Triazole-Bridged Peptides with Enhanced Antimicrobial Activity and Potency against Pathogenic Bacteria

There are still no linear antimicrobial peptides (AMPs) available as a treatment option against bacterial infections. This is caused by several drawbacks that come with AMPs such as limited proteolytic stability and low selectivity against human cells. In this work, we screened a small library of ra...

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Veröffentlicht in:	ACS infectious diseases 2024-08, Vol.10 (8), p.2717-2727
Hauptverfasser:	Grabeck, Joshua, Mayer, Jacob, Miltz, Axel, Casoria, Michele, Quagliata, Michael, Meinberger, Denise, Klatt, Andreas R., Wielert, Isabelle, Maier, Berenike, Papini, Anna Maria, Neundorf, Ines
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antimicrobial Peptides - chemical synthesis Antimicrobial Peptides - chemistry Antimicrobial Peptides - pharmacology Bacteria - drug effects Fibroblasts - drug effects Humans Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Neisseria gonorrhoeae - drug effects Triazoles - chemistry Triazoles - pharmacology
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