstrated the following changes: hydration levels, 7.60 (95% confidence interval [CI], −59.74 to 74.94); TEWL, −2.36 (95% CI, −5.77 to 1.06); L* value, 0.51 (95% CI, −0.70 to 1.72); individual typology angle, 1.65 (95% CI −2.27 to 5.57); pH, 0.01 (95% CI −0.43 to 0.46); pore size, −0.24 (95% CI, −1.21 to 0.73); and SSL levels, 7.60 (95% CI −59.74 to 74.94). Improvement of facial mechanical properties was observed. R0 (indicating skin tightness) and R1 (indicating elasticity) showed significant decreases (−0.076 [95% CI, −0.141 to −0.010] and −0.016 [95% CI, −0.033 to −0.001]). R3 and R4 (representing tiring effects) were also improved (−0.091 [95% CI, −0.158 to −0.025] and −0.022 [95% CI, −0.044 to −0.001]). Parameters in the truncal and inner arm areas remained stable, except for skin elasticity and tiring effects, which exhibited a similar trend of improvement as the facial area. The changes were notable as early as 4 months.
Conclusion
Oral SPL used for acne did not impair the skin barrier. Moreover, the skin mechanical properties were improved at 4 to 6 months. |
| doi_str_mv | 10.1111/1346-8138.17333 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3070803597</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3123165971</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2553-b810e3e417a72c13113cd9cb06751aa0a05b3d5b288a6723016fbf5f378eba1f3</originalsourceid><addsrcrecordid>eNqFkU1P4zAQhi0EWgrsmRuKxGUvAU-mjt0jgvKxQuKynC3HHasuaRzsVKj_ft0NIMFlfbCl8TOPRu8wdgr8AvK5BJzWpQJUFyARcY9NPiv7bMJRibKacnnIjlJacV7NBPAf7BCVmgk1rSasnTtHdkhFcEXqfQxdaI0dQkdF6Ir04rui8aFfbpO3pi36GHqKg6dU5J-3sKZ8-2FZGJs7hkhmoMVYCTHzX5Un7MCZNtHP9_eYPd_O_1zfl49Pdw_XV4-lrYTAslHACWkK0sjKAgKgXcxsw2spwBhuuGhwIZpKKVPLCjnUrnHCoVTUGHB4zH6N3jzu64bSoNc-WWpb01HYJI1ccsVRzGRGz7-hq7CJXZ5OI1QIdYYgU5cjZWNIKZLTffRrE7cauN4tQu9i17vY9b9F5I6zd--mWdPik_9IPgNiBN58S9v_-fTvm_ko_gtXWJL_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3123165971</pqid></control><display><type>article</type><title>Effects of spironolactone on skin biophysical properties in women with acne treated with oral spironolactone</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Kiratikanon, Salin ; Maneenut, Ananya ; Noppakun, Nopadon ; Kumtornrut, Chanat</creator><creatorcontrib>Kiratikanon, Salin ; Maneenut, Ananya ; Noppakun, Nopadon ; Kumtornrut, Chanat</creatorcontrib><description>Background
Spironolactone (SPL) is an effective treatment for women acne, but other effects on skin biophysical properties remain to be investigated.
Objectives
The aim of the current study was to explore the effects of oral SPL used to treat women acne on skin biophysical properties, including hydration, transepidermal water loss (TEWL), skin surface lipid (SSL) levels, mechanical properties, color, pH, and pore size.
Materials and Methods
Twenty‐five Thai women with acne treated with oral SPL were followed for 6 months. Skin hydration, TEWL, SSL levels, mechanical properties, color, pH, and pore size of the forehead, chest, and inner arm were evaluated at baseline and 2, 4, and 6 months after treatment with oral SPL. Facial and upper back pore size were also assessed. Clinical outcomes were changes in these skin biophysical properties at each visit compared with baseline.
