KCNE4-dependent modulation of Kv1.3 pharmacology

[Display omitted] The voltage-dependent potassium channel Kv1.3 is a promising therapeutic target for the treatment of autoimmune and chronic inflammatory disorders. Kv1.3 blockers are effective in treating multiple sclerosis (fampridine) and psoriasis (dalazatide). However, most Kv1.3 pharmacologic...

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Veröffentlicht in:	Biochemical pharmacology 2024-08, Vol.226, p.116368, Article 116368
Hauptverfasser:	Sastre, Daniel, Colomer-Molera, Magalí, de Benito-Bueno, Angela, Valenzuela, Carmen, Fernández-Ballester, Gregorio, Felipe, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune diseases CHO Cells Cricetulus Ficusin HEK293 Cells Humans Kv1.3 Potassium Channel - antagonists & inhibitors Kv1.3 Potassium Channel - genetics Kv1.3 Potassium Channel - metabolism Leukocytes Oligomeric complex Potassium Channel Blockers - pharmacology Potassium channels Potassium Channels, Voltage-Gated - antagonists & inhibitors Potassium Channels, Voltage-Gated - metabolism Regulatory subunits Scorpion Venoms
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