Prognostic implications of mucosal and deep margin distances according to T‐status in oral tongue squamous cell carcinoma: A single‐center retrospective study
Objective To elucidate the prognostic implications of mucosal and deep margin distances in oral tongue squamous cell carcinoma (OTSCC), and to assess a different margin cut‐off value in T1‐T2 versus T3‐T4 tumors. Methods This single‐center retrospective study included 223 patients who received surge...
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| Veröffentlicht in: | Head & neck 2024-12, Vol.46 (12), p.2926-2934 |
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| creator | Poissonnet, Valentine Segier, Bertille Lopez, Raphaël Siegfried, Aurore Dupret‐Bories, Agnès Sarini, Jérôme Poulet, Vinciane Delanoë, Franck Vergez, Sébastien Chabrillac, Emilien |
| description | Objective
To elucidate the prognostic implications of mucosal and deep margin distances in oral tongue squamous cell carcinoma (OTSCC), and to assess a different margin cut‐off value in T1‐T2 versus T3‐T4 tumors.
Methods
This single‐center retrospective study included 223 patients who received surgery for a primary OTSCC between January 2017 and December 2021.
Results
Multivariable analysis showed that deep margin distance ≥3 mm in T1‐T2 tumors and ≥5 mm in T3‐T4 tumors was significantly associated with better RFS and OS. Mucosal and deep margin distances were globally clinically useful for 2‐year RFS prediction of T1‐T2 tumors, for which deep margins seemed to have more clinical utility than mucosal margins. The influence of margin distances on 2‐year RFS seemed greater for T1‐T2 tumors than T3‐T4 tumors.
Conclusion
Mucosal and deep margin distances were associated with OS and RFS in OTSCC. Shorter deep margin distances may be aimed for in T1‐T2 versus T3‐T4 tumors. |
| doi_str_mv | 10.1002/hed.27844 |
| format | Article |
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To elucidate the prognostic implications of mucosal and deep margin distances in oral tongue squamous cell carcinoma (OTSCC), and to assess a different margin cut‐off value in T1‐T2 versus T3‐T4 tumors.
Methods
This single‐center retrospective study included 223 patients who received surgery for a primary OTSCC between January 2017 and December 2021.
Results
Multivariable analysis showed that deep margin distance ≥3 mm in T1‐T2 tumors and ≥5 mm in T3‐T4 tumors was significantly associated with better RFS and OS. Mucosal and deep margin distances were globally clinically useful for 2‐year RFS prediction of T1‐T2 tumors, for which deep margins seemed to have more clinical utility than mucosal margins. The influence of margin distances on 2‐year RFS seemed greater for T1‐T2 tumors than T3‐T4 tumors.
Conclusion
Mucosal and deep margin distances were associated with OS and RFS in OTSCC. Shorter deep margin distances may be aimed for in T1‐T2 versus T3‐T4 tumors.</description><identifier>ISSN: 1043-3074</identifier><identifier>ISSN: 1097-0347</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.27844</identifier><identifier>PMID: 38884458</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>glossectomy ; margin ; Mucosa ; Oral carcinoma ; recurrence ; Squamous cell carcinoma ; Tongue ; tongue cancer ; Tumors</subject><ispartof>Head & neck, 2024-12, Vol.46 (12), p.2926-2934</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2434-e20cb101672406b8a38617c486efca4b91a42befd58a12363630396de92f0c103</cites><orcidid>0000-0002-1001-9827 ; 0000-0001-6676-0916</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.27844$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.27844$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38884458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poissonnet, Valentine</creatorcontrib><creatorcontrib>Segier, Bertille</creatorcontrib><creatorcontrib>Lopez, Raphaël</creatorcontrib><creatorcontrib>Siegfried, Aurore</creatorcontrib><creatorcontrib>Dupret‐Bories, Agnès</creatorcontrib><creatorcontrib>Sarini, Jérôme</creatorcontrib><creatorcontrib>Poulet, Vinciane</creatorcontrib><creatorcontrib>Delanoë, Franck</creatorcontrib><creatorcontrib>Vergez, Sébastien</creatorcontrib><creatorcontrib>Chabrillac, Emilien</creatorcontrib><title>Prognostic implications of mucosal and deep margin distances according to T‐status in oral tongue squamous cell carcinoma: A single‐center retrospective study</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Objective
To elucidate the prognostic implications of mucosal and deep margin distances in oral tongue squamous cell carcinoma (OTSCC), and to assess a different margin cut‐off value in T1‐T2 versus T3‐T4 tumors.
Methods
This single‐center retrospective study included 223 patients who received surgery for a primary OTSCC between January 2017 and December 2021.
Results
Multivariable analysis showed that deep margin distance ≥3 mm in T1‐T2 tumors and ≥5 mm in T3‐T4 tumors was significantly associated with better RFS and OS. Mucosal and deep margin distances were globally clinically useful for 2‐year RFS prediction of T1‐T2 tumors, for which deep margins seemed to have more clinical utility than mucosal margins. The influence of margin distances on 2‐year RFS seemed greater for T1‐T2 tumors than T3‐T4 tumors.
