Predictive validity of Lupus Patient-Reported Outcome for damage accrual in patients with systemic lupus erythematosus: the LUNA Registry
The predictive validity of disease-specific quality of life (QOL) remains unknown in patients with systemic lupus erythematosus (SLE), although disease-specific measures are equally or more responsive to changes than generic QOL. We aimed to examine the predictive validity of the Lupus patient-repor...
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| creator | Nose, Yoko Onishi, Akira Nishimura, Keisuke Yamamoto, Yuzuru Sada, Ken-Ei Ichinose, Kunihiro Yoshimi, Ryusuke Ohno, Shigeru Yanai, Ryo Kajiyama, Hiroshi Sato, Shuzo Shimojima, Yasuhiro Fujiwara, Michio Kida, Takashi Miyawaki, Yoshia Matsuo, Yusuke Tsuji, Hideaki Morinobu, Akio Saegusa, Jun |
| description | The predictive validity of disease-specific quality of life (QOL) remains unknown in patients with systemic lupus erythematosus (SLE), although disease-specific measures are equally or more responsive to changes than generic QOL. We aimed to examine the predictive validity of the Lupus patient-reported outcome (PRO) for damage accrual.
Patients with SLE and ≥2 measurements over time were included in Japanese nationwide multicentre registry (LUNA). The Lupus PRO questionnaire contains both health-related (HR) and non-HR-QOL measures. Damage accrual was evaluated using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). We examined the association between the Lupus-PRO score at baseline and longitudinal SDI scores using mixed-effects models adjusted for prognostic factors.
Among 1295 patients, those with higher HR-QOL of Lupus PRO at baseline demonstrated a significantly lower increase in SDI (-0.005/year, 95% confidence interval [CI]: -0.007 to - 0.004, p |
| doi_str_mv | 10.1093/rheumatology/keae341 |
| format | Article |
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Patients with SLE and ≥2 measurements over time were included in Japanese nationwide multicentre registry (LUNA). The Lupus PRO questionnaire contains both health-related (HR) and non-HR-QOL measures. Damage accrual was evaluated using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). We examined the association between the Lupus-PRO score at baseline and longitudinal SDI scores using mixed-effects models adjusted for prognostic factors.
Among 1295 patients, those with higher HR-QOL of Lupus PRO at baseline demonstrated a significantly lower increase in SDI (-0.005/year, 95% confidence interval [CI]: -0.007 to - 0.004, p < 0.001). According to the categorisation of HR-QOL based on tertile, a similar dose-dependent effect of HR-QOL on longitudinal SDI was identified (second vs first tertile category: -0.101/year, 95% CI: -0.172 to - 0.030; third tertile category: -0.211/year, 95% CI: -0.281 to - 0.142). Non-HR-QOL was not significantly associated with the SDI scores. Among the HR-QOL domains, cognition, procreation, and physical health were significantly associated with the total SDI scores over time. HR-QOL was associated with corticosteroid-dependent and -independent SDI scores.
A higher HR-QOL of Lupus PRO was associated with a lower increase in SDI scores. Our findings imply the importance of disease-specific HR-QOL measurements in assessing prognosis.</description><identifier>ISSN: 1462-0324</identifier><identifier>ISSN: 1462-0332</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/keae341</identifier><identifier>PMID: 38885408</identifier><language>eng</language><publisher>England</publisher><ispartof>Rheumatology (Oxford, England), 2024-06</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c186t-a3f469d33f4b6a7f8912dbd02b816dc626092ee1344564b1b88932f74a97fe4b3</cites><orcidid>0000-0002-3120-1273 ; 0000-0001-7100-1121 ; 0000-0002-8110-8261 ; 0000-0002-6981-3443 ; 0000-0002-3945-307X ; 0000-0002-5740-8352 ; 0000-0003-1020-0818 ; 0000-0002-2521-246X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38885408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nose, Yoko</creatorcontrib><creatorcontrib>Onishi, Akira</creatorcontrib><creatorcontrib>Nishimura, Keisuke</creatorcontrib><creatorcontrib>Yamamoto, Yuzuru</creatorcontrib><creatorcontrib>Sada, Ken-Ei</creatorcontrib><creatorcontrib>Ichinose, Kunihiro</creatorcontrib><creatorcontrib>Yoshimi, Ryusuke</creatorcontrib><creatorcontrib>Ohno, Shigeru</creatorcontrib><creatorcontrib>Yanai, Ryo</creatorcontrib><creatorcontrib>Kajiyama, Hiroshi</creatorcontrib><creatorcontrib>Sato, Shuzo</creatorcontrib><creatorcontrib>Shimojima, Yasuhiro</creatorcontrib><creatorcontrib>Fujiwara, Michio</creatorcontrib><creatorcontrib>Kida, Takashi</creatorcontrib><creatorcontrib>Miyawaki, Yoshia</creatorcontrib><creatorcontrib>Matsuo, Yusuke</creatorcontrib><creatorcontrib>Tsuji, Hideaki</creatorcontrib><creatorcontrib>Morinobu, Akio</creatorcontrib><creatorcontrib>Saegusa, Jun</creatorcontrib><title>Predictive validity of Lupus Patient-Reported Outcome for damage accrual in patients with systemic lupus erythematosus: the LUNA Registry</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>The predictive validity of disease-specific quality of life (QOL) remains unknown in patients with systemic lupus erythematosus (SLE), although disease-specific measures are equally or more responsive to changes than generic QOL. We aimed to examine the predictive validity of the Lupus patient-reported outcome (PRO) for damage accrual.
