Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRα and TRβ

Abstract Thyroid hormone (TH) effects are mediated through TH receptors (TRs), TRα1, TRβ1, and TRβ2. The TRs bind to the DNA and regulate expression of TH target genes (canonical signaling). In addition, they mediate activation of signaling pathways (noncanonical signaling). Whether noncanonical TR...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2024-07, Vol.165 (8)
Hauptverfasser:	Hönes, Georg Sebastian, Geist, Daniela, Wenzek, Christina, Pfluger, Paul Thomas, Müller, Timo Dirk, Aguilar-Pimentel, Juan Antonio, Amarie, Oana Veronica, Becker, Lore, Dragano, Natalia, Garrett, Lillian, Hölter, Sabine Maria, Rathkolb, Birgit, Rozman, Jan, Spielmann, Nadine, Treise, Irina, Wolf, Eckhard, Wurst, Wolfgang, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabe de Angelis, Martin, Führer, Dagmar, Moeller, Lars Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acuity Anemia Animal models Animals Binding Deficient mutant Deoxyribonucleic acid DNA Energy utilization Female Females Gene expression Hyperphagia Isoforms Male Mice Mice, Inbred C57BL Mice, Knockout Phenotype Phenotypes Phenotyping Physiological effects Physiology Retina Signal Transduction - genetics Thyroid Thyroid Hormone Receptors alpha - genetics Thyroid Hormone Receptors alpha - metabolism Thyroid Hormone Receptors beta - genetics Thyroid Hormone Receptors beta - metabolism Thyroid Hormones - metabolism Transcription activation Vascularization Visual acuity
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