Results
Skin hydration, TEWL, SSL levels, color, pH, and pore size remained stable throughout the study. Facial skin parameters at 6 months demonstrated the following changes: hydration levels, 7.60 (95% confidence interval [CI], −59.74 to 74.94); TEWL, −2.36 (95% CI, −5.77 to 1.06); L* value, 0.51 (95% CI, −0.70 to 1.72); individual typology angle, 1.65 (95% CI −2.27 to 5.57); pH, 0.01 (95% CI −0.43 to 0.46); pore size, −0.24 (95% CI, −1.21 to 0.73); and SSL levels, 7.60 (95% CI −59.74 to 74.94). Improvement of facial mechanical properties was observed. R0 (indicating skin tightness) and R1 (indicating elasticity) showed significant decreases (−0.076 [95% CI, −0.141 to −0.010] and −0.016 [95% CI, −0.033 to −0.001]). R3 and R4 (representing tiring effects) were also improved (−0.091 [95% CI, −0.158 to −0.025] and −0.022 [95% CI, −0.044 to −0.001]). Parameters in the truncal and inner arm areas remained stable, except for skin elasticity and tiring effects, which exhibited a similar trend of improvement as the facial area. The changes were notable as early as 4 months.
Conclusion
Oral SPL used for acne did not impair the skin barrier. Moreover, the skin mechanical properties were improved at 4 to 6 months.</description><identifier>ISSN: 0385-2407</identifier><identifier>ISSN: 1346-8138</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/1346-8138.17333</identifier><identifier>PMID: 38895842</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Acne ; Acne Vulgaris - drug therapy ; Administration, Oral ; Adolescent ; Adult ; Female ; Humans ; Hydration ; Hydrogen-Ion Concentration ; Mechanical properties ; Mineralocorticoid Receptor Antagonists - administration & dosage ; Mineralocorticoid Receptor Antagonists - therapeutic use ; pH effects ; Pore size ; Skin ; Skin - drug effects ; Skin - pathology ; skin barrier ; Skin Physiological Phenomena - drug effects ; spironolactone ; Spironolactone - administration & dosage ; Treatment Outcome ; Typology ; Water Loss, Insensible - drug effects ; women acne ; Young Adult</subject><ispartof>Journal of dermatology, 2024-11, Vol.51 (11), p.1454-1460</ispartof><rights>2024 Japanese Dermatological Association.</rights><rights>Copyright © 2024 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2553-b810e3e417a72c13113cd9cb06751aa0a05b3d5b288a6723016fbf5f378eba1f3</cites><orcidid>0000-0002-1597-7290 ; 0000-0002-8975-0523</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1346-8138.17333$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1346-8138.17333$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38895842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiratikanon, Salin</creatorcontrib><creatorcontrib>Maneenut, Ananya</creatorcontrib><creatorcontrib>Noppakun, Nopadon</creatorcontrib><creatorcontrib>Kumtornrut, Chanat</creatorcontrib><title>Effects of spironolactone on skin biophysical properties in women with acne treated with oral spironolactone</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>Background
Spironolactone (SPL) is an effective treatment for women acne, but other effects on skin biophysical properties remain to be investigated.
Objectives
The aim of the current study was to explore the effects of oral SPL used to treat women acne on skin biophysical properties, including hydration, transepidermal water loss (TEWL), skin surface lipid (SSL) levels, mechanical properties, color, pH, and pore size.
Materials and Methods
Twenty‐five Thai women with acne treated with oral SPL were followed for 6 months. Skin hydration, TEWL, SSL levels, mechanical properties, color, pH, and pore size of the forehead, chest, and inner arm were evaluated at baseline and 2, 4, and 6 months after treatment with oral SPL. Facial and upper back pore size were also assessed. Clinical outcomes were changes in these skin biophysical properties at each visit compared with baseline.