Conclusion
Mucosal and deep margin distances were associated with OS and RFS in OTSCC. Shorter deep margin distances may be aimed for in T1‐T2 versus T3‐T4 tumors.</description><subject>glossectomy</subject><subject>margin</subject><subject>Mucosa</subject><subject>Oral carcinoma</subject><subject>recurrence</subject><subject>Squamous cell carcinoma</subject><subject>Tongue</subject><subject>tongue cancer</subject><subject>Tumors</subject><issn>1043-3074</issn><issn>1097-0347</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kc9OFTEYxSdGIogufAHTxI0uBvrvdjruCKCYkOgC102n8821ZKYd2g7m7ngEnoFH80n8rhc2JqSLNl9_5-S0p6reMXrEKOXHv6A_4o2W8kV1wGjb1FTI5uX2LEUtaCP3q9c5X1NKhZL8VbUvtEZ6pQ-qhx8prkPMxTvip3n0zhYfQyZxINPiYrYjsaEnPcBMJpvWPpDe52KDg0ysczH1PqxJieTqz909XpQlE4RiQmWJYb0AyTeLnSLOHYwjcTY5H-JkP5MTklE8AiodhAKJJCgp5hlc8bcoLEu_eVPtDXbM8PZxP6x-fjm_Or2oL79__XZ6clk7LoWsgVPXMcpUwyVVnbZCK9Y4qRUMzsquZVbyDoZ-pS3jQuGiolU9tHygjlFxWH3c-c4p3iyQi5l83ia2ATC8EVS1rFkJxhD98B96HZcUMJ0RjOsVl4pqpD7tKIdPygkGMyePf7gxjJptcQaLM_-KQ_b9o-PSTTh9Ip-aQuB4B_z2I2yedzIX52c7y7_dRKY5</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Poissonnet, Valentine</creator><creator>Segier, Bertille</creator><creator>Lopez, Raphaël</creator><creator>Siegfried, Aurore</creator><creator>Dupret‐Bories, Agnès</creator><creator>Sarini, Jérôme</creator><creator>Poulet, Vinciane</creator><creator>Delanoë, Franck</creator><creator>Vergez, Sébastien</creator><creator>Chabrillac, Emilien</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1001-9827</orcidid><orcidid>https://orcid.org/0000-0001-6676-0916</orcidid></search><sort><creationdate>202412</creationdate><title>Prognostic implications of mucosal and deep margin distances according to T‐status in oral tongue squamous cell carcinoma: A single‐center retrospective study</title><author>Poissonnet, Valentine ; Segier, Bertille ; Lopez, Raphaël ; Siegfried, Aurore ; Dupret‐Bories, Agnès ; Sarini, Jérôme ; Poulet, Vinciane ; Delanoë, Franck ; Vergez, Sébastien ; Chabrillac, Emilien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2434-e20cb101672406b8a38617c486efca4b91a42befd58a12363630396de92f0c103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>glossectomy</topic><topic>margin</topic><topic>Mucosa</topic><topic>Oral carcinoma</topic><topic>recurrence</topic><topic>Squamous cell carcinoma</topic><topic>Tongue</topic><topic>tongue cancer</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poissonnet, Valentine</creatorcontrib><creatorcontrib>Segier, Bertille</creatorcontrib><creatorcontrib>Lopez, Raphaël</creatorcontrib><creatorcontrib>Siegfried, Aurore</creatorcontrib><creatorcontrib>Dupret‐Bories, Agnès</creatorcontrib><creatorcontrib>Sarini, Jérôme</creatorcontrib><creatorcontrib>Poulet, Vinciane</creatorcontrib><creatorcontrib>Delanoë, Franck</creatorcontrib><creatorcontrib>Vergez, Sébastien</creatorcontrib><creatorcontrib>Chabrillac, Emilien</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poissonnet, Valentine</au><au>Segier, Bertille</au><au>Lopez, Raphaël</au><au>Siegfried, Aurore</au><au>Dupret‐Bories, Agnès</au><au>Sarini, Jérôme</au><au>Poulet, Vinciane</au><au>Delanoë, Franck</au><au>Vergez, Sébastien</au><au>Chabrillac, Emilien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic implications of mucosal and deep margin distances according to T‐status in oral tongue squamous cell carcinoma: A single‐center retrospective study</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2024-12</date><risdate>2024</risdate><volume>46</volume><issue>12</issue><spage>2926</spage><epage>2934</epage><pages>2926-2934</pages><issn>1043-3074</issn><issn>1097-0347</issn><eissn>1097-0347</eissn><abstract>Objective
To elucidate the prognostic implications of mucosal and deep margin distances in oral tongue squamous cell carcinoma (OTSCC), and to assess a different margin cut‐off value in T1‐T2 versus T3‐T4 tumors.
Methods
This single‐center retrospective study included 223 patients who received surgery for a primary OTSCC between January 2017 and December 2021.
Results
Multivariable analysis showed that deep margin distance ≥3 mm in T1‐T2 tumors and ≥5 mm in T3‐T4 tumors was significantly associated with better RFS and OS. Mucosal and deep margin distances were globally clinically useful for 2‐year RFS prediction of T1‐T2 tumors, for which deep margins seemed to have more clinical utility than mucosal margins. The influence of margin distances on 2‐year RFS seemed greater for T1‐T2 tumors than T3‐T4 tumors.
Conclusion
Mucosal and deep margin distances were associated with OS and RFS in OTSCC. Shorter deep margin distances may be aimed for in T1‐T2 versus T3‐T4 tumors.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>38884458</pmid><doi>10.1002/hed.27844</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1001-9827</orcidid><orcidid>https://orcid.org/0000-0001-6676-0916</orcidid></addata></record> |
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| source | Wiley Online Library All Journals |
| subjects | glossectomy margin Mucosa Oral carcinoma recurrence Squamous cell carcinoma Tongue tongue cancer Tumors |
| title | Prognostic implications of mucosal and deep margin distances according to T‐status in oral tongue squamous cell carcinoma: A single‐center retrospective study |
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