Community-Based Cluster-Randomized Trial to Reduce Opioid Overdose Deaths
In 67 U.S. communities with a high death rate from opioid overdoses, an intervention to increase the use of evidence-based practices did not result in lower death rates.
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| Veröffentlicht in: | The New England journal of medicine 2024-09, Vol.391 (11), p.989-1001 |
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| container_title | The New England journal of medicine |
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| creator | Samet, Jeffrey H El-Bassel, Nabila Winhusen, T John Jackson, Rebecca D Oga, Emmanuel A Chandler, Redonna K Villani, Jennifer Freisthler, Bridget Adams, Joella Aldridge, Arnie Angerame, Angelo Babineau, Denise C Bagley, Sarah M Baker, Trevor J Balvanz, Peter Barbosa, Carolina Barocas, Joshua Battaglia, Tracy A Beard, Dacia D Beers, Donna Blevins, Derek Bove, Nicholas Bridden, Carly Brown, Jennifer L Bush, Heather M Bush, Joshua L Caldwell, Ryan Calver, Katherine Calvert, Deirdre Campbell, Aimee N C Carpenter, Jane Caspar, Rachel Chassler, Deborah Chaya, Joan Cheng, Debbie M Cunningham, Chinazo O Dasgupta, Anindita David, James L Davis, Alissa Dean, Tammy Drainoni, Mari-Lynn Eggleston, Barry Fanucchi, Laura C Feaster, Daniel J Fernandez, Soledad Figueroa, Wilson Freedman, Darcy A Freeman, Patricia R Freiermuth, Caroline E Friedlander, Eric Gelberg, Kitty H Gibson, Erin B Gilbert, Louisa Glasgow, LaShawn Goddard-Eckrich, Dawn A Gomori, Stephen Gruss, Dawn E Gulley, Jennifer Gutnick, Damara Hall, Megan E Harger Dykes, Nicole Hargrove, Sarah L Harlow, Kristin Harris, Aumani Harris, Daniel Helme, Donald W Holloway, JaNae Hotchkiss, Juanita Huang, Terry Huerta, Timothy R Hunt, Timothy Hyder, Ayaz Ingram, Van L Ingram, Tim Kauffman, Emily Kimball, Jennifer L Kinnard, Elizabeth N Knott, Charles Knudsen, Hannah K Konstan, Michael W Kosakowski, Sarah Larochelle, Marc R Leaver, Hannah M LeBaron, Patricia A Lefebvre, R Craig Levin, Frances R Lewis, Nikki Lewis, Nicky Lofwall, Michelle R Lounsbury, David W Luster, Jamie E Lyons, Michael S Mack, Aimee Marks, Katherine R Marquesano, Stephanie Mauk, Rachel McAlearney, Ann Scheck McConnell, Kristin McGladrey, Margaret L McMullan, Jason |
| description | In 67 U.S. communities with a high death rate from opioid overdoses, an intervention to increase the use of evidence-based practices did not result in lower death rates. |
| doi_str_mv | 10.1056/NEJMoa2401177 |
| format | Article |
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El-Bassel, Nabila ; Winhusen, T John ; Jackson, Rebecca D ; Oga, Emmanuel A ; Chandler, Redonna K ; Villani, Jennifer ; Freisthler, Bridget ; Adams, Joella ; Aldridge, Arnie ; Angerame, Angelo ; Babineau, Denise C ; Bagley, Sarah M ; Baker, Trevor J ; Balvanz, Peter ; Barbosa, Carolina ; Barocas, Joshua ; Battaglia, Tracy A ; Beard, Dacia D ; Beers, Donna ; Blevins, Derek ; Bove, Nicholas ; Bridden, Carly ; Brown, Jennifer L ; Bush, Heather M ; Bush, Joshua L ; Caldwell, Ryan ; Calver, Katherine ; Calvert, Deirdre ; Campbell, Aimee N C ; Carpenter, Jane ; Caspar, Rachel ; Chassler, Deborah ; Chaya, Joan ; Cheng, Debbie M ; Cunningham, Chinazo O ; Dasgupta, Anindita ; David, James L ; Davis, Alissa ; Dean, Tammy ; Drainoni, Mari-Lynn ; Eggleston, Barry ; Fanucchi, Laura C ; Feaster, Daniel J ; Fernandez, Soledad ; Figueroa, Wilson ; Freedman, Darcy A ; Freeman, Patricia R ; Freiermuth, Caroline E ; Friedlander, Eric ; Gelberg, Kitty H ; Gibson, Erin B ; Gilbert, Louisa ; Glasgow, LaShawn ; Goddard-Eckrich, Dawn A ; Gomori, Stephen ; Gruss, Dawn E ; Gulley, Jennifer ; Gutnick, Damara ; Hall, Megan E ; Harger Dykes, Nicole ; Hargrove, Sarah L ; Harlow, Kristin ; Harris, Aumani ; Harris, Daniel ; Helme, Donald W ; Holloway, JaNae ; Hotchkiss, Juanita ; Huang, Terry ; Huerta, Timothy R ; Hunt, Timothy ; Hyder, Ayaz ; Ingram, Van L ; Ingram, Tim ; Kauffman, Emily ; Kimball, Jennifer L ; Kinnard, Elizabeth N ; Knott, Charles ; Knudsen, Hannah K ; Konstan, Michael W ; Kosakowski, Sarah ; Larochelle, Marc R ; Leaver, Hannah M ; LeBaron, Patricia A ; Lefebvre, R Craig ; Levin, Frances R ; Lewis, Nikki ; Lewis, Nicky ; Lofwall, Michelle R ; Lounsbury, David W ; Luster, Jamie E ; Lyons, Michael S ; Mack, Aimee ; Marks, Katherine R ; Marquesano, Stephanie ; Mauk, Rachel ; McAlearney, Ann Scheck ; McConnell, Kristin ; McGladrey, Margaret L ; McMullan, Jason</creator><creatorcontrib>Samet, Jeffrey H ; El-Bassel, Nabila ; Winhusen, T John ; Jackson, Rebecca D ; Oga, Emmanuel A ; Chandler, Redonna K ; Villani, Jennifer ; Freisthler, Bridget ; Adams, Joella ; Aldridge, Arnie ; Angerame, Angelo ; Babineau, Denise C ; Bagley, Sarah M ; Baker, Trevor J ; Balvanz, Peter ; Barbosa, Carolina ; Barocas, Joshua ; Battaglia, Tracy A ; Beard, Dacia D ; Beers, Donna ; Blevins, Derek ; Bove, Nicholas ; Bridden, Carly ; Brown, Jennifer L ; Bush, Heather M ; Bush, Joshua L ; Caldwell, Ryan ; Calver, Katherine ; Calvert, Deirdre ; Campbell, Aimee N C ; Carpenter, Jane ; Caspar, Rachel ; Chassler, Deborah ; Chaya, Joan ; Cheng, Debbie M ; Cunningham, Chinazo O ; Dasgupta, Anindita ; David, James L ; Davis, Alissa ; Dean, Tammy ; Drainoni, Mari-Lynn ; Eggleston, Barry ; Fanucchi, Laura C ; Feaster, Daniel J ; Fernandez, Soledad ; Figueroa, Wilson ; Freedman, Darcy A ; Freeman, Patricia R ; Freiermuth, Caroline E ; Friedlander, Eric ; Gelberg, Kitty H ; Gibson, Erin B ; Gilbert, Louisa ; Glasgow, LaShawn ; Goddard-Eckrich, Dawn A ; Gomori, Stephen ; Gruss, Dawn E ; Gulley, Jennifer ; Gutnick, Damara ; Hall, Megan E ; Harger Dykes, Nicole ; Hargrove, Sarah L ; Harlow, Kristin ; Harris, Aumani ; Harris, Daniel ; Helme, Donald W ; Holloway, JaNae ; Hotchkiss, Juanita ; Huang, Terry ; Huerta, Timothy R ; Hunt, Timothy ; Hyder, Ayaz ; Ingram, Van L ; Ingram, Tim ; Kauffman, Emily ; Kimball, Jennifer L ; Kinnard, Elizabeth N ; Knott, Charles ; Knudsen, Hannah K ; Konstan, Michael W ; Kosakowski, Sarah ; Larochelle, Marc R ; Leaver, Hannah M ; LeBaron, Patricia A ; Lefebvre, R Craig ; Levin, Frances R ; Lewis, Nikki ; Lewis, Nicky ; Lofwall, Michelle R ; Lounsbury, David W ; Luster, Jamie E ; Lyons, Michael S ; Mack, Aimee ; Marks, Katherine R ; Marquesano, Stephanie ; Mauk, Rachel ; McAlearney, Ann Scheck ; McConnell, Kristin ; McGladrey, Margaret L ; McMullan, Jason ; The HEALing Communities Study Consortium ; HEALing Communities Study Consortium ; The HEALing Communities Study Consortium</creatorcontrib><description>In 67 U.S. communities with a high death rate from opioid overdoses, an intervention to increase the use of evidence-based practices did not result in lower death rates.