Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity

The human orphan G protein-coupled receptor GPR18, activated by Δ9-tetrahydrocannabinol (THC), constitutes a promising drug target in immunology and cancer. However, studies on GPR18 are hampered by the lack of suitable tool compounds. In the present study, potent and selective GPR18 agonists were d...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-06, Vol.67 (12), p.9896-9926
Hauptverfasser:	Mahardhika, Andhika B., Załuski, Michal, Schoeder, Clara T., Boshta, Nader M., Schabikowski, Jakub, Perri, Filomena, Łażewska, Dorota, Neumann, Alexander, Kremers, Sarah, Oneto, Angelo, Ressemann, Anastasiia, Latacz, Gniewomir, Namasivayam, Vigneshwaran, Kieć-Kononowicz, Katarzyna, Müller, Christa E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dronabinol - analogs & derivatives Dronabinol - chemistry Dronabinol - pharmacology HEK293 Cells Humans Mice Neoplasms - drug therapy Neoplasms - metabolism Receptors, Cannabinoid - metabolism Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - metabolism Structure-Activity Relationship
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