$Osthole accelerates osteoporotic fracture healing by inducing the osteogenesis–angiogenesis coupling of BMSCs via the Wnt/β‐catenin pathway$

Osthole accelerates osteoporotic fracture healing by inducing the osteogenesis–angiogenesis coupling of BMSCs via the Wnt/β‐catenin pathway

Osthole, a natural coumarin derivative, has been shown to have multiple pharmacological activities. However, its effect on osteoporotic fracture has not yet been examined. This research was designed to explore the unknown role and potential mechanism of osthole on osteoporotic fracture healing. We f...

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Veröffentlicht in:	Phytotherapy research 2024-08, Vol.38 (8), p.4022-4035
Hauptverfasser:	Zheng, Sheng, Hu, Guanyu, Zheng, Jia, Li, Yikai, Li, Junhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis animal models Animals beta Catenin - metabolism bone formation bone fractures Bone growth Bone healing Bone marrow bone marrow mesenchymal stem cells Catenin Coumarin Coumarins - pharmacology Disease Models, Animal drugs Endothelial cells Female Fluorescence Fracture Healing - drug effects Fractures Healing Histology Human performance Human Umbilical Vein Endothelial Cells - drug effects Humans Labelling Mesenchymal stem cells Mesenchymal Stem Cells - drug effects Molecular modelling Neovascularization, Physiologic - drug effects Oophorectomy Osteogenesis Osteogenesis - drug effects osteogenesis–angiogenesis coupling Osteoporosis Osteoporosis - drug therapy osteoporotic fracture Osteoporotic Fractures - drug therapy osthole Ovariectomy phytotherapy placebos Radiography Rats Rats, Sprague-Dawley Stem cells Tibia Umbilical vein Wnt protein Wnt Signaling Pathway - drug effects Wnt/β‐catenin
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