</description><identifier>ISSN: 0028-4793</identifier><identifier>ISSN: 1533-4406</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa2401177</identifier><identifier>PMID: 38884347</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Addiction ; Adult ; Analgesics, Opioid - poisoning ; Analgesics, Opioid - therapeutic use ; and Education ; and Education General ; and Inclusion ; and Inclusion General ; Clinical Medicine ; Clinical Medicine General ; Communication ; Coronaviruses ; COVID-19 ; COVID-19 - mortality ; COVID-19 - prevention & control ; Diversity ; Drug abuse ; Drug addiction ; Drug overdose ; Drug Overdose - mortality ; Drug Overdose - prevention & control ; Drug use ; Emergency Medicine ; Emergency Medicine General ; Emergency services ; Equity ; Evidence-based practice ; Female ; Fentanyl ; Fentanyl - poisoning ; Health Care Delivery ; Health Policy ; Humans ; Hypothesis testing ; Intervention ; Male ; Medical Practice ; Middle Aged ; Minority & ethnic groups ; Naloxone ; Naloxone - therapeutic use ; Narcotic Antagonists - therapeutic use ; Narcotics ; Neurology ; Neurosurgery ; Neurosurgery General ; Opiate Overdose - mortality ; Opiate Overdose - prevention & control ; Opioid-Related Disorders - mortality ; Opioid-Related Disorders - prevention & control ; Opioids ; Outpatient-Based Clinical Medicine ; Overdose ; Pandemics ; Pediatrics ; Pediatrics General ; Population ; Psychiatry ; Psychiatry General ; Public Health ; Public Health General ; Standard deviation ; Stigma ; Substance abuse treatment ; Substance use disorder ; Toxicology ; Training ; United States - epidemiology</subject><ispartof>The New England journal of medicine, 2024-09, Vol.391 (11), p.989-1001</ispartof><rights>Copyright © 2024 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2024 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1527-2dda931ee13652bd8c2ce517f17d98824fa35b824f9142a320d74d44a5368a7c3</cites><orcidid>0000-0001-7822-1143 ; 0000-0003-2337-2504 ; 0000-0003-4865-6482</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3106718526?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38884347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samet, Jeffrey H</creatorcontrib><creatorcontrib>El-Bassel, Nabila</creatorcontrib><creatorcontrib>Winhusen, T John</creatorcontrib><creatorcontrib>Jackson, Rebecca D</creatorcontrib><creatorcontrib>Oga, Emmanuel A</creatorcontrib><creatorcontrib>Chandler, Redonna K</creatorcontrib><creatorcontrib>Villani, Jennifer</creatorcontrib><creatorcontrib>Freisthler, Bridget</creatorcontrib><creatorcontrib>Adams, Joella</creatorcontrib><creatorcontrib>Aldridge, Arnie</creatorcontrib><creatorcontrib>Angerame, Angelo</creatorcontrib><creatorcontrib>Babineau, Denise C</creatorcontrib><creatorcontrib>Bagley, Sarah M</creatorcontrib><creatorcontrib>Baker, Trevor J</creatorcontrib><creatorcontrib>Balvanz, Peter</creatorcontrib><creatorcontrib>Barbosa, Carolina</creatorcontrib><creatorcontrib>Barocas, Joshua</creatorcontrib><creatorcontrib>Battaglia, Tracy A</creatorcontrib><creatorcontrib>Beard, Dacia D</creatorcontrib><creatorcontrib>Beers, Donna</creatorcontrib><creatorcontrib>Blevins, Derek</creatorcontrib><creatorcontrib>Bove, Nicholas</creatorcontrib><creatorcontrib>Bridden, 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C</creatorcontrib><creatorcontrib>Feaster, Daniel J</creatorcontrib><creatorcontrib>Fernandez, Soledad</creatorcontrib><creatorcontrib>Figueroa, Wilson</creatorcontrib><creatorcontrib>Freedman, Darcy