Seven-membered N-heterocycles as approved drugs and promising leads in medicinal chemistry as well as the metal-free domino access to their scaffolds

Azepanes or azepines are structural motifs of many drugs, drug candidates and evaluated lead compounds. Even though compounds having N-heterocyclic 7-membered rings are often found in nature (e.g. alkaloids), the natural compounds of this group are rather rare as approved therapeutics. Thus, recentl...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-09, Vol.275, p.116556, Article 116556
Hauptverfasser:	Leśniewska, Aleksandra, Przybylski, Piotr
Format:	Artikel
Sprache:	eng
Schlagworte:	Azepanes Azepines Biological activity Cascade Covalent and non-covalent inhibitors Drug-target interactions SAR Stereoisomeric drugs and drug candidates
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