Patients with SLE and ≥2 measurements over time were included in Japanese nationwide multicentre registry (LUNA). The Lupus PRO questionnaire contains both health-related (HR) and non-HR-QOL measures. Damage accrual was evaluated using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). We examined the association between the Lupus-PRO score at baseline and longitudinal SDI scores using mixed-effects models adjusted for prognostic factors.
Among 1295 patients, those with higher HR-QOL of Lupus PRO at baseline demonstrated a significantly lower increase in SDI (-0.005/year, 95% confidence interval [CI]: -0.007 to - 0.004, p < 0.001). According to the categorisation of HR-QOL based on tertile, a similar dose-dependent effect of HR-QOL on longitudinal SDI was identified (second vs first tertile category: -0.101/year, 95% CI: -0.172 to - 0.030; third tertile category: -0.211/year, 95% CI: -0.281 to - 0.142). Non-HR-QOL was not significantly associated with the SDI scores. Among the HR-QOL domains, cognition, procreation, and physical health were significantly associated with the total SDI scores over time. HR-QOL was associated with corticosteroid-dependent and -independent SDI scores.
A higher HR-QOL of Lupus PRO was associated with a lower increase in SDI scores. 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We aimed to examine the predictive validity of the Lupus patient-reported outcome (PRO) for damage accrual.
Patients with SLE and ≥2 measurements over time were included in Japanese nationwide multicentre registry (LUNA). The Lupus PRO questionnaire contains both health-related (HR) and non-HR-QOL measures. Damage accrual was evaluated using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). We examined the association between the Lupus-PRO score at baseline and longitudinal SDI scores using mixed-effects models adjusted for prognostic factors.
Among 1295 patients, those with higher HR-QOL of Lupus PRO at baseline demonstrated a significantly lower increase in SDI (-0.005/year, 95% confidence interval [CI]: -0.007 to - 0.004, p < 0.001). According to the categorisation of HR-QOL based on tertile, a similar dose-dependent effect of HR-QOL on longitudinal SDI was identified (second vs first tertile category: -0.101/year, 95% CI: -0.172 to - 0.030; third tertile category: -0.211/year, 95% CI: -0.281 to - 0.142). Non-HR-QOL was not significantly associated with the SDI scores. Among the HR-QOL domains, cognition, procreation, and physical health were significantly associated with the total SDI scores over time. HR-QOL was associated with corticosteroid-dependent and -independent SDI scores.
A higher HR-QOL of Lupus PRO was associated with a lower increase in SDI scores. Our findings imply the importance of disease-specific HR-QOL measurements in assessing prognosis.</abstract><cop>England</cop><pmid>38885408</pmid><doi>10.1093/rheumatology/keae341</doi><orcidid>https://orcid.org/0000-0002-3120-1273</orcidid><orcidid>https://orcid.org/0000-0001-7100-1121</orcidid><orcidid>https://orcid.org/0000-0002-8110-8261</orcidid><orcidid>https://orcid.org/0000-0002-6981-3443</orcidid><orcidid>https://orcid.org/0000-0002-3945-307X</orcidid><orcidid>https://orcid.org/0000-0002-5740-8352</orcidid><orcidid>https://orcid.org/0000-0003-1020-0818</orcidid><orcidid>https://orcid.org/0000-0002-2521-246X</orcidid></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current) |
| title | Predictive validity of Lupus Patient-Reported Outcome for damage accrual in patients with systemic lupus erythematosus: the LUNA Registry |
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