Results
Skin hydration, TEWL, SSL levels, color, pH, and pore size remained stable throughout the study. Facial skin parameters at 6 months demonstrated the following changes: hydration levels, 7.60 (95% confidence interval [CI], −59.74 to 74.94); TEWL, −2.36 (95% CI, −5.77 to 1.06); L* value, 0.51 (95% CI, −0.70 to 1.72); individual typology angle, 1.65 (95% CI −2.27 to 5.57); pH, 0.01 (95% CI −0.43 to 0.46); pore size, −0.24 (95% CI, −1.21 to 0.73); and SSL levels, 7.60 (95% CI −59.74 to 74.94). Improvement of facial mechanical properties was observed. R0 (indicating skin tightness) and R1 (indicating elasticity) showed significant decreases (−0.076 [95% CI, −0.141 to −0.010] and −0.016 [95% CI, −0.033 to −0.001]). R3 and R4 (representing tiring effects) were also improved (−0.091 [95% CI, −0.158 to −0.025] and −0.022 [95% CI, −0.044 to −0.001]). Parameters in the truncal and inner arm areas remained stable, except for skin elasticity and tiring effects, which exhibited a similar trend of improvement as the facial area. The changes were notable as early as 4 months.
Conclusion
Oral SPL used for acne did not impair the skin barrier. Moreover, the skin mechanical properties were improved at 4 to 6 months.</description><subject>Acne</subject><subject>Acne Vulgaris - drug therapy</subject><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Female</subject><subject>Humans</subject><subject>Hydration</subject><subject>Hydrogen-Ion Concentration</subject><subject>Mechanical properties</subject><subject>Mineralocorticoid Receptor Antagonists - administration & dosage</subject><subject>Mineralocorticoid Receptor Antagonists - therapeutic use</subject><subject>pH effects</subject><subject>Pore size</subject><subject>Skin</subject><subject>Skin - drug effects</subject><subject>Skin - pathology</subject><subject>skin barrier</subject><subject>Skin Physiological Phenomena - drug effects</subject><subject>spironolactone</subject><subject>Spironolactone - administration & dosage</subject><subject>Treatment Outcome</subject><subject>Typology</subject><subject>Water Loss, Insensible - drug effects</subject><subject>women acne</subject><subject>Young Adult</subject><issn>0385-2407</issn><issn>1346-8138</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P4zAQhi0EWgrsmRuKxGUvAU-mjt0jgvKxQuKynC3HHasuaRzsVKj_ft0NIMFlfbCl8TOPRu8wdgr8AvK5BJzWpQJUFyARcY9NPiv7bMJRibKacnnIjlJacV7NBPAf7BCVmgk1rSasnTtHdkhFcEXqfQxdaI0dQkdF6Ir04rui8aFfbpO3pi36GHqKg6dU5J-3sKZ8-2FZGJs7hkhmoMVYCTHzX5Un7MCZNtHP9_eYPd_O_1zfl49Pdw_XV4-lrYTAslHACWkK0sjKAgKgXcxsw2spwBhuuGhwIZpKKVPLCjnUrnHCoVTUGHB4zH6N3jzu64bSoNc-WWpb01HYJI1ccsVRzGRGz7-hq7CJXZ5OI1QIdYYgU5cjZWNIKZLTffRrE7cauN4tQu9i17vY9b9F5I6zd--mWdPik_9IPgNiBN58S9v_-fTvm_ko_gtXWJL_</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Kiratikanon, Salin</creator><creator>Maneenut, Ananya</creator><creator>Noppakun, Nopadon</creator><creator>Kumtornrut, Chanat</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1597-7290</orcidid><orcidid>https://orcid.org/0000-0002-8975-0523</orcidid></search><sort><creationdate>202411</creationdate><title>Effects of spironolactone on skin biophysical properties in women with acne treated with oral spironolactone</title><author>Kiratikanon, Salin ; Maneenut, Ananya ; Noppakun, Nopadon ; Kumtornrut, Chanat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2553-b810e3e417a72c13113cd9cb06751aa0a05b3d5b288a6723016fbf5f378eba1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acne</topic><topic>Acne Vulgaris - drug therapy</topic><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Female</topic><topic>Humans</topic><topic>Hydration</topic><topic>Hydrogen-Ion Concentration</topic><topic>Mechanical properties</topic><topic>Mineralocorticoid Receptor Antagonists - administration & dosage</topic><topic>Mineralocorticoid Receptor Antagonists - therapeutic use</topic><topic>pH effects</topic><topic>Pore size</topic><topic>Skin</topic><topic>Skin - drug effects</topic><topic>Skin - pathology</topic><topic>skin barrier</topic><topic>Skin Physiological Phenomena - drug effects</topic><topic>spironolactone</topic><topic>Spironolactone - administration & dosage</topic><topic>Treatment Outcome</topic><topic>Typology</topic><topic>Water Loss, Insensible - drug effects</topic><topic>women acne</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiratikanon, Salin</creatorcontrib><creatorcontrib>Maneenut, Ananya</creatorcontrib><creatorcontrib>Noppakun, Nopadon</creatorcontrib><creatorcontrib>Kumtornrut, Chanat</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiratikanon, Salin</au><au>Maneenut, Ananya</au><au>Noppakun, Nopadon</au><au>Kumtornrut, Chanat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of spironolactone on skin biophysical properties in women with acne treated with oral spironolactone</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2024-11</date><risdate>2024</risdate><volume>51</volume><issue>11</issue><spage>1454</spage><epage>1460</epage><pages>1454-1460</pages><issn>0385-2407</issn><issn>1346-8138</issn><eissn>1346-8138</eissn><abstract>Background
Spironolactone (SPL) is an effective treatment for women acne, but other effects on skin biophysical properties remain to be investigated.
Objectives
The aim of the current study was to explore the effects of oral SPL used to treat women acne on skin biophysical properties, including hydration, transepidermal water loss (TEWL), skin surface lipid (SSL) levels, mechanical properties, color, pH, and pore size.
Materials and Methods
Twenty‐five Thai women with acne treated with oral SPL were followed for 6 months. Skin hydration, TEWL, SSL levels, mechanical properties, color, pH, and pore size of the forehead, chest, and inner arm were evaluated at baseline and 2, 4, and 6 months after treatment with oral SPL. Facial and upper back pore size were also assessed. Clinical outcomes were changes in these skin biophysical properties at each visit compared with baseline.
Results
Skin hydration, TEWL, SSL levels, color, pH, and pore size remained stable throughout the study. Facial skin parameters at 6 months demonstrated the following changes: hydration levels, 7.60 (95% confidence interval [CI], −59.74 to 74.94); TEWL, −2.36 (95% CI, −5.77 to 1.06); L* value, 0.51 (95% CI, −0.70 to 1.72); individual typology angle, 1.65 (95% CI −2.27 to 5.57); pH, 0.01 (95% CI −0.43 to 0.46); pore size, −0.24 (95% CI, −1.21 to 0.73); and SSL levels, 7.60 (95% CI −59.74 to 74.94). Improvement of facial mechanical properties was observed. R0 (indicating skin tightness) and R1 (indicating elasticity) showed significant decreases (−0.076 [95% CI, −0.141 to −0.010] and −0.016 [95% CI, −0.033 to −0.001]). R3 and R4 (representing tiring effects) were also improved (−0.091 [95% CI, −0.158 to −0.025] and −0.022 [95% CI, −0.044 to −0.001]). Parameters in the truncal and inner arm areas remained stable, except for skin elasticity and tiring effects, which exhibited a similar trend of improvement as the facial area. The changes were notable as early as 4 months.
Conclusion
Oral SPL used for acne did not impair the skin barrier. Moreover, the skin mechanical properties were improved at 4 to 6 months.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38895842</pmid><doi>10.1111/1346-8138.17333</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1597-7290</orcidid><orcidid>https://orcid.org/0000-0002-8975-0523</orcidid></addata></record> |
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| subjects | Acne Acne Vulgaris - drug therapy Administration, Oral Adolescent Adult Female Humans Hydration Hydrogen-Ion Concentration Mechanical properties Mineralocorticoid Receptor Antagonists - administration & dosage Mineralocorticoid Receptor Antagonists - therapeutic use pH effects Pore size Skin Skin - drug effects Skin - pathology skin barrier Skin Physiological Phenomena - drug effects spironolactone Spironolactone - administration & dosage Treatment Outcome Typology Water Loss, Insensible - drug effects women acne Young Adult |
| title | Effects of spironolactone on skin biophysical properties in women with acne treated with oral spironolactone |
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