A</creatorcontrib><creatorcontrib>Freeman, Patricia R</creatorcontrib><creatorcontrib>Freiermuth, Caroline E</creatorcontrib><creatorcontrib>Friedlander, Eric</creatorcontrib><creatorcontrib>Gelberg, Kitty H</creatorcontrib><creatorcontrib>Gibson, Erin B</creatorcontrib><creatorcontrib>Gilbert, Louisa</creatorcontrib><creatorcontrib>Glasgow, LaShawn</creatorcontrib><creatorcontrib>Goddard-Eckrich, Dawn A</creatorcontrib><creatorcontrib>Gomori, Stephen</creatorcontrib><creatorcontrib>Gruss, Dawn E</creatorcontrib><creatorcontrib>Gulley, Jennifer</creatorcontrib><creatorcontrib>Gutnick, Damara</creatorcontrib><creatorcontrib>Hall, Megan E</creatorcontrib><creatorcontrib>Harger Dykes, Nicole</creatorcontrib><creatorcontrib>Hargrove, Sarah L</creatorcontrib><creatorcontrib>Harlow, 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M</creatorcontrib><creatorcontrib>LeBaron, Patricia A</creatorcontrib><creatorcontrib>Lefebvre, R Craig</creatorcontrib><creatorcontrib>Levin, Frances R</creatorcontrib><creatorcontrib>Lewis, Nikki</creatorcontrib><creatorcontrib>Lewis, Nicky</creatorcontrib><creatorcontrib>Lofwall, Michelle R</creatorcontrib><creatorcontrib>Lounsbury, David W</creatorcontrib><creatorcontrib>Luster, Jamie E</creatorcontrib><creatorcontrib>Lyons, Michael S</creatorcontrib><creatorcontrib>Mack, Aimee</creatorcontrib><creatorcontrib>Marks, Katherine R</creatorcontrib><creatorcontrib>Marquesano, Stephanie</creatorcontrib><creatorcontrib>Mauk, Rachel</creatorcontrib><creatorcontrib>McAlearney, Ann Scheck</creatorcontrib><creatorcontrib>McConnell, Kristin</creatorcontrib><creatorcontrib>McGladrey, Margaret L</creatorcontrib><creatorcontrib>McMullan, Jason</creatorcontrib><creatorcontrib>The HEALing Communities Study Consortium</creatorcontrib><creatorcontrib>HEALing Communities Study Consortium</creatorcontrib><creatorcontrib>The HEALing Communities Study Consortium</creatorcontrib><title>Community-Based Cluster-Randomized Trial to Reduce Opioid Overdose Deaths</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In 67 U.S. communities with a high death rate from opioid overdoses, an intervention to increase the use of evidence-based practices did not result in lower death rates.</description><subject>Addiction</subject><subject>Adult</subject><subject>Analgesics, Opioid - poisoning</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>and Education</subject><subject>and Education General</subject><subject>and Inclusion</subject><subject>and Inclusion General</subject><subject>Clinical Medicine</subject><subject>Clinical Medicine General</subject><subject>Communication</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - mortality</subject><subject>COVID-19 - prevention & control</subject><subject>Diversity</subject><subject>Drug abuse</subject><subject>Drug addiction</subject><subject>Drug overdose</subject><subject>Drug Overdose - mortality</subject><subject>Drug Overdose - prevention & control</subject><subject>Drug use</subject><subject>Emergency Medicine</subject><subject>Emergency Medicine General</subject><subject>Emergency services</subject><subject>Equity</subject><subject>Evidence-based practice</subject><subject>Female</subject><subject>Fentanyl</subject><subject>Fentanyl - poisoning</subject><subject>Health Care Delivery</subject><subject>Health Policy</subject><subject>Humans</subject><subject>Hypothesis testing</subject><subject>Intervention</subject><subject>Male</subject><subject>Medical Practice</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Naloxone</subject><subject>Naloxone - therapeutic use</subject><subject>Narcotic Antagonists - therapeutic use</subject><subject>Narcotics</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Neurosurgery General</subject><subject>Opiate Overdose - mortality</subject><subject>Opiate Overdose - prevention & control</subject><subject>Opioid-Related Disorders - mortality</subject><subject>Opioid-Related Disorders - prevention & control</subject><subject>Opioids</subject><subject>Outpatient-Based Clinical Medicine</subject><subject>Overdose</subject><subject>Pandemics</subject><subject>Pediatrics</subject><subject>Pediatrics General</subject><subject>Population</subject><subject>Psychiatry</subject><subject>Psychiatry General</subject><subject>Public Health</subject><subject>Public Health General</subject><subject>Standard deviation</subject><subject>Stigma</subject><subject>Substance abuse treatment</subject><subject>Substance use disorder</subject><subject>Toxicology</subject><subject>Training</subject><subject>United States - 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Cluster-Randomized Trial to Reduce Opioid Overdose Deaths</title><author>Samet, Jeffrey H ; El-Bassel, Nabila ; Winhusen, T John ; Jackson, Rebecca D ; Oga, Emmanuel A ; Chandler, Redonna K ; Villani, Jennifer ; Freisthler, Bridget ; Adams, Joella ; Aldridge, Arnie ; Angerame, Angelo ; Babineau, Denise C ; Bagley, Sarah M ; Baker, Trevor J ; Balvanz, Peter ; Barbosa, Carolina ; Barocas, Joshua ; Battaglia, Tracy A ; Beard, Dacia D ; Beers, Donna ; Blevins, Derek ; Bove, Nicholas ; Bridden, Carly ; Brown, Jennifer L ; Bush, Heather M ; Bush, Joshua L ; Caldwell, Ryan ; Calver, Katherine ; Calvert, Deirdre ; Campbell, Aimee N C ; Carpenter, Jane ; Caspar, Rachel ; Chassler, Deborah ; Chaya, Joan ; Cheng, Debbie M ; Cunningham, Chinazo O ; Dasgupta, Anindita ; David, James L ; Davis, Alissa ; Dean, Tammy ; Drainoni, Mari-Lynn ; Eggleston, Barry ; Fanucchi, Laura C ; Feaster, Daniel J ; Fernandez, Soledad ; Figueroa, Wilson ; Freedman, Darcy A ; Freeman, Patricia R ; Freiermuth, Caroline E ; Friedlander, Eric ; Gelberg, Kitty H ; Gibson, Erin B ; Gilbert, Louisa ; Glasgow, LaShawn ; Goddard-Eckrich, Dawn A ; Gomori, Stephen ; Gruss, Dawn E ; Gulley, Jennifer ; Gutnick, Damara ; Hall, Megan E ; Harger Dykes, Nicole ; Hargrove, Sarah L ; Harlow, Kristin ; Harris, Aumani ; Harris, Daniel ; Helme, Donald W ; Holloway, JaNae ; Hotchkiss, Juanita ; Huang, Terry ; Huerta, Timothy R ; Hunt, Timothy ; Hyder, Ayaz ; Ingram, Van L ; Ingram, Tim ; Kauffman, Emily ; Kimball, Jennifer L ; Kinnard, Elizabeth N ; Knott, Charles ; Knudsen, Hannah K ; Konstan, Michael W ; Kosakowski, Sarah ; Larochelle, Marc R ; Leaver, Hannah M ; LeBaron, Patricia A ; Lefebvre, R Craig ; Levin, Frances R ; Lewis, Nikki ; Lewis, Nicky ; Lofwall, Michelle R ; Lounsbury, David W ; Luster, Jamie E ; Lyons, Michael S ; Mack, Aimee ; Marks, Katherine R ; Marquesano, Stephanie ; Mauk, Rachel ; McAlearney, Ann Scheck ; McConnell, Kristin ; McGladrey, Margaret L ; McMullan, Jason</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1527-2dda931ee13652bd8c2ce517f17d98824fa35b824f9142a320d74d44a5368a7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Addiction</topic><topic>Adult</topic><topic>Analgesics, Opioid - poisoning</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>and Education</topic><topic>and Education General</topic><topic>and Inclusion</topic><topic>and Inclusion General</topic><topic>Clinical Medicine</topic><topic>Clinical Medicine General</topic><topic>Communication</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - mortality</topic><topic>COVID-19 - prevention & control</topic><topic>Diversity</topic><topic>Drug abuse</topic><topic>Drug addiction</topic><topic>Drug overdose</topic><topic>Drug Overdose - mortality</topic><topic>Drug Overdose - prevention & control</topic><topic>Drug 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Clinical Medicine</topic><topic>Overdose</topic><topic>Pandemics</topic><topic>Pediatrics</topic><topic>Pediatrics General</topic><topic>Population</topic><topic>Psychiatry</topic><topic>Psychiatry General</topic><topic>Public Health</topic><topic>Public Health General</topic><topic>Standard deviation</topic><topic>Stigma</topic><topic>Substance abuse treatment</topic><topic>Substance use disorder</topic><topic>Toxicology</topic><topic>Training</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samet, Jeffrey H</creatorcontrib><creatorcontrib>El-Bassel, Nabila</creatorcontrib><creatorcontrib>Winhusen, T John</creatorcontrib><creatorcontrib>Jackson, Rebecca D</creatorcontrib><creatorcontrib>Oga, Emmanuel A</creatorcontrib><creatorcontrib>Chandler, Redonna K</creatorcontrib><creatorcontrib>Villani, Jennifer</creatorcontrib><creatorcontrib>Freisthler, Bridget</creatorcontrib><creatorcontrib>Adams, 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| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2024-09, Vol.391 (11), p.989-1001 |
| issn | 0028-4793 1533-4406 1533-4406 |
| language | eng |
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| source | MEDLINE; ProQuest Central UK/Ireland |
| subjects | Addiction Adult Analgesics, Opioid - poisoning Analgesics, Opioid - therapeutic use and Education and Education General and Inclusion and Inclusion General Clinical Medicine Clinical Medicine General Communication Coronaviruses COVID-19 COVID-19 - mortality COVID-19 - prevention & control Diversity Drug abuse Drug addiction Drug overdose Drug Overdose - mortality Drug Overdose - prevention & control Drug use Emergency Medicine Emergency Medicine General Emergency services Equity Evidence-based practice Female Fentanyl Fentanyl - poisoning Health Care Delivery Health Policy Humans Hypothesis testing Intervention Male Medical Practice Middle Aged Minority & ethnic groups Naloxone Naloxone - therapeutic use Narcotic Antagonists - therapeutic use Narcotics Neurology Neurosurgery Neurosurgery General Opiate Overdose - mortality Opiate Overdose - prevention & control Opioid-Related Disorders - mortality Opioid-Related Disorders - prevention & control Opioids Outpatient-Based Clinical Medicine Overdose Pandemics Pediatrics Pediatrics General Population Psychiatry Psychiatry General Public Health Public Health General Standard deviation Stigma Substance abuse treatment Substance use disorder Toxicology Training United States - epidemiology |
| title | Community-Based Cluster-Randomized Trial to Reduce Opioid Overdose Deaths |
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