Racial disparities in the incidence and survival outcomes in diffuse large B‐cell lymphoma in adolescents and young adults
Diffuse large B‐cell Lymphoma (DLBCL) is an aggressive subtype of non‐Hodgkin lymphoma (NHL). The disease generally occurs in older patients. Although at a lower prevalence, the disease also occurs in the adolescent and young adult group (AYA). There is paucity of data in the literature on racial an...
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| Veröffentlicht in: | European journal of haematology 2024-10, Vol.113 (4), p.454-459 |
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| creator | Wasifuddin, Mustafa Ilerhunmwuwa, Nosakhare Paul Becerra, Henry Hakobyan, Narek Shrestha, Neharika Uche, Ifeanyi Nnamdi Lin, Htet Abowali, Hesham Zheng, Jin Yadav, Ruchi Pokhrel, Akriti Enayati, Ladan Hare, Mitchell Hehr, Rohan Kozii, Khrystyna Gibadullin, Bulat Avezbakiyev, Boris Wang, Jen‐Chin |
| description | Diffuse large B‐cell Lymphoma (DLBCL) is an aggressive subtype of non‐Hodgkin lymphoma (NHL). The disease generally occurs in older patients. Although at a lower prevalence, the disease also occurs in the adolescent and young adult group (AYA). There is paucity of data in the literature on racial and ethnic disparities in the incidence and survival outcomes of DLBCL in the AYA group. The objective of our study is to demonstrate the disparities in these outcomes. Utilizing SEER, we obtained data on patient demographics, incidence, and survival from 2000 to 2020. We observed statistically significant reduced incidence of DLBCL in all racial groups, except the non‐Hispanic Asian and Pacific Islander group (NHAPI). The non‐Hispanic Black group (NHB) had one of the lowest survival despite showing the largest decrease in incidence in DLBCL. The differences in the survival could be secondary to socioeconomic factors, however other reasons need to be explored. The increased incidence among the NHAPI group mirrors that of large population‐based studies in East Asian countries, however, underlying reasons have not been elucidated. |
| doi_str_mv | 10.1111/ejh.14255 |
| format | Article |
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The disease generally occurs in older patients. Although at a lower prevalence, the disease also occurs in the adolescent and young adult group (AYA). There is paucity of data in the literature on racial and ethnic disparities in the incidence and survival outcomes of DLBCL in the AYA group. The objective of our study is to demonstrate the disparities in these outcomes. Utilizing SEER, we obtained data on patient demographics, incidence, and survival from 2000 to 2020. We observed statistically significant reduced incidence of DLBCL in all racial groups, except the non‐Hispanic Asian and Pacific Islander group (NHAPI). The non‐Hispanic Black group (NHB) had one of the lowest survival despite showing the largest decrease in incidence in DLBCL. The differences in the survival could be secondary to socioeconomic factors, however other reasons need to be explored. The increased incidence among the NHAPI group mirrors that of large population‐based studies in East Asian countries, however, underlying reasons have not been elucidated.</description><identifier>ISSN: 0902-4441</identifier><identifier>ISSN: 1600-0609</identifier><identifier>EISSN: 1600-0609</identifier><identifier>DOI: 10.1111/ejh.14255</identifier><identifier>PMID: 38890006</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adult ; cancer incidence ; cancer survival ; DLBCL ; Ethnicity ; Female ; Health Status Disparities ; Humans ; Incidence ; Lymphoma ; Lymphoma, Large B-Cell, Diffuse - epidemiology ; Lymphoma, Large B-Cell, Diffuse - ethnology ; Lymphoma, Large B-Cell, Diffuse - mortality ; Lymphoma, Large B-Cell, Diffuse - therapy ; Male ; NHL ; Non-Hodgkin's lymphoma ; overall survival ; Population studies ; racial disparities ; Racial Groups ; SEER Program ; Socioeconomic factors ; Statistical analysis ; United States - epidemiology ; Young Adult ; Young adults</subject><ispartof>European journal of haematology, 2024-10, Vol.113 (4), p.454-459</ispartof><rights>2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2435-1ccff6dd5626b52507cc7f045ffa2e9abdc16b738fff62b26ea66ffdd1c19bc83</cites><orcidid>0000-0002-9292-8484 ; 0000-0002-6512-2506 ; 0000-0002-9623-6645</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fejh.14255$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fejh.14255$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38890006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wasifuddin, Mustafa</creatorcontrib><creatorcontrib>Ilerhunmwuwa, Nosakhare Paul</creatorcontrib><creatorcontrib>Becerra, Henry</creatorcontrib><creatorcontrib>Hakobyan, Narek</creatorcontrib><creatorcontrib>Shrestha, Neharika</creatorcontrib><creatorcontrib>Uche, Ifeanyi Nnamdi</creatorcontrib><creatorcontrib>Lin, Htet</creatorcontrib><creatorcontrib>Abowali, Hesham</creatorcontrib><creatorcontrib>Zheng, Jin</creatorcontrib><creatorcontrib>Yadav, Ruchi</creatorcontrib><creatorcontrib>Pokhrel, Akriti</creatorcontrib><creatorcontrib>Enayati, Ladan</creatorcontrib><creatorcontrib>Hare, Mitchell</creatorcontrib><creatorcontrib>Hehr, Rohan</creatorcontrib><creatorcontrib>Kozii, Khrystyna</creatorcontrib><creatorcontrib>Gibadullin, Bulat</creatorcontrib><creatorcontrib>Avezbakiyev, Boris</creatorcontrib><creatorcontrib>Wang, Jen‐Chin</creatorcontrib><title>Racial disparities in the incidence and survival outcomes in diffuse large B‐cell lymphoma in adolescents and young adults</title><title>European journal of haematology</title><addtitle>Eur J Haematol</addtitle><description>Diffuse large B‐cell Lymphoma (DLBCL) is an aggressive subtype of non‐Hodgkin lymphoma (NHL). The disease generally occurs in older patients. Although at a lower prevalence, the disease also occurs in the adolescent and young adult group (AYA). There is paucity of data in the literature on racial and ethnic disparities in the incidence and survival outcomes of DLBCL in the AYA group. The objective of our study is to demonstrate the disparities in these outcomes. Utilizing SEER, we obtained data on patient demographics, incidence, and survival from 2000 to 2020. We observed statistically significant reduced incidence of DLBCL in all racial groups, except the non‐Hispanic Asian and Pacific Islander group (NHAPI). The non‐Hispanic Black group (NHB) had one of the lowest survival despite showing the largest decrease in incidence in DLBCL. The differences in the survival could be secondary to socioeconomic factors, however other reasons need to be explored. The increased incidence among the NHAPI group mirrors that of large population‐based studies in East Asian countries, however, underlying reasons have not been elucidated.</description><subject>Adolescent</subject><subject>Adult</subject><subject>cancer incidence</subject><subject>cancer survival</subject><subject>DLBCL</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Health Status Disparities</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lymphoma</subject><subject>Lymphoma, Large B-Cell, Diffuse - epidemiology</subject><subject>Lymphoma, Large B-Cell, Diffuse - ethnology</subject><subject>Lymphoma, Large B-Cell, Diffuse - mortality</subject><subject>Lymphoma, Large B-Cell, Diffuse - therapy</subject><subject>Male</subject><subject>NHL</subject><subject>Non-Hodgkin's lymphoma</subject><subject>overall survival</subject><subject>Population studies</subject><subject>racial disparities</subject><subject>Racial Groups</subject><subject>SEER Program</subject><subject>Socioeconomic factors</subject><subject>Statistical analysis</subject><subject>United States - epidemiology</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>0902-4441</issn><issn>1600-0609</issn><issn>1600-0609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10cFqFTEUBuAgir1WF75AGXCji2mTzCQzWdrSWqUgiK5DJjnpzSUzuSaTKxdc-Ah9Rp_E3E7tQjCbQw4fPwd-hF4TfErKO4PN-pS0lLEnaEU4xjXmWDxFKywwrdu2JUfoRUobjDEVpHuOjpq-F-XHV-jnF6Wd8pVxaauimx2kyk3VvIYytDMwaajUZKqU487tigx51mFcmHHW5gSVV_EWqvPfv-40eF_5_bhdh1EdiDLBQ9Iwzek-Zx_ydFu22c_pJXpmlU_w6mEeo29Xl18vruubzx8-Xry_qTVtG1YTra3lxjBO-cAow53WncUts1ZREGowmvCha3pbGB0oB8W5tcYQTcSg--YYvV1ytzF8z5BmObp0uFRNEHKSDe5wJzomRKFv_qGbkONUrpMNIW3L-gaTot4tSseQUgQrt9GNKu4lwfJQiSyVyPtKij15SMzDCOZR_u2ggLMF_HAe9v9PkpefrpfIP-9mmFU</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Wasifuddin, Mustafa</creator><creator>Ilerhunmwuwa, Nosakhare Paul</creator><creator>Becerra, Henry</creator><creator>Hakobyan, Narek</creator><creator>Shrestha, Neharika</creator><creator>Uche, Ifeanyi Nnamdi</creator><creator>Lin, Htet</creator><creator>Abowali, Hesham</creator><creator>Zheng, Jin</creator><creator>Yadav, Ruchi</creator><creator>Pokhrel, Akriti</creator><creator>Enayati, Ladan</creator><creator>Hare, Mitchell</creator><creator>Hehr, Rohan</creator><creator>Kozii, Khrystyna</creator><creator>Gibadullin, Bulat</creator><creator>Avezbakiyev, Boris</creator><creator>Wang, Jen‐Chin</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9292-8484</orcidid><orcidid>https://orcid.org/0000-0002-6512-2506</orcidid><orcidid>https://orcid.org/0000-0002-9623-6645</orcidid></search><sort><creationdate>202410</creationdate><title>Racial disparities in the incidence and survival outcomes in diffuse large B‐cell lymphoma in adolescents and young adults</title><author>Wasifuddin, Mustafa ; 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The disease generally occurs in older patients. Although at a lower prevalence, the disease also occurs in the adolescent and young adult group (AYA). There is paucity of data in the literature on racial and ethnic disparities in the incidence and survival outcomes of DLBCL in the AYA group. The objective of our study is to demonstrate the disparities in these outcomes. Utilizing SEER, we obtained data on patient demographics, incidence, and survival from 2000 to 2020. We observed statistically significant reduced incidence of DLBCL in all racial groups, except the non‐Hispanic Asian and Pacific Islander group (NHAPI). The non‐Hispanic Black group (NHB) had one of the lowest survival despite showing the largest decrease in incidence in DLBCL. The differences in the survival could be secondary to socioeconomic factors, however other reasons need to be explored. The increased incidence among the NHAPI group mirrors that of large population‐based studies in East Asian countries, however, underlying reasons have not been elucidated.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38890006</pmid><doi>10.1111/ejh.14255</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9292-8484</orcidid><orcidid>https://orcid.org/0000-0002-6512-2506</orcidid><orcidid>https://orcid.org/0000-0002-9623-6645</orcidid></addata></record> |
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| subjects | Adolescent Adult cancer incidence cancer survival DLBCL Ethnicity Female Health Status Disparities Humans Incidence Lymphoma Lymphoma, Large B-Cell, Diffuse - epidemiology Lymphoma, Large B-Cell, Diffuse - ethnology Lymphoma, Large B-Cell, Diffuse - mortality Lymphoma, Large B-Cell, Diffuse - therapy Male NHL Non-Hodgkin's lymphoma overall survival Population studies racial disparities Racial Groups SEER Program Socioeconomic factors Statistical analysis United States - epidemiology Young Adult Young adults |
| title | Racial disparities in the incidence and survival outcomes in diffuse large B‐cell lymphoma in adolescents and young